Novel coumarin derivative having antitumor activity

Abstract

The present invention provides a compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof. Because of having a sufficiently high antitumor activity, this compound or its salt is useful as a remedy for cell proliferative diseases, in particular, cancer. It is also intended to provide a medicinal composition which contains the above-described compound or its salt as the active ingredient. [Chemical formula 1] (1) wherein X is selected from heteroaryl, etc.; Y<1> and Y<2> are selected from -N=, etc.; Y<3> and Y<4> are selected from -CH=, etc.; A is selected from sulfamide, etc.; R<1> is selected from hydrogen, etc.; and R<2> is selected from C1-6 alkyl, etc.

Description

technical field [0001] The invention relates to a novel coumarin derivative with anti-tumor activity and a pharmaceutical composition using it as an active ingredient, especially a therapeutic agent for cell proliferation diseases. Background technique [0002] It is known that coumarin derivatives, that is, compounds derivatized at various positions using a coumarin skeleton as a core, have various pharmacological effects depending on the position of chemical modification (Non-Patent Document 31). For example, warfarin having an antithrombotic effect is widely known as a drug having a coumarin skeleton (Non-Patent Document 1). In addition, coumarin derivatives that act on various target proteins and have anti-tumor activity, or inhibit proteins related to anti-tumor activity, can be obtained by chemically modifying different positions of the mother nucleus. [0003] In addition, coumarin derivatives exhibiting antitumor activity by inhibiting steroid sulfatase have been re...

AI Technical Summary

Problems solved by technology

[0009] Thus, although some coumarin derivatives having antitumor activity are known, there are few compounds showing antitumor activity as high as a practical level as an anticancer agent.

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