Sedative and brain-invigorating oral liquid with improved clarity and stability and preparation thereof

A technology of stability and clarity, applied in the field of medicine, can solve the problems of product return, lack of clarity stability of Anshen Bunao Liquid, and precipitation of Anshen Bunao Liquid.

Inactive Publication Date: 2008-12-17
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the production according to the existing legal process, Anshen Tonic Liquid will produce precipitation during the placement process, which will affect the appearance and quality of the product, and cause the product to be returned. This has always been a technical problem that the manufacturer urgently needs to solve.
In recent years, Jilin Aodong Pharmaceutical Co., Ltd. has added ceramic membrane filtration technology to the production process of this product, which has improved the clarity of Anshen Tonic Liquid to a certain extent, but this technology has not fundamentally solved the problem of Anshen Tonic. Cerebral fluid clarity stability issues

Method used

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  • Sedative and brain-invigorating oral liquid with improved clarity and stability and preparation thereof
  • Sedative and brain-invigorating oral liquid with improved clarity and stability and preparation thereof
  • Sedative and brain-invigorating oral liquid with improved clarity and stability and preparation thereof

Examples

Experimental program
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Effect test

example 1

[0175] Take 125g dried ginger, 625g Polygonum multiflorum, 500g Epimedium, 125g jujube, 62.5g licorice, 30g antler and vitamin B 1 5g is prepared according to the following method: the above seven flavors, the volatile oil extracted from dried ginger, the dregs and the prepared Polygonum multiflorum, Epimedium, Jujube, and licorice are decocted in water three times, the first time is 2 hours, the second and third times are 1 hour each, and the decoctions are combined , filtered, the filtrate was concentrated to a liquid extract, added ethanol to remove the precipitate, filtered, and the filtrate was used for later use; decoct the velvet antler with water for five times, the time was sequentially 4, 4, 3, 3, 2 hours, filtered in stages, and combined Concentrate the filtrate to 1 / 2 of the original drug, add beeswax, let stand until the wax layer is completely solidified, remove the wax layer, filter until clear; add 80% ethanol, stand at room temperature for 48 hours, filter, re...

example 2

[0177] Take 125g dried ginger, 625g Polygonum multiflorum, 500g Epimedium, 125g jujube, 62.5g licorice, 30g antler and vitamin B 1 5g is prepared according to the following method: the above seven flavors, the volatile oil extracted from dried ginger, the dregs and the prepared Polygonum multiflorum, Epimedium, Jujube, and licorice are decocted in water three times, the first time is 2 hours, the second and third times are 1 hour each, and the decoctions are combined , filtered, the filtrate was concentrated to a liquid extract, added ethanol to remove the precipitate, filtered, and the filtrate was used for later use; decoct the velvet antler with water for five times, the time was sequentially 4, 4, 3, 3, 2 hours, filtered in stages, and combined Concentrate the filtrate to 1 / 2 of the original drug, add beeswax, let stand until the wax layer is completely solidified, remove the wax layer, filter until clear; add 80% ethanol, stand at room temperature for 48 hours, filter, re...

example 3

[0179] Take 125g dried ginger, 625g Polygonum multiflorum, 500g Epimedium, 125g jujube, 62.5g licorice, 30g antler and vitamin B 1 5g is prepared according to the following method: the above seven flavors, the volatile oil extracted from dried ginger, the dregs and the prepared Polygonum multiflorum, Epimedium, Jujube, and licorice are decocted in water three times, the first time is 2 hours, the second and third times are 1 hour each, and the decoctions are combined , filtered, the filtrate was concentrated to a liquid extract, added ethanol to remove the precipitate, filtered, and the filtrate was used for later use; decoct the velvet antler with water for five times, the time was sequentially 4, 4, 3, 3, 2 hours, filtered in stages, and combined Concentrate the filtrate to 1 / 2 of the original drug, add beeswax, let stand until the wax layer is completely solidified, remove the wax layer, filter until clear; add 80% ethanol, stand at room temperature for 48 hours, filter, re...

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Abstract

The invention provides an Anshen Bunao Syrup with improved stability of clarity, which is prepared from effective ingredients extracted from zingiber, prepared fleeceflower root, epimedium herb, fructus zizyphi sativae, licorice root, hairy deerhorn and active ingredients in Vitamin B1 and auxiliary material. The Anshen Bunao Syrup is characterized in that: the auxiliary material contains a modifying agent with the stability of the clarity, the modifying agent is a non-aqueous polar solvent and one or more of polyethyleneglycol 200 to 8000, glycerol, 1, 2-propanediol and ethanol. The content of the Anshen Bunao Syrup is 500g to 5000g / 10000mL. In the invention, pH value is adjusted to 5 to 8 when the non-aqueous polar solvent is added into the Anshen Bunan Syrup, thus obviously improving the stability of the clarity of the Anshen Bunao Syrup without any sedimentation even for long time in storage.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medical preparation, in particular to Anshen Bunao Liquid. Background technique [0002] Anshen Bunao Ye is a Chinese patent medicine variety recorded in the Pharmacopoeia of the People's Republic of China (Part 1, 2005 Edition). B 1 5g is prepared according to the following method: extract the volatile oil of the above seven flavors, dried ginger, add water to decoct the medicinal dregs, Polygonum multiflorum, Epimedium, Jujube, and licorice three times, combine the decoctions, filter, concentrate the filtrate to a liquid extract, add Remove the precipitate with ethanol, filter, and use the filtrate for later use; decoct the velvet antler with water for five times, filter several times, combine the filtrate to concentrate, add beeswax, let stand until the wax layer is completely solidified, remove the wax layer, and filter with suction; add ethanol to remove the precipitate , filtere...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/08A61K47/10A61K47/34A61P25/00A61P25/20A61K31/51A61K35/32
Inventor 苏子仁赖小平陈建南
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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