Gel composition for eyes and preparation method thereof

A kind of technology of ophthalmic gel and composition

Active Publication Date: 2009-06-17
杨文龙
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the patent uses poloxamer 407 and 188, which are very expensive pharmaceutical excipients, and the implementation process of the invention is also relatively complicated, so further research and development of new ophthalmic gel process methods are required
[0014] At present, there are no literature reports and patent publications on th

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gel composition for eyes and preparation method thereof
  • Gel composition for eyes and preparation method thereof
  • Gel composition for eyes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

[0037] Preparation method:

[0038] (1) Weigh the prescribed amount of Carbomer 940 and sprinkle it on the water surface of 1000 ml of water for injection for 3 times, leave it overnight to make it fully swell and dissolve, and filter it with a 200-mesh sieve cloth as solution I.

[0039] (2) Weigh the prescribed amount of chondroitin sulfate, taurine, benzalkonium chloride, and glycerin and dissolve them in 2000 ml of water for injection in sequence, and filter with a 0.22 μm microporous membrane to obtain solution II.

[0040] (3) Solution II was slowly added to solution I, and ground while adding to make it fully mixed, and then 10% sodium hydroxide solution was added dropwise to form a gel, and the pH value was adjusted to about 6.5.

[0041] (4) Add water for injection to 4000g, grind well, and defoam.

[0042] (5) Sterilize with circulating steam at 100°C for 30 minutes, let cool and fill (4g / bottle).

Embodiment 8-14

[0044] method

[0045] (1) Weigh the prescribed amount of Carbomer 934 and sprinkle it on the water surface of 1000 ml of water for injection for 3 times, place it overnight to make it fully swell and dissolve, and filter it with a 200-mesh sieve cloth as solution I.

[0046] (2) Weigh the prescribed amount of chondroitin sulfate, taurine, benzalkonium chloride, and glycerin and dissolve them in 2000 ml of water for injection in sequence, and filter with a 0.22 μm microporous membrane to obtain solution II.

[0047] (3) Solution II was slowly added to solution I, and ground while adding to make it fully mixed, and then 10% sodium hydroxide solution was added dropwise to form a gel, and the pH value was adjusted to about 6.5.

[0048] (4) Add water for injection to 4000g, grind well, and defoam.

[0049] (5) Sterilize with circulating steam at 100°C for 30 minutes, let cool and then fill.

Embodiment 15-21

[0051] Preparation method:

[0052] (1) Weigh the prescribed amount of Carbomer 941 and sprinkle it on the water surface of 1000 ml of water for injection for 5 times, leave it overnight to make it fully swell and dissolve, and filter it with a 200-mesh sieve cloth as solution I.

[0053] (2) Weigh the prescribed amount of chondroitin sulfate, taurine, benzalkonium chloride, and glycerin and dissolve them in 2000 ml of water for injection in sequence, and filter with a 0.22 μm microporous membrane to obtain solution II.

[0054] (3) Solution II was slowly added to solution I, and ground while adding to make it fully mixed, and then 10% sodium hydroxide solution was added dropwise to form a gel, and the pH value was adjusted to about 6.5.

[0055] (4) Add water for injection to 4000g, grind well, and defoam.

[0056] (5) Sterilize with circulating steam at 100°C for 30 minutes, let cool and then fill.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses an ophthalmic gel composition and a preparing method thereof, wherein the ophthalmic gel composition according to the invention is composed of chondroitin sulfate, taurine and medical supplementary material. The invention successfully develops the ophthalmic gel composition which is currently hard through combining the prior clinical ophthalmic medicine. The ophthalmic gel composition has excellent fluidity and dispersibility and has beneficial contribution for increasing curative effect. Furthermore the prior animal experiment shows that the ophthalmic gel composition of the invention has excellent safety and provides a powerful guarantee for the further product commercialization.

Description

【Technical field】 [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an ophthalmic gel composition and a preparation method thereof. 【Background technique】 [0002] Chondroitin sulfate refers to a mucopolysaccharide made from the cartilage of healthy animals (cattle, pigs, birds and other food animals). Chondroitin sulfate is mainly composed of polymers of N-acetylchondrosamine and D-glucoromic acid, and its sodium is combined with sulfate. The five-carbon sugars in the chain are alternately combined into polymers through β-1,4, and β-2,3. The main mucopolysaccharides include chondroitin sulfate A (CSA) and chondroitin sulfate C (CSC). The sulfate group of CSA type is on the 4th carbon of N-acetylchondrosamine, and the sulfate group of CSC type is on the 6th carbon of N-acetylchondrosamine. Chondroitin sulfate is a kind of mucopolysaccharide, which is used as the raw material of health care medicine and beauty ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/00A61K47/32A61K31/737A61P27/02A61K31/185
Inventor 杨文龙
Owner 杨文龙
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap