Method for preparing ginkgo leaf extract powder using supercritical liquid desiccation and device thereof

A technology of supercritical fluid and ginkgo biloba, which is applied in the direction of drying solid materials, making medicines into special physical or ingestible devices, and medical raw materials derived from ginkgo biloba. Problems such as destruction and carbon dioxide waste, achieve the effect of small average particle size, narrow particle size distribution, and reduced consumption

Inactive Publication Date: 2009-05-20
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims at the disadvantages that the active ingredients in the high-temperature drying method are easily destroyed, and the supercritical drying is not easy to control, and the waste of carbon

Method used

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  • Method for preparing ginkgo leaf extract powder using supercritical liquid desiccation and device thereof
  • Method for preparing ginkgo leaf extract powder using supercritical liquid desiccation and device thereof

Examples

Experimental program
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Embodiment 1

[0022] A method for preparing Ginkgo biloba extract powder by drying with supercritical fluid is realized by a supercritical drying device with carbon dioxide recycling. The raw material is an alcohol solution of 130 g of Ginkgo biloba extract containing 90% wt of alcohol. The pressure of supercritical carbon dioxide in the drying chamber cylinder 7 needs to be controlled at 10 MPa. The heater 6 heats the hot water in the drying chamber cylinder 7 and the primary separation cylinder 8, and the hot water jacket of the secondary separation cylinder 9 The temperature in the drying chamber cylinder 7 is controlled at 40°C, the temperature in the first-stage separation cylinder 8 is controlled at 30°C, and the temperature in the second-stage separation cylinder 9 is controlled at 20°C. After opening the valve, the temperature from the carbon dioxide cylinder 1 The carbon dioxide is cooled to 0°C-5°C through the refrigerating unit 3, and then continuously delivered to the drying chamber...

Embodiment 2

[0025] A method for preparing Ginkgo biloba extract powder by drying with supercritical fluid. The alcohol solution of Ginkgo biloba extract without impurities is placed in a sealed drying chamber, and then carbon dioxide is introduced at a flow rate of 20L / h. The temperature is 0°C, the cylinder pressure of the drying chamber is controlled at 13MPa and the temperature is 60°C. After the carbon dioxide becomes a stable supercritical fluid, it is then continuously replaced and dried for 4 hours to obtain a pale yellow ginkgo leaf extract dry product powder. When the carbon dioxide in the drying chamber becomes a stable supercritical fluid, start the primary and secondary separation cylinders, and control the pressure of the primary and secondary separation cylinders to 3.5MPa and the temperature to 20°C. The alcohol in the alcohol solution of Ginkgo biloba extract can be recycled and reused. After the used carbon dioxide is separated from the alcohol in the gas-liquid separator, it...

Embodiment 3

[0029] A method for preparing Ginkgo biloba extract powder by drying with supercritical fluid. The alcohol solution of Ginkgo biloba extract without impurities is placed in a sealed drying chamber, and then carbon dioxide is introduced at a flow rate of 45L / h. The temperature is 5°C, the cylinder pressure of the drying chamber is controlled at 30MPa and the temperature is 75°C. After the carbon dioxide becomes a stable supercritical fluid, it is then continuously replaced and dried for 8 hours to finally obtain a pale yellow ginkgo leaf extract dry product powder. When the carbon dioxide in the drying chamber becomes a stable supercritical fluid, start the primary and secondary separation cylinders, and control the pressure of the primary and secondary separation cylinders to 5.0MPa and temperature to 40°C. The alcohol in the alcohol solution of Ginkgo biloba extract can be recycled and reused. After the used carbon dioxide is separated from the alcohol in the gas-liquid separator...

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Abstract

The invention discloses a method for preparing ginkgo leaf extract powder by drying supercritical fluid and a device thereof. The method comprises the following steps: placing alcoholic solution of ginkgo leaf extract without impurity into a sealed dry chamber cylinder body, and then introducing carbon dioxide into the solution at a flow speed of 20 to 45 liters per hour, wherein temperature of the carbon dioxide is between 0 and 5 DEG C; controlling pressure of the dry chamber cylinder body at 10 to 30MPa and temperature of between 35 and 75 DEG C; and after the carbon dioxide becomes stable supercritical fluid, continuously displacing and drying the fluid for 4 to 8 hours to finally obtain light-yellow dry finished powder of the ginkgo leaf extract. The device comprises a carbon dioxide steel bottle, a gas-liquid separation container, a gas cooling unit, a transition container, a carbon dioxide transfer pump, a heater, the dry chamber cylinder body, a first-stage separation cylinder body, a second-stage separation cylinder body, valves and pipelines, and the components are mutually connected through the valves and the pipelines. The content of flavone in obtained power is more than 25 weight percent, the alcoholic solution in the extract can be reclaimed, and the carbon dioxide can also be recycled.

Description

Technical field [0001] The invention relates to a method for drying ginkgo biloba extract, in particular to a method for preparing ginkgo biloba extract powder by drying using supercritical fluid. Background technique [0002] Ginkgo is a deciduous tree with a height of 40m. There are two types of branches, long and short. The leaves grow in clusters on short branches and alternate on long branches. The blades are fan-shaped, 4-8cm long, 5-10cm wide, 2 lobed in the middle of the tip, wedge-shaped at the base, parallel veins, and bifurcated. "Compendium of Materia Medica" records that its leaves have high medicinal value. They are sweet, bitter and astringent in nature and enter the lung and kidney meridians, and have the effects of relieving asthma and relieving cough, stopping turbidity, and reducing stool. The ingredients of Ginkgo biloba include unique flavonoids, terpenes and ginkgolic acid that can cause allergic reactions. These ginkgo flavonoids-glycosides have powerful an...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61J3/02F26B5/16A61K127/00
Inventor 黄立新王成章廖传华
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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