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Livestock cefquinome solution containing hexacyclic water

A technology of cefquinoxime and hexacyclic water, applied in the field of veterinary medicine, can solve the problems of short duration of peak blood drug concentration, easy to cause stress in livestock, poor bioavailability, etc., and achieves good bioavailability, improved curative effect, and drug The effect of increased release rate and release amount

Inactive Publication Date: 2009-09-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, in veterinary preparations, the water preparations commonly used for antibacterial drugs are mainly injections, and ordinary purified water is often used in the production process. This preparation has slow release speed, short time for the peak blood concentration, and poor bioavailability. , It is easy to cause livestock stress and other problems after use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: a. Purified water (i.e., pure water) is selected as raw water. Generally, commercially available purified water with conductivity less than 20μs / em is sufficient. After standing for several hours, it will slowly freeze, and the cooling rate will be 2-5°C / h. The minimum freezing temperature reaches -30~-50℃, so that the water is fully crystallized, and then thawed. The thawing process is carried out below 10℃. The melted water is collected and stored in a temperature environment of 4-10℃ in time, that is Get six rings of water;

[0023] b. Take 20 ml of purified water and add an appropriate amount of Cefquinome and stir until all is dissolved.

[0024] c. Add purified water to the full amount of 40 ml, and adjust the pH value to 3.0-5.0 with 40% sulfuric acid.

[0025] d. Filter.

[0026] e. Semi-finished products are submitted for inspection and determination

[0027] f. Qualified products are filled with a filling amount of 100±1%.

[0028] g. Check the tightne...

Embodiment 2

[0030] Example 2: The drug of the present invention is an antibacterial drug, which is mainly used to treat cow mastitis caused by Escherichia coli, and swine respiratory diseases caused by Pasteurella multocida or Actinobacillus pleuropneumoniae. The method of administration is mixed material administration, with 1 mg / kg body weight of cattle once a day for 2 days; 2 to 3 mg / kg body weight of pigs once a day for 3 days. Animals allergic to b-lactam antibiotics are prohibited from using this product.

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PUM

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Abstract

The invention belongs to the technical field of veterinary drugs and relates to a livestock antibacterial drug of broad spectrum antibiotic solution prepared by using cefquinome as a raw material. The cefquinome solution uses hexacyclic water as a carrier. The hexacyclic water prepared by refrigeration is filled in the cefquinome solution, so that the volume of water clusters is reduced and correspondingly the viscosity, surface tension and the like of water are reduced to reduce the diffusion resistance of the cefquinome and to promote drug release. The speed and amount of drug release of the cefquinome solution are improved. The hexacyclic water has high cellular affinity. The livestock cefquinome solution containing hexacyclic water is used for treating sensitive bacteria infection of livestock, obviously improves the treatment effect of the drug, and quickly promotes the restoration from diseases.

Description

Technical field [0001] The invention belongs to the technical field of veterinary drugs, and relates to preparing a broad-spectrum antibacterial drug using cefquinoxime as a raw material, which is used as a veterinary drug for bacterial infection of livestock. Background technique [0002] Water is the most important component in all organisms. The water content of organisms is generally above 60%. Except for dry products, the water content of food is between 65% and 90%. It can be said that water plays a role in our lives. Plays a very important role. Water has many special properties and has attracted people's attention in recent years. For example, in the magazine "Jiangxi Chemical Industry", "The Magical Water of Life", page 34 of the fourth issue of 1997, the water with the structure of six water molecules, the so-called "six-ring water", has the function of promoting health. [0003] The "Six-ring structure of water and its effect on thermal denaturation of lysozyme" includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K31/546A61P31/00
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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