Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist

A thrombin receptor and antagonist technology, which is applied in the field of fast-disintegrating orally administered pharmaceutical compositions, and can solve the problem that patients cannot swallow solid preparations and the like
CN101541302AInactive Publication Date: 2009-09-23SCHERING AG
15 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SCHERING AG
Publication Date
2009-09-23
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

Disclosed is a lyophilized rapidly disintegrating solid dosage form, one embodiment of which comprises a thrombin receptor antagonist such as, formula (A), or a pharmaceutically acceptable salt or hydrate thereof, a polymer such as gelatin, and a matrix forming agent such as mannitol. Systems for effectively buffering the pre-lyophilized suspension are taught, along with methods of treating patients at risk for acute coronary syndrome by administering such a rapidly disintegrating solid dosage form.
Need to check novelty before this filing date? Find Prior Art

Description

field of invention

[0001] The present invention relates to rapidly disintegrating orally administrable pharmaceutical compositions containing thrombin receptor antagonists and their use in the treatment of patients at risk of acute coronary syndrome. Background of the invention

[0002] Thrombin is known to have various activities in different cell types, and thrombin receptors are known to be present in such cell types as human platelets, vascular smooth muscle cells, endothelial cells and fibroblasts. Thrombin receptor antagonists ("TRA"), also known as protease-activated receptor (PAR) antagonists, are believed to be useful in the treatment of thrombosis, inflammatory diseases, atherosclerotic and fibroproliferative diseases as well as thrombin and its receptors. Useful in other conditions in which the body plays a role in pathology. Acute coronary syndrome is one such condition.

[0003] Acute Coronary Syndrome ("ACS") is an umbrella term used to include any clinical c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More