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Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion

A technology of traditional Chinese medicine preparation and traditional Chinese medicine, applied in the field of medicine, can solve the problems of high requirements for aseptic operation, high irritation, limited extraction technology, etc.

Inactive Publication Date: 2009-06-10
NAN FANG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insufficient: irritating, bring the chance of infection
Insufficient: immunosuppression, affecting wound healing, etc.
Insufficient: the effective dose affects wound healing, the extraction technology is limited, and the price is expensive
Disadvantages: high requirements for aseptic operation, easy to cause infection, insufficient clinical compliance
Insufficient: main clinical prescriptions and hospital preparations, no marketed products

Method used

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  • Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion
  • Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion
  • Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052]The preparation process of the oral liquid dosage form is as follows: take 25 kg of Salvia miltiorrhiza, extract twice with 70% ethanol under reflux, each time for 1 hour, filter, and use the filtrate for later use. The dregs were combined with 25kg of astragalus, 15kg of Glauber's salt, 15kg of Citrus aurantii, 5kg of angelica, and 5kg of woody incense, decocted twice for 3.5 hours each time, and 200ml of aromatic water was collected at the same time, and stored in another container for later use. The combined water extracts were concentrated to a relative density of about 1.17 (50°C), and the alcohol extract and 95% ethanol were added to make the alcohol content reach 60%, refrigerated for 24 hours, and centrifuged. After recovering ethanol from the supernatant, add an appropriate amount of water to the concentrate, refrigerate for 24 hours, and centrifuge. Add aromatic water and simple syrup to the supernatant to adjust the pH to 5.0-7.0, and add distilled water to 10...

Embodiment 2

[0054] The preparation process of the oral liquid dosage form is as follows: take 15 kg of Salvia miltiorrhiza, extract twice with 70% ethanol under reflux, each time for 1 hour, filter, and use the filtrate for later use. Combine dregs with astragalus 15kg, Glauber's salt 5kg, Citrus aurantium 5kg, Angelica 1kg, Woody 1kg, decoct in water twice for 3.5 hours each time, collect 200ml of aromatic water at the same time, and save it in another device for later use. The combined extracts were concentrated to a relative density of about 1.17 (50°C), the alcohol extract and 95% ethanol were added to make the alcohol content reach 60%, refrigerated for 24 hours, and centrifuged. After recovering ethanol from the supernatant, add an appropriate amount of water to the concentrate, refrigerate for 24 hours, and centrifuge. Add aromatic water and simple syrup to the supernatant to adjust the pH to 5.0-7.0, and add distilled water to 1000ml. Filtration, potting, sterilization, that is. ...

Embodiment 3

[0056] The preparation process of the oral liquid dosage form is as follows: take 25 kg of Salvia miltiorrhiza, extract twice with 70% ethanol under reflux, each time for 1 hour, filter, and use the filtrate for later use. Combine dregs with 25kg of Codonopsis pilosula, 15kg of senna leaves, 15kg of Citrus aurantii, 5kg of Rhizoma Cyperi, and 5kg of Corydalis Corydalis, decoct in water twice for 3.5 hours each time, collect 200ml of aromatic water at the same time, and store them in another container for later use. The combined water extracts were concentrated to a relative density of about 1.17 (50°C), and the alcohol extract and 95% ethanol were added to make the alcohol content reach 60%, refrigerated for 24 hours, and centrifuged. After recovering ethanol from the supernatant, add an appropriate amount of water to the concentrate, refrigerate for 24 hours, and centrifuge. Add aromatic water and simple syrup to the supernatant to adjust the pH to 5.0-7.0, and add distilled ...

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Abstract

The invention discloses a pharmaceutical composition for preventing belly postoperative adhesion and preparation method thereof. The pharmaceutical composition consists of astragalus or Radix Codonopsis, red sage root, banksia rose, bitter orange, rheum officinale or senna leaf, saltcake, magnolia cortex, Chinese angelica and licorice. The composition is prepared by: decocting by water, collecting the volatile oil; removing the residues; concentrating the extract, adding 95% ethanol to raise the alcohol content to 40-60%; leaving statically for 24 hours; centrifuging, removing deposition, recovering ethanol from supernatant and adding volatile oil. And the medicine can be made into oral liquid, tablet, soluble granules, capsule and injection by adding pharmaceutics acceptable auxiliary materials according to common technology. The composition achieves the effects of supplementing qi, removing blood stasis, promoting qi circulation and clearing hollow viscera, can be used for treating belly postoperative adhesion which belongs to qi-deficiency blood stasis qi stagnation hollow viscera filled disease.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine preparation for preventing and treating postoperative adhesion. Background technique [0002] Postoperative adhesion is a common complication after surgery, with an incidence rate as high as 90% or more, and a clinical incidence rate as high as 40%. The rate is as high as 9.7%), which is one of the difficulties in the prevention and treatment of common clinical diseases. At present, there is no drug specifically for the prevention and treatment of postoperative adhesions in China. At present, the prevention and treatment of postoperative adhesion mainly starts from the following aspects: [0003] 1. Reduce tissue damage: Gentle operation, meticulous hemostasis, adequate lavage to prevent foreign body residues, etc. Insufficient: Tissue damage is inevitable. [0004] 2. Prevention of local tissue ischemia: Procaine was used intraperitoneally to dilate blo...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K36/8905A61K36/537A61K9/08A61K9/10A61K9/16A61K9/20A61P41/00A61K33/04
Inventor 侯连兵罗仁杨西晓王春霞郭丹谭亚非石汉平
Owner NAN FANG HOSPITAL
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