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Uses of synthesis of 2-hydroxyl malonic carbonyl compounds in synthesis of flavonols

A technology of hydroxypropanedicarbonyl and flavonols, applied in organic chemistry and other fields, can solve problems such as large-scale industrial production that cannot be solved

Inactive Publication Date: 2009-02-18
张锋
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Can not solve the problem of large-scale industrial production

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  • Uses of synthesis of 2-hydroxyl malonic carbonyl compounds in synthesis of flavonols
  • Uses of synthesis of 2-hydroxyl malonic carbonyl compounds in synthesis of flavonols
  • Uses of synthesis of 2-hydroxyl malonic carbonyl compounds in synthesis of flavonols

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Embodiment Construction

[0012] The present invention will be further described below in conjunction with technical solutions.

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Abstract

The present invention relates to a preparation method of thi-disaccharide compounds. The preparation method comprises the following steps: the thi-disaccharide compound is nitrosylated, reduced with zinc powder-acetic acid, hydrolyzed and processed through diazo reaction to produce 2-hydroxyl thi-disaccharide compounds. The present invention is suitable for synthesizing the myricetin and other types of flavonol medicine and the 2-hydroxyl malonic acid.

Description

technical field [0001] The invention relates to a preparation method of a medicine containing 2-hydroxyl of malonate or propanedicarbonyl compounds, in particular to the synthesis of a natural product flavonol compound such as myricetin. Background technique [0002] Myricetin (Myricetin) synonym myricetin, myricetin, myricetin, Myricetol, Cannabiscetin. It is mainly a kind of polyhydroxy flavonol compound isolated and purified from the bark of Myrica nagi (Myrica nagi) and bark of Myrica nagi (M.rubra). 4',5',-Hexahydroxyflavone (3,5,7,3',4',5'-Hexahydroxyflavone). It has antibacterial, anticancer, enzyme inhibitory, hypoglycemic, platelet activating factor antagonism, liver protection and other effects, and also inhibits the release and metabolism of arachidonic acid induced by rat peritoneal macrophage ionophores; Strong antigonadotropic and antitussive expectorant and diuretic effects. [0003] Myricetin is brownish-yellow needle crystal, mp324℃~326℃, soluble in metha...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/28
Inventor 张锋
Owner 张锋