Use of tetrahydropyridines in preparing medicine for treating arthritis

A technology for tetrahydropyrimidine and arthritis, which is applied in the application field of tetrahydropyrimidine in the preparation of drugs for treating arthritis, and can solve the problems such as the research and report on tetrahydropyrimidine arthritis, joint degeneration, and increased infection that have not yet been seen.

Inactive Publication Date: 2009-07-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it temporarily relieves pain, multiple intra-articular injections of steroids can degenerate the joint, resulting in "corticosteroid arthropathy"
The hormone also inhibi...

Method used

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  • Use of tetrahydropyridines in preparing medicine for treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Intra-articular injection containing ectoine

[0018] Main component Ectrahydropyrimidine 2.0g

[0019] Sodium Hyaluronate 1.0g

[0020] Sulfasalazine 3.0g

[0021] Dissolve the prescribed amount of sulfasalazine in water for injection, mix and grind ectoine and sodium hyaluronate according to the prescribed amount, gradually add the above solution, adjust the pH to 6.0-8.5 with phosphate buffer, add sterile water for injection To 1000ml, adjust the osmotic pressure to 220-336 milliosm / liter. After autoclaving and subpackaging, the liquid preparation for intra-articular injection containing ectoine is obtained.

Embodiment 2

[0022] Embodiment 2: Intra-articular injection containing ectoine

[0023] Main component Ectrahydropyrimidine 3.0g

[0024] Prednisolone 1.0g

[0025] Chondroitin Sulfate 4.0g

[0026] Neostigmine 1.0g

[0027] Dissolve the prescribed amount of chondroitin sulfate in ethanol, mix and grind ectoine and prednisolone according to the prescribed amount, gradually add neostigmine and mix, dissolve with 70°C water for injection, then mix the two solutions and filter. Adjust the pH to 5.0-8.0 with phosphate buffer, add sterilized water for injection to 1000ml, and adjust the osmotic pressure to 220-336 milliosm / liter. After autoclaving and subpackaging, the liquid preparation for intra-articular injection containing ectoine is obtained.

Embodiment 3

[0028] Embodiment 3: Intra-articular injection containing ectoine

[0029] Main component Ectrahydropyrimidine 3.0g

[0030] Chitosan 2.0g

[0031] Methotrexate 2.0g

[0032] Take carbomer as the base, take 14.0g of carbomer and add water to swell, adjust the pH value to 6.0-8.0 with phosphate buffer solution, take another 2.0g of chitosan and add 80°C water for injection to swell, add the prescribed amount of tetrahydro pyrimidine, then mix the two liquids while they are hot, stir evenly, add sterilized water for injection to 1000ml, heat-press sterilize, and subpackage to obtain the intra-articular injection preparation containing ectoine.

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Abstract

The invention discloses novel application for Ectoine, namely application of the Ectoine in preparing medicines of treating arthritis. The effective dosage range of the Ectoine is 0.1 to 100 mg/kg of body weight, preferably 8 to 50mg/kg of the body weight. When in use, the Ectoine can be used independently, or can be combined with other medicines for use. The Ectoine has high water solubility and osmoregulation function; and the experiment proves that the Ectoine can stabilize joint tissue and joint synovia, improve the adaptability of the joint tissue to environment change and improve the curative effect of other components in a preparation except for the Ectoine, so the Ectoine can be used for treating the arthritis.

Description

technical field [0001] The invention relates to the application of ectoine in the preparation of medicine for treating arthritis. Background technique [0002] Arthritis is one of the common diseases of the elderly. Arthritis is a common chronic disease. The most common types are osteoarthritis and rheumatoid arthritis. It is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. keep growing. According to statistics, half of the people over the age of 50 in my country suffer from osteoarthritis; 90% of the women and 80% of the men over the age of 65 suffer from osteoarthritis. The prevalence of rheumatoid arthritis in my country is 0.34% to 0.36%. Its pathogenesis is not yet fully understood, and the therapeutic effect of the drug can be better exerted by directly acting on the diseased site through intra-articular administration. At present, there are mainly two active ingredients of intra-articular injection ...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61P19/02A61K9/00
Inventor 厉保秋
Owner SHANDONG UNIV
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