Propolis chawing pieces and processing technique

A chewable tablet and propolis technology, applied in the field of propolis chewable tablet and production technology, can solve the problems of unacceptable, unsuitable for long-term use, chewable tablet containing, etc., and achieves the effect of strong throat clearing effect, no toxicity and side effects, and favorable dissolution effect.

Active Publication Date: 2009-04-22
NANJING LAOSHAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most throat clearing products in the market are medicines and should not be taken for a long time
Propolis has a strong unique smell. If it is not effectively covered up, it will lead to bad taste, which is difficult for ordinary people to accept. Existing technology can only be made into oral tablets for oral administration, the smell is heavy and unacceptable when chewed in the mouth, and the body temperature will quickly soften and agglomerate the propolis and stick to the teeth, so it cannot be made into chewable tablets and melted in the mouth

Method used

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  • Propolis chawing pieces and processing technique
  • Propolis chawing pieces and processing technique
  • Propolis chawing pieces and processing technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Recipe: (weight)

[0035] Propolis 35.0%, micronized silica gel 1.0%, microcrystalline cellulose 23.4%, mannitol 20.0%, lactose 20.0%, menthol 0.5%, aspartame 0.1%;

[0036] Production process: mix the ethanol extract of propolis with micropowder silica gel, then freeze to -20°C, keep the crushing temperature at -20°C, and then mix it with other materials except menthol by equal increment method, and then add the volume concentration of 85% ethanol solution is used as wetting agent, adopts conventional method, carries out wet granulation, crosses 15 mesh sieves, then is dried at 40 ℃, when moisture weight content reaches 5%, is cooled to room temperature, adds menthol, mixes After pressing into tablets, the propolis chewable tablets are made.

[0037] The adding amount of ethanol solution is 8% of propolis ethanol extract weight.

Embodiment 2

[0039] Recipe: (weight)

[0040] Propolis extract 39%, micronized silica gel 0.5%, microcrystalline cellulose 25%, mannitol 10%, lactose 25%, menthol 0.4%, aspartame 0.1%.

[0041] The preparation method is the same as in Example 1. Wherein, the freezing temperature is 0°C.

Embodiment 3

[0043] Adopt the method stipulated in " Pharmacopoeia of the People's Republic of China " and " Health Food Inspection and Evaluation Technical Specification ", the propolis chewable tablet of embodiment 1 and embodiment 2 is detected, and the results are as follows:

[0044] The test report investigates the dissolution rate of flavonoids with throat-clearing effect, and determines whether the functional ingredients of the product are released quickly and effectively dissolved by measuring the flavonoid content in the product solution within 30 minutes.

[0045] Table 1 Example 1 sample flavonoid dissolution testing results

[0046]

[0047]

[0048] Table 2 Example 2 sample flavonoid dissolution testing results

[0049]

[0050] Toxicological safety evaluation report results: the rat acute toxicity test (LD50) of Laoshan brand propolis chewable tablets is >21500mg / kg, which is non-toxic; the results of Ames test, mouse bone marrow PCE micronucleus test and mouse sper...

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Abstract

The invention provides a propolis chewable tablet and a production process thereof. The propolis chewable tablet comprises the following compositions in weight percentage: 30 to 40 percent of a propolis extract, 0.5 to 2 percent of micropowder silica gel, 20 to 25 percent of microcrystalline cellulose, 10 to 25 percent of mannite and 15 to 25 percent of lactose. The propolis chewable tablet has the advantages that the propolis chewable tablet has strong efficacy of clearing heat from throat, has no toxicity or side effect, has various health-care efficacies, can be taken for a long time and has good mouthfeel. In the formula, the addition amount of the propolis reaches as high as 35 percent; as the method of adding the micropowder silica gel to adsorb and wrap the propolis in refrigeration and ultramicro pulverization is adopted, alcohol is adopted as a humectant in pelletization and can not cause the problem that the propolis is dissolved and agglomerated when the propolis meets the alcohol; after the tablet is chewed, propolis particles can be effectively dispersed, are favorable for functional compositions to dissolve out; at the same time, the unique flavor of the wrapped propolis is effectively concealed.

Description

technical field [0001] The invention relates to a propolis health food and a production method thereof. Background technique [0002] Propolis is the resin, sap, plant pigments and volatile oil collected by worker bees from specific parts of trees and other plants, mainly new shoots, axillary buds or bark, and mixed with the secretions of their mandibular glands and wax glands, which are repeatedly processed by bees. Aromatic colloidal solids. Propolis contains a concentrate of a large number of active ingredients similar to glue source plants, has a variety of biological, physiological and pharmacological activities, and is a natural health care product with a wide range of applications. [0003] The basic components of propolis are: 39% to 53% of resin tree fragrance compound, 12% to 17% of polyphenols, 2% to 3% of polysaccharides, and 8% to 12% of impurities. Modern scientific analysis, a variety of chemical components isolated from propolis, proves that the composition...

Claims

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Application Information

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IPC IPC(8): A23L1/076A23L1/29A23L21/20A23L33/00
Inventor 陈坤林德祥邵飞
Owner NANJING LAOSHAN PHARMA
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