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Chinese medicine granule containing agastache extract and preparation method thereof

A technology of Huoxiang extract and traditional Chinese medicine granules, which is applied in the directions of medical formulations containing active ingredients, pharmaceutical formulations, and medical formulations with non-active ingredients, etc. question

Active Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Extraction of extract: take 160g of Atractylodes atractylodes, 160g of tangerine peel, 160g of Magnolia officinalis (made from ginger), 240g of Angelica dahurica, 240g of Poria cocos, 240g of Dabupi, 160g of raw pinellia, 13.5g of dried ginger, 20g of licorice extract, and 1.6g of patchouli oil. ml, perilla leaf oil 0.8ml for later use: take 160g of herb, 160g of tangerine peel, 160g of Magnolia officinalis (made from ginger), 240g of Angelica dahurica, 240g of Poria cocos, 240g of Dabupi, 160g of raw pinellia, 13.5g of dried ginger, 20g of licorice extract , patchouli oil 1.6ml, perilla leaf oil 0.8ml for later use:

[0046] Atractylodes atractylodes, tangerine peel, Magnolia officinalis officinalis, Angelica dahurica are respectively according to the percolation method under Chinese Pharmacopoeia 1995 edition one appendix I0 liquid extract and extract, use 60% ethanol as solvent, carry out percolation after soaking for 24 hours, collect percolation liquid , recover et...

Embodiment 2

[0050]Extraction of extract: 80g of herb, 80g of tangerine peel, 240g of Magnolia officinalis, 120g of Angelica dahurica, 360g of Poria cocos, 120g of Dabupi, 80g of raw pinellia, 10g of licorice extract, 0.8ml of patchouli oil, and 0.4ml of perilla leaf oil for later use; Cangzhu, Tangerine Peel, Magnolia officinalis, and Angelica dahurica were respectively according to the percolation method under the liquid extract and extract of the Chinese Pharmacopoeia, using 50% ethanol as a solvent, and percolating after immersion for 12 hours, collecting the percolation liquid, recovering ethanol, and medicinal solution Reserve; boil the poria cocos in water, soak twice at 60°C, the first time for 1.5 hours, and the second time for 1 hour, and take the juice; soak the raw pinellia in cold water, change the water every 8 hours, soak until the heart is thoroughly soaked, and then Add 8g of dried ginger, add water and decoct twice, the first time is 1.5 hours, and the second time is 1 hou...

Embodiment 3

[0054] Extraction of extract: 240g of herb, 240g of tangerine peel, 80g of Magnolia officinalis, 120g of Angelica dahurica, 360g of Poria cocos, 360g of Dabupi, 240g of raw pinellia, 10g of licorice extract, 2.4ml of patchouli oil, and 0.5ml of perilla leaf oil for later use; Atractylodes atractylodes, dried tangerine peel, Angelica dahurica, Magnolia officinalis add 45% ethanol and reflux extraction twice, each time 4 hours, combine extract solution, filter, recover ethanol, set aside; For the percolation method under the extract, use 50-80% ethanol as a solvent, soak for 36 hours and then carry out percolation, collect the percolation liquid, recover ethanol, and prepare the medicinal solution; Take the juice for 4.5 hours for the first time, and 3 hours for the second time; soak the raw pinellia in cold water, change the water every 8 hours, soak until it is thoroughly soaked, add 20g of dried ginger, add water to decoct twice, the first time 4.5 hours, 3 hours for the seco...

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Abstract

The invention provides a traditional Chinese medicine granular preparation with ageratum extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing Huoxiang extract and a preparation method thereof. Background technique [0002] The prescription of Huoxiang Zhengqi comes from Huoxiang Zhengqi Powder contained in "Taiping Huimin Hejiju Prescription Volume 2". Tangerine peel, bellflower, licorice. It has the effect of resolving the exterior, harmonizing the middle, and aromatizing the turbidity. It is mainly used for exogenous wind-cold, internal stagnation of dampness or feeling of heat-dampness, external symptoms such as cold and heat headache, internal chest and abdomen fullness, nausea, nausea, abdominal pain and diarrhea , greasy moss in the mouth, moist and slow pulse and other signs of damp resistance. This prescription is often used for those with the above syndromes such as gastrointestinal cold, acute gastroenteritis or i...

Claims

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Application Information

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IPC IPC(8): A61K36/532A61K36/8888A61K9/16A61K47/02A61K47/36A61K47/38A61K47/40A61P1/12A61P31/00
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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