Reverse engineering method for speculating source of medicament manufacturer
A manufacturer and pharmaceutical technology, applied in the field of drug analysis, can solve problems such as the effect of drug efficacy, and achieve the effect of eliminating errors
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Embodiment 1
[0066] A method for measuring the content of medium-chain fatty acid glycerides in pharmaceutical preparations, comprising the steps of:
[0067] 1. Preparation of pharmaceutical preparations for the test solution: Weigh about 0.5 g of the preparation to be tested that needs to be reverse engineered respectively, put it in a 100 mL reflux bottle, add 40 mL of methanol for proper ultrasonic dispersion, add 25 mg / mL methyl nonanoate solution ( Internal standard) 2.0mL, 6% sodium hydroxide methanol solution 0.5mL, reflux in water bath for 30min, take out, cool to room temperature, transfer to a separatory funnel, wash the reflux bottle with 20mL of n-hexane three times, and put the lotion into the separatory funnel Add water 40mL, shake vigorously to extract, stand to separate layers; extract the water layer twice with 20mL of n-hexane, and combine the n-hexane layer; wash with water twice, 20mL each time, take the n-hexane layer; Dry over sodium sulfate, filter, and take the fil...
Embodiment 2
[0090] A method for determining the source and content of medium-chain fatty acid glycerides in pharmaceutical preparations, comprising the following steps:
[0091] 1. Preparation of pharmaceutical preparations for the test solution: Weigh about 1.0 g of the preparation to be tested that needs to be reverse engineered respectively, put it in a 100 mL reflux bottle, add 40 mL of methanol for proper ultrasonic dispersion, add 25 mg / mL methyl nonanoate solution ( Internal standard) 2.0mL, 6% sodium hydroxide methanol solution 0.5mL, reflux in water bath for 40min, take out, cool to room temperature, transfer to a separatory funnel, wash the reflux bottle with 20mL of n-hexane three times, and put the lotion into the separatory funnel Add water 40mL, shake vigorously to extract, stand to separate layers; extract the water layer twice with 20mL of n-hexane, and combine the n-hexane layer; wash with water twice, 20mL each time, take the n-hexane layer; Dry over sodium sulfate, filt...
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