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Delivery device for a powder aerosol

A delivery device, aerosol technology, applied in the direction of nebulizer for treatment, medical device, inhaler, etc., can solve the problems of low dose and inapplicability, and achieve the effect of improving the problem of patient coordination

Inactive Publication Date: 2009-02-04
AIRPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, DPI is not suitable for pharmaceuticals that cannot be administered with a vehicle due to high dosing ratios, or cannot be further processed in this way
The problem with manufactured DPIs where the drug is administered with a carrier is that the amount of drug administered in inhalable form is low since the drug remains adhered to the carrier

Method used

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  • Delivery device for a powder aerosol
  • Delivery device for a powder aerosol
  • Delivery device for a powder aerosol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] The device according to the invention has been successfully used in the experimental veterinary treatment of respiratory disturbances in horses using Pumatane, as detailed below.

[0091] Horses are prone to a plethora of respiratory distress. Asthma is comparable to equine asthma, and both diseases share similar etiology and pathology. The disease has been shown to occur via a Th2 cytokine-driven mechanism in equines (Lavoie, J-P., Maghni, K., Desnoyers, M., Taha, R., Martin, J.G., and Hamid Q.A. (2001)) . Neutrophilic airway inflammation in horses with asthma is characterized by a Th2 cytokine profile (Am. J. Respir. Crit. Care. Med 164 1410-1413). Like their human counterparts, they have poor ease of use and have an estimated 2 range of enormous lung surface area.

[0092] The goal of this study was to investigate the use and delivery of thermally labile, hygroscopic anhydrous surfactants while ensuring acceptable physicochemical properties. The surfactant used ...

Embodiment 2

[0115] Study using Pumatan as a model drug figure 1 Performance of the inhaler shown in . Specifically, the effect of loading dose on dry powder delivery and the effect of tank pressure on atomization efficiency were investigated.

[0116] Reported clinical studies required a 4H 100 mg, 8 h 30 min dosing regimen prior to allergen challenge [Babu, KS. et al, ibid]. Such high doses were well tolerated, and in all cases early asthmatic responses were resolved. However, due to the proximity of pumatant to endogenous (endogenous) surfactants (eg, low transition temperature and high wet affinity), the energy required to atomize the powder cannot be achieved using conventional means.

[0117] Physical properties of Pumatan

[0118] Prior to in vitro testing, micronized pumatant was first characterized in terms of particle morphology, size distribution, hygroscopicity, and crystal structure.

[0119] The particle morphology of micronized pumatant (Jeol 6310: Jeol, Japan) was studi...

Embodiment 3

[0175] using a method called Zofac TM A device 300 of dry powder medicament was studied. Notably, a single actuation from a loading dose of approximately 100 mg of Zofac TM Deliver up to approximately 40 mg of Zofac in aerosol form in TM . Zofac TM It is composed of two synthetic phospholipids, dipalmitoylphosphatidylcholine (DPPC) and unsaturated phosphatidylglycerol (PG), at a ratio of 7:3. Zofac TM Has a mass median aerodynamic diameter of less than 5 microns. Zofac TM Contains not more than 4% moisture by weight. Of course, other dry powder medicaments can also be used with the device 300 .

[0176] The properties of the aerosol delivered via the device 300 were evaluated by Malvern laser diffraction and Andersen cascade impactors. The power source 305 is a nitrogen tank at 10 bar or 14 bar. Zofac delivered from a 100 mg loading dose at 10 bar and 14 bar is shown in Table 4 TM amount. It was observed that higher doses were delivered with the nitrogen tank at 14...

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PUM

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Abstract

A delivery device (10, 110, 300, 500) for a medicament includes: a housing (50), or a main body (310, 505), a receptacle (54, 600) holding a medicament in the form of a powder; and a source of propellant (53, 305), wherein the housing (50), or the main body (310, 505) provides an inlet (63, 380) and an outlet (55, 370) for the receptacle (54, 600), wherein the inlet (63, 380) is in fluid communication with the source of propellant (53, 305) and is directed against the medicament and the outlet (55, 370) is spaced from the medicament to allow aerosolization of the medicament; the device provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

Description

technical field [0001] The present invention relates to a hand-held delivery device for medicaments in powder form, typically an aerosol (aerosol) of powder particles. In particular, the delivery device can be used to deliver a medicament to the respiratory tract / lungs without a carrier. Background technique [0002] Two main types of hand-held devices for delivering aerosol medicaments to patients are known. These devices are propellant driven metered dose inhalers (MDI) and dry powder inhalers (DPI). [0003] In MDIs, the medicament is suspended or dissolved in a propellant. The propellant is provided in a pressurized tank with a metering valve which, upon activation, produces a single dose of the medicament in the form of a gas stream. The unit may include a wedge-shaped discharge nozzle baffle or venturi to accelerate particles through the discharge nozzle and remove oversized particles. Suitable halocarbons for use in MDI include low boiling hydrofluorocarbons, hydr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M15/00
CPCA61M15/0028A61M11/002A61M15/0005A61M15/0043A61M15/0065A61M2202/064A61M2205/8225A61M2206/14A61M2209/06
Inventor 罗伯特·普赖斯约翰·尼古拉斯·斯塔尼福思德里克·艾伦·伍德科克保罗·迈克尔·扬詹姆斯·A·伯恩斯J·妮塔·科格伯恩道格拉斯·R·多克霍恩罗伯特·J·多克霍恩埃德加·W·米切尔苏珊·J·普拉瑟
Owner AIRPHARMA
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