A pharmaceutical composition with the effect of treating rhinitis and its preparation method

A composition and medicine technology, applied to a pharmaceutical composition for sinusitis and allergic rhinitis and its preparation, has the field of treating rhinitis, and can solve problems such as drug resistance and the like

Active Publication Date: 2011-12-07
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, most of the existing nasal external preparations contain ephedra, and long-term use of ephedra will cause drug resistance

Method used

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  • A pharmaceutical composition with the effect of treating rhinitis and its preparation method
  • A pharmaceutical composition with the effect of treating rhinitis and its preparation method
  • A pharmaceutical composition with the effect of treating rhinitis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0199] Embodiment 1: pharmaceutical composition nasal cavity spray of the present invention

[0200] Woody Fragrance 50kg Sour Vine Fruit 30kg

[0201] Benzoin 20kg Butacea 30kg;

[0202] Take the raw material drug, mix, extract with 10 times by weight, 8 times by weight, and 6 times by weight of water for 2 hours, 1 hour and 0.5 hours respectively, filter, take the filtrate and concentrate it to a concentrated solution with a relative density of 1.01-1.10, and use slow and fast stirring Methods Add ethanol to the concentrated solution to make the alcohol content reach 60%, refrigerate for 24 hours, filter, and recover the ethanol; dilute the filtrate with 100kg of distilled water, add osmotic pressure regulator, pH regulator, preservative, penetration enhancer, pour into a spray bottle to make a nasal spray.

Embodiment 2

[0203] Embodiment 2: pharmaceutical composition nasal cavity spray of the present invention

[0204] Woody Fragrance 45kg Sour Vine Fruit 15kg

[0205] Benzoin 5kg Buttermilk 35kg

[0206] Goose does not eat grass 28kg Myrobalan 5kg

[0207] Licorice 3kg;

[0208] Take the raw material drug, mix, extract with 10 times by weight, 8 times by weight, and 6 times by weight of water for 2h, 1h and 0.5h respectively, filter, concentrate the filtrate to 1:1-1:2 (ml:g) and then oversize Pore ​​adsorption resin, washed with water, eluted with 90% ethanol, collected eluate, evaporated to dryness, to obtain the active component, dilute the active component with 150kg of distilled water, then add osmotic pressure regulator, pH regulator, preservative , a penetration enhancer, poured into a spray bottle to prepare a nasal cavity spray.

Embodiment 3

[0209] Embodiment 3: pharmaceutical composition nasal cavity spray of the present invention

[0210] Woody Fragrance 20kg Sour Vine Fruit 35kg

[0211] Benzoin 15kg Buttermilk 15kg

[0212] Goose does not eat grass 3kg Myrobalan 45kg;

[0213] Take the raw materials, mix them, and extract them with 10, 8, and 6 weight times of 80% ethanol for 2 hours, 1 hour, and 0.5 hours, and let stand and filter; recover the ethanol, and refrigerate and filter; concentrate the filtrate to 1 : 1-1: 2 (ml: g) after passing through the macroporous adsorption resin, washing with water, eluting with 90% ethanol, collecting the eluate, evaporating to dryness, obtaining the active component, diluting the active component with 100kg distilled water , then add conventional auxiliary materials, and pour into a spray bottle to prepare a nasal cavity spray.

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Abstract

The invention discloses a pharmaceutical composition for treating rhinitis, sinusitis and allergic rhinitis and a preparation method thereof. , myrobalan or licorice. The preparation method uses methods such as alcohol extraction and water precipitation or water extraction and alcohol precipitation to prepare clinically accepted conventional preparations according to conventional processes, including but not limited to sprays, powder mist, gels, granules and other dosage forms. A large number of experiments show that the pharmaceutical composition of the invention has better effects on treating rhinitis, sinusitis and allergic rhinitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition capable of treating rhinitis, in particular to a pharmaceutical composition capable of treating rhinitis, sinusitis and allergic rhinitis and a preparation method thereof. Background technique [0002] Rhinitis is the most common disease in clinical rhinology. The pathogenesis is complex and the clinical symptoms are different. When the physiological function of the nasal cavity is affected, breathing disorders will occur, causing blood oxygen concentration to decrease, and affecting the function and metabolism of other tissues and organs. , and some such as headache, dizziness, memory loss, chest pain, chest tightness, lethargy, etc., and even serious complications such as emphysema, pulmonary heart disease, and asthma. When rhinitis is not treated in time and affects the olfactory mucosa, olfactory disturbance will occur, resulting in the inability to smell odors such as fragrance and odor. What'...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/285A61K36/484A61K9/00A61K9/12A61P11/02
Inventor 白玛卓玛朱建英
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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