Livestock cefquinome colon-targeted pills and preparation method thereof

Abstract

The invention belongs to the technical field of veterinary drugs and relates to livestock cefquinome colon-targeted pills. The livestock cefquinome colon-targeted pills comprise cefquinome serving as a main drug, and empty pellets are covered with a drug layer made of the cefquinome, 8 percent of a block layer made of cetanol, 2 percent of a time lag layer made of HPMC, and 15 percent of a pH sensitive film made of eudragit S100 respectively to form the livestock cefquinome colon-targeted pills. The livestock cefquinome colon-targeted pellets combining time lag and pH sensitivity can release drug at fixed positions of the colons of livestock, greatly improve the treatment effect on local infection and general infection, have low toxicity and little residue in edible animal tissues, and can be widely applied to clinic treatment of the livestock.

Description

technical field

[0001] The invention belongs to the technical field of veterinary medicine, and relates to a cefquinome colon-targeted pill for treating sensitive bacterial infectious diseases of livestock and a preparation method thereof. Background technique

[0002] With the continuous improvement of the scale and intensification of livestock breeding, various problems in breeding also follow. Some diseases caused by bacteria and mycoplasma often occur in domestic animals. For the above-mentioned situation, the current treatment method for this type of disease is mainly to control this type of disease with antibiotics. In terms of human medicine, there is a colon-targeted drug delivery system (OCDDS), which is a targeted preparation that releases drugs in the colon. Oral colon-targeted drug delivery system is a research hotspot recently. It is a new preparation for localized drug release in the colon through oral administration to achieve local or systemic treatment. Th...

Examples

Embodiment 1

[0039] Embodiment 1: the preparation method of cefquinome colon targeting pill

[0040] 1. Drugs, excipients and reagents

[0041] Cefquinome raw material drug, Eudragit S100, triethyl citrate, blank pellets 40 mesh, HPMC 15MPa.S, 10MPa.S, 5MPa.S, 95% ethanol.

[0042] 2. Instruments and equipment

[0043] EPL-1 fluidized bed, 78HW-1 magnetic stirrer, J-11 stirrer

[0044] 3. Preparation method

[0045] 1. Place 900 g of blank pellets in a fluidized bed, and coat the drug layer, retardation layer, time lag layer and pH-sensitive film in sequence according to the following methods and processes.

[0046] (1) Coating of the main drug

[0047]Preparation of coating solution: 100 g of cefquinome was dissolved in 1000 ml of 50% ethanol.

[0048] Coating conditions:

[0049] Material temperature: 40°C Air outlet temperature: 40°C Liquid supply hose inner diameter: 2mm

[0050] Air inlet temperature: 48°C Liquid supply speed: 20r / min Spray gun diameter: 1.2mm

[0051] Induced...

Embodiment 2

[0071] Example 2: The prepared cefquinome colon-targeted pills are mainly used to treat cow mastitis caused by Escherichia coli, and porcine respiratory diseases caused by Pasteurella multocida or Actinobacillus pleuropneumoniae. The method of administration is mixing material administration, once a day for 2 consecutive days at 1 mg / kg body weight for cattle; 2-3 mg / kg body weight once a day for 3 consecutive days for pigs. Animals allergic to b-lactam antibiotics are forbidden to use this product.

technical field

[0001] The invention belongs to the technical field of veterinary medicine, and relates to a cefquinome colon-targeted pill for treating sensitive bacterial infectious diseases of livestock and a preparation method thereof. Background technique

[0002] With the continuous improvement of the scale and intensification of livestock breeding, various problems in breeding also follow. Some diseases caused by bacteria and mycoplasma often occur in domestic animals. For the above-mentioned situation, the current treatment method for this type of disease is mainly to control this type of disease with antibiotics. In terms of human medicine, there is a colon-targeted drug delivery system (OCDDS), which is a targeted preparation that releases drugs in the colon. Oral colon-targeted drug delivery system is a research hotspot recently. It is a new preparation for localized drug release in the colon through oral administration to achieve local or systemic treatment. Th...

Examples

Embodiment 1

[0039] Embodiment 1: the preparation method of cefquinome colon targeting pill

[0040] 1. Drugs, excipients and reagents

[0041] Cefquinome raw material drug, Eudragit S100, triethyl citrate, blank pellets 40 mesh, HPMC 15MPa.S, 10MPa.S, 5MPa.S, 95% ethanol.

[0042] 2. Instruments and equipment

[0043] EPL-1 fluidized bed, 78HW-1 magnetic stirrer, J-11 stirrer

[0044] 3. Preparation method

[0045] 1. Place 900 g of blank pellets in a fluidized bed, and coat the drug layer, retardation layer, time lag layer and pH-sensitive film in sequence according to the following methods and processes.

[0046] (1) Coating of the main drug

[0047]Preparation of coating solution: 100 g of cefquinome was dissolved in 1000 ml of 50% ethanol.

[0048] Coating conditions:

[0049] Material temperature: 40°C Air outlet temperature: 40°C Liquid supply hose inner diameter: 2mm

[0050] Air inlet temperature: 48°C Liquid supply speed: 20r / min Spray gun diameter: 1.2mm

[0051] Induced...

Embodiment 2

[0071] Example 2: The prepared cefquinome colon-targeted pills are mainly used to treat cow mastitis caused by Escherichia coli, and porcine respiratory diseases caused by Pasteurella multocida or Actinobacillus pleuropneumoniae. The method of administration is mixing material administration, once a day for 2 consecutive days at 1 mg / kg body weight for cattle; 2-3 mg / kg body weight once a day for 3 consecutive days for pigs. Animals allergic to b-lactam antibiotics are forbidden to use this product.