Gamma-ethyl linolenate soft capsule and preparation thereof

A technology of ethyl linolenic acid and preparation process, which can be applied to medical preparations containing active ingredients, plant raw materials, cardiovascular system diseases, etc., can solve the problems affecting the quality of refined oil, easy loss of value components, etc. The effect of carrying, improving stability and high separation efficiency

Inactive Publication Date: 2009-04-08
沙丽塔娜特·吐尔干
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AI Technical Summary

Problems solved by technology

High temperature desolventization and deodorization are required, and valuable components are easily lost, thus affecting the quality of refined oil

Method used

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Embodiment Construction

[0010] This gamma-linolenic acid ethyl ester soft capsule, the shell of the soft capsule is made of gelatin, and the composition in the soft capsule is evening primrose oil, vitamin E oil, glycerin, and its proportioning is evening primrose oil:vitamin E oil: Glycerol = 398:2:57.

[0011] The preparation process of the above gamma-linolenate soft capsules, in the first step, 50kg of evening primrose seeds are crushed and put into two 100L extraction kettles, the extraction temperature is controlled at 45°C, and the flow rate is controlled at 200L / H. The kettle extraction time is 3 hours, the pressure is controlled at 20Mpa, and the two extraction kettles are switched once every three hours to obtain evening primrose oil in the separation kettle; in the second step, evening primrose oil, vitamin E oil, and glycerin are mixed in a ratio of 398:2: The proportion of 57 is evenly mixed; the third step is to fill the mixture of evening primrose oil, vitamin E oil and glycerin into t...

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Abstract

The invention discloses a gama-linolenic acid ethyl soft capsule and a process for preparing the same. The components in the soft capsule comprise evening primrose oil, vitamin E oil, and glycerin with the proportion being 392 to 2 to 57. The process for preparing the soft capsule comprises the following: step one, preparing the evening primrose oil through a supercritical extraction method; step two, uniformly mixing the evening primrose oil, the vitamin E oil, and the glycerin according to the proportion of 392 to 2 to 57; and step three, filling the mixture into capsule shells according to the standard that each capsule contains 400 milligrams of content. The stability of gama-linolenic acid can be improved through esterification treatment; the vitamin E is added into the soft capsule to improve the product stability and prevent the soft capsule from being oxidized; the form of soft capsule can separate the content from the external aerobic environment and is convenient to take and carry around. The process adopts the supercritical extraction method to extract the evening primrose oil, thus the preparation process has the advantages of short extraction time, high separation efficiency, low operation temperature, and no solvent pollution.

Description

technical field [0001] The invention relates to a gamma-linolenic acid ethyl ester soft capsule and a preparation process thereof. Background technique [0002] Evening primrose, also known as evening primrose and mountain sesame, is a 2-year-old herb of the willow leaf family. Its origin is North America, and it was successfully introduced and cultivated in my country. Mature evening primrose seeds are small, dark brown, irregular in shape, and have sharp angles on the surface. The crude fiber content is 40%, the oil content is 22-30%, and the fatty acid composition is 7% of gamma-linolenic acid. 80% linoleic acid, 8% oleic acid, 5% palmitic and stearic acids. Evening primrose is a new type of oil rich in polyunsaturated fatty acids, and its content of gamma-linolenic acid is relatively high. γ-linolenic acid is a highly unsaturated fatty acid that cannot be synthesized by the human body and has important physiological activities. It is closely related to maintaining the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/66A61K31/215A61K36/185A61P9/10
Inventor 沙丽塔娜特·吐尔干
Owner 沙丽塔娜特·吐尔干
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