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Method for detecting cancer

A cancer, in vitro detection technology, applied in biochemical equipment and methods, microbial determination/inspection, etc., can solve problems such as being unsuitable for diagnosing breast cancer

Inactive Publication Date: 2009-02-11
BIOMERIEUX SA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients included in this study were all suspected of having breast disease ("Suspicious initial mammogram"), and this gene panel may not be suitable for routine testing to diagnose breast cancer prior to any mammography

Method used

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  • Method for detecting cancer
  • Method for detecting cancer
  • Method for detecting cancer

Examples

Experimental program
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Effect test

Embodiment Construction

[0151] 1. Characteristics of biological samples

[0152] The following examples are initially prepared from 92 blood samples (5 ml of whole blood, collected in two PaxGENE tubes). These samples set 37 blood samples from health control patients (H, from ETABLISSEMENT FRANCAIS DU SANG) and 55 patients from patients with stage I / II breast cancer (CI / II).

[0153] 2. Extract total RNA from blood samples

[0154] Collect blood samples directly in paxgene TM BLOOD RNA tube (Preanalytix, Hombrechtikon, CH). After the blood sampling stage, the tube was placed at room temperature for 4 hours, and then stored at -20 ° C until the biomaterial extraction. More precisely, in this program, use the PaxGene Blood RNA PRANALTIX, follow the manufacturer's instructions, extract the total RNA. In short, the test tube is centrifuged (15 minutes, 3000 g) to obtain a residue of nucleic acid (Culot, precipitate). The residue was rinsed and dissolved in a buffer containing the protease K required for d...

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Abstract

The invention concerns methods and compositions that can be used for detecting cancer in mammals, particularly humans. The invention particularly concerns serum markers of cancers and their use in diagnostic procedures. The invention also concerns tools and / or kits that can be used for carrying out these methods (reagents, probes, primers, antibodies, chips, cells, etc., the preparation thereof and their use. The invention can be used for detecting the presence or the progression of a cancer in mammals, particularly breast cancer including during early stages.

Description

Technical field [0001] The present application relates to methods and compositions that can detect mammals, especially in humans. It significantly describes the serum markers of cancer and their application in diagnostic methods. It also relates to tools and / or kits (reagents, probes, primers, antibodies, chips, cells, etc.) that can be used to implement these methods, and their preparations and their applications. The present invention can be used to detect cancer in mammals, especially breast cancer (including its early). Background technique [0002] In women, breast cancer is the primary reason for cancer death in industrialized countries. Age is the most important risk factor. In Western countries, every year, risk increased by 0.5%. Other risk factors are known, such as the number of pregnancy and the initial pregnancy, breastfeeding, adolescence and menopausal, sudden postmenopausal estrogen treatment, stress and nutrition. [0003] Diagnosis of breast cancer is usually ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158
Inventor 亚历山大·克劳泽菲利普·莱斯纳马利克·帕耶布鲁诺·穆然法比安·施魏格霍费尔劳伦特·布拉科
Owner BIOMERIEUX SA
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