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Sample analyzer and sample analysis method

A technology for analyzers and output parts, which is applied in the field of sample analyzers and sample analysis, and can solve problems such as mode jumps and failure to maintain multi-mode vibration modes

Active Publication Date: 2011-12-07
SYSMEX CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, with the technology described in the above-mentioned Patent Publication No. Heisei 9-178645 and U.S. Patent No. 5,946,333, once the laser diode ages for a long time, it may not be able to maintain the multi-mode oscillation mode, resulting in mode hopping.

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  • Sample analyzer and sample analysis method

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Embodiment Construction

[0035] [Overall structure of the sample analyzer]

[0036] First, the overall configuration of a sample analyzer 1 according to one embodiment of the present invention will be described with reference to FIG. 1 . This sample analyzer 1 is a multiple automatic blood analyzer for blood tests, but in the following description, only the measurement of leukocytes, reticulocytes and platelets in blood will be described.

[0037] As shown in FIG. 1 , a sample analyzer 1 is composed of a measuring device 2 for measuring blood as a biological sample, and a data processing device 3 as an analysis device for analyzing measurement data output from the measuring device 2 to obtain an analysis result. The measuring device 2 can measure white blood cells, reticulocytes and platelets in blood by using flow cytometry. The so-called flow cytometry is a particle (blood cell) measurement method, that is, while forming a sample flow containing a measurement sample, the sample flow is irradiated w...

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Abstract

The present invention provides a sample analyzer capable of automatically and stably oscillating laser diodes in multiple modes, including: an LD laser diode 501d for irradiating laser light on the sample, a PD photodiode 501e for detecting the luminous amount of the LD501d, and a laser diode 501e detected according to the PD501e. APC circuit 501b that outputs direct current to LD501d to keep the light emission of LD501d at a certain level, high-frequency oscillation circuit 501f that superimposes high-frequency components on the direct current output from APC circuit 501b, and controls high-frequency oscillation circuit 501f according to the magnitude of direct current output from APC circuit 501b The output high-frequency amplitude is the high-frequency automatic adjustment circuit 501c that makes LD501d multi-mode oscillate. The present invention also provides a sample analysis method for analyzing a sample by irradiating laser light from a laser diode to the sample with a current superimposed with a high-frequency component.

Description

Technical field: [0001] The invention relates to a sample analyzer and a sample analysis method for measuring components of biological samples such as blood. Background technique: [0002] A sample analyzer for measuring the size of platelets in blood such as blood platelets using laser diode flow cytometry has been disclosed in US Patent No. 6,525,807. For accurate measurements of this kind of analyzer, the laser diode noise must be very low. [0003] Once the laser diode emits light continuously, it will switch to a single-mode oscillation mode (oscillation mode with a single wavelength). However, due to changes in the magnitude of the current supplied to the laser diode and changes in the temperature of the laser diode, the oscillation wavelength of the laser diode may change to another wavelength in single-mode oscillation (hereinafter also referred to as "mode hopping"). Once a mode hop occurs, the amount of light emitted by the laser diode changes, and this change in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01G01N33/48G01N15/14H01S5/06
CPCG01N2201/0692G01N2015/0084G01N2015/0073G01N2015/008H01S5/0653G01N2201/0612H01S5/06832G01N15/1434H01S5/0622G01N15/1459H01S5/0427H01S5/0652G01N2201/0697G01N2015/012G01N2015/016G01N2015/018
Inventor 植野邦男
Owner SYSMEX CORP