Continuous current micro-reactor and preparation method and use thereof

A microreactor and reaction technology, applied in chemical instruments and methods, chemical/physical/physical chemical processes, chemical/physical processes, etc., can solve the problems of slow synthesis speed, lack of economy and environmental protection, low synthesis efficiency, etc.

Inactive Publication Date: 2009-06-10
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional heating and stirring reactors have disadvantages such as slow synthesis speed, low synthesis efficiency, lack of economy and environmental protection, and large-scale synthesis requires pilot test and process parameter optimization when performing organic synthesis and drug activity screening.

Method used

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  • Continuous current micro-reactor and preparation method and use thereof
  • Continuous current micro-reactor and preparation method and use thereof
  • Continuous current micro-reactor and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Fabrication of serpentine double-helix capillary reaction tube

[0026] Use a glass capillary with an inner diameter of 100 μm-1000 μm and an outer diameter of 250 μm-1500 μm (or a capillary made of different materials such as quartz, stainless steel, or polytetrafluoroethylene), on a self-made capillary winding instrument, etc. When the temperature rises to a certain value, spiral winding is carried out from bottom to top, the number of spirals is any number between 10-100 turns, and the inner diameter of each turn is the same, which is between 1cm-10cm, and then spiral winding is carried out from top to bottom The number of spirals is still 10-100 circles, and the inner diameter of each circle is the same, which is between 1.5cm-20cm. The same capillary is used in the whole winding process. After the winding is completed, it is slowly cooled in the air to form a serpentine double-helix capillary reaction tube. The reaction tube has an inlet and an outlet a...

Embodiment 2

[0027] Embodiment two: the making of Y type or T type micro-mixer

[0028] Use a glass capillary with an inner diameter of 100 μm-1000 μm and an outer diameter of 250 μm-1500 μm, and sinter it into a Y-shaped or T-shaped tube on an alcohol blowtorch to make it a Y-shaped or T-shaped tee tube. The length of each channel Both are between 5mm-25mm. The miniature tee is a Y-type or T-type micro-mixer.

Embodiment 3

[0029] Embodiment 3: optical detector tracking reaction process

[0030] A three-way valve is installed at the inlet end and the outlet end of the serpentine double-helix capillary reaction tube, and a hose is respectively connected to the three-way valve, and the hose is respectively connected with the sample pool in the optical detector. After the reaction is completed, the inlet and outlet samples of the serpentine double-helix capillary reaction tube are collected for online detection, and the degree of the reaction is determined by comparing the changes in the spectral data before and after the reaction.

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Abstract

The invention relates to a continuous flow micro-reactor for medicine and fine chemical production and preparation and application thereof. The invention belongs to the technical field of the micro-reactor and preparation and application thereof. The reactor device consists of a liquor storage tank, a constant flow pump, a micro-mixer, serpentiform double helix capillary reaction pipes, an optical detector, a constant temperature bath and a connecting duct. The continuous flow micro-reactor is capable of making a reactant move back and forth continuously and spirally in the internal and external path coiled reaction pipes, thereby avoiding the phenomenon of local overheating for the reaction in the prior reactor vessel. The invention also provides a preparation method for the reactor and a method for synthesizing chalcone compounds through the reactor. The continuous flow micro-reactor has the advantages of compact structure, simple preparation, convenient use, high reaction efficiency, low power consumption, little pollution, and the like. The continuous flow micro-reactor can carry out continuous production and on-line tracking of the reaction process and has bright market prospect.

Description

technical field [0001] The invention relates to a continuous-flow microreactor for medicine and fine chemical production and its preparation and application, and belongs to the technical field of microreactor and its preparation and application. Background technique [0002] Traditional heating and stirring reactors have disadvantages such as slow synthesis speed, low synthesis efficiency, lack of economy and environmental protection, and large-scale synthesis requires pilot test and process parameter optimization when performing organic synthesis and drug activity screening. Since the 1990s, the chemical reactions in microchannels have been studied, resulting in microreactors. A microreactor usually refers to a new type of microchemical reactor manufactured by applying micromachining technology. The cross-sectional diameter of the microchannel in the reactor is generally about 50-1000 microns. According to different feeding modes, it can be divided into continuous flow mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00
Inventor 王世范周丽君杨凯陈小花
Owner HAINAN UNIVERSITY
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