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Tramadol gel for nose as well as preparation method and application thereof

A gel and tramadol technology, applied in the field of pharmaceutical preparations, can solve the problems of slow onset of oral preparations, large adverse reactions of injections, and inability to administer autonomously.

Inactive Publication Date: 2012-05-23
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, each preparation has its limitations. The adverse reactions of injections are large, and it cannot be administered independently; the oral preparations have slow onset of action.

Method used

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  • Tramadol gel for nose as well as preparation method and application thereof
  • Tramadol gel for nose as well as preparation method and application thereof
  • Tramadol gel for nose as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0049] Preparation method: take 500ml of deionized water, weigh the prescribed amount of tramadol hydrochloride, the corresponding polymer material as the gel matrix, preservative and pH regulator, stir evenly, and after each component is fully swollen / dissolved, Add deionized water quantitatively to 1000ml, that is.

[0050] The preparation can prolong the residence time of the drug in the nasal cavity, reduce the elimination of the drug by nasal cilia, and increase the nasal cavity absorption of the drug.

Embodiment 1

[0052] Prepare tramadol hydrochloride nasal gel according to the following proportions:

[0053] tramadol hydrochloride

Embodiment 2

[0055] Prepare tramadol hydrochloride nasal gel according to the following proportions:

[0056] tramadol hydrochloride

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PUM

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Abstract

The invention provides a nasal gel of tramandol having tramandol or pharmaceutically acceptable salt; gel substrate; and pharmaceutically acceptable accessories. The tramadol nasal gel provided by the invention is capable of improving amount of medicament in central nervous system which quick action, long lasting time, low toxicity and easy use.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a nasal gel of tramadol, which is suitable for treating various moderate and severe pains. Background technique [0002] Pain brings physical and psychological torture to patients and destroys their quality of life. About 30% of adults suffer from pain, and there are at least 100 million pain patients in our country. Based on different pathogenesis, pain has different manifestations in various diseases. The occurrence and duration of pain are different in different patients, and the analgesic methods required for individual special types of pain are also very different. The best treatment for pain is to be able to administer medicines autonomously when pain occurs, to take effect quickly, and to last for a certain period of time. [0003] Tramadol (Tramadol) is a central analgesic drug, the chemical name is (±)-E-2-[(dimethylamino)methyl]-1-(3-methylaminophenyl)-cyclohe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61K9/00A61K47/32A61K47/36A61K47/38A61P25/04
Inventor 陶涛赵雁
Owner SHANGHAI INST OF PHARMA IND CO LTD