Compound toltrazuril solution and method for preparing same

A technology of compound toltrazuril and toltrazuril, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, and devices for making medicines into special physical or ingestible forms, which can solve the problem of unsatisfactory effects and animal organisms. Reduced feed intake, troublesome use, etc.

Inactive Publication Date: 2009-10-07
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many kinds of drugs for the treatment of coccidiosis, but there are also many disadvantages: the use of some drugs leads to adverse reactions such as decreased feed intake in animals, and the emergence of drug resistance caused by repeated use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the composition in every 100ml solution is: toltrazuril 2.5g, nitazoxanide 3g, ethanol 7ml, polyethylene glycol-400 33ml, edetate disodium 0.2g, sodium sulfite 0.2g, Triethanolamine 1.8ml, the remainder propylene glycol. The consumption of triethanolamine is based on adjusting the pH value of the solution to be 9.0.

[0019] The preparation method of compound toltrazuril solution, first mix 30ml of propylene glycol and 33ml of polyethylene glycol-400 evenly, heat to 70°C, add 0.2g of sodium sulfite and 0.2g of disodium edetate and stir to dissolve completely, Add 1.8ml of triethanolamine to adjust the pH value of the solution to 9.0; then, add 2.5g of toltrazuril and 3g of nitazoxanide respectively, and stir to dissolve completely; after standing at room temperature, add 7ml of ethanol and stir to mix evenly, and dilute to volume with propylene glycol to 100mL, filtered; after passing the inspection, canned, sealed, and sterilized.

Embodiment 2

[0020] Embodiment 2: The composition in every 100ml solution is: toltrazuril 3.5g, nitazoxanide 6g, ethanol 9ml, polyethylene glycol-400 25ml, disodium edetate 0.3g, sodium sulfite 0.4g, three Ethanolamine 2.3ml, the rest of the propylene glycol. The consumption of triethanolamine is based on adjusting the pH value of the solution to be 9.5.

[0021] The preparation method of the compound toltrazuril solution, first mix 35ml of propylene glycol and 25ml of polyethylene glycol-400 evenly, heat to 75°C, add 0.4g of sodium sulfite and 0.3g of disodium edetate and stir to dissolve completely, Add 2.3ml of triethanolamine to adjust the pH value of the solution to 9.5; then, add 3.5g of toltrazuril and 6g of nitazoxanide respectively, and stir to dissolve completely; after standing at room temperature, add 9ml of ethanol and stir to mix evenly, and dilute to volume with propylene glycol to 100mL, filtered; after passing the inspection, canned, sealed, and sterilized.

Embodiment 3

[0022] Embodiment 3: the composition in every 100ml solution is: Toltrazuril 5g, nitazoxanide 8g, ethanol 10ml, polyethylene glycol-400 20ml, disodium edetate 0.4g, sodium sulfite 0.5g, triethanolamine 1.9ml, the balance of propylene glycol. The consumption of triethanolamine is based on adjusting the pH value of the solution to be 10.0.

[0023] The preparation method of compound toltrazuril solution, first mix 40ml propylene glycol and 20ml polyethylene glycol-400 evenly, heat to 80°C, add 0.5g sodium sulfite and 0.4g disodium edetate and stir to dissolve completely, Add 1.9ml of triethanolamine to adjust the pH value of the solution to 10.0; then, add 5g of toltrazuril and 8g of nitazoxanide respectively, and stir to dissolve completely; after standing at room temperature, add 10ml of ethanol and stir to mix evenly, and dilute with propylene glycol to 100mL, filtered; after passing the inspection, canned, sealed and sterilized.

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PUM

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Abstract

The present invention provides a compound toltrazuril solution. Each 100 ml solution contains medicinal ingredient as follows: toltrazuril 2.5-5 g, nitazoxanide 3-8 g. The compound toltrazuril solution has advantages of low cost, better coccidiostat effect, wide antigen insert, low dose and no-easy drug-tolerance, the compound toltrazuril solution also can be added into drinking water for animal which is more convenient without adding and stirring to feed stuff.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a compound toltrazuril solution and a preparation method of the solution. Background technique [0002] Chicken coccidiosis is a protozoan disease of chickens caused by Eimeria coccidiosis, which is one of the common and serious diseases in modern poultry industry. Coccidiosis often causes chicken morbidity, and the mortality rate is as high as 80%. The growth of the recovered chicken is seriously delayed, the resistance is reduced, and it is easy to suffer from other diseases. Adult chickens seldom get sick, but they can become carriers, and their physique and egg-laying ability can be affected, which often brings huge economic losses to the chicken industry. According to statistics, coccidiosis causes economic losses of 120 million U.S. dollars to the poultry industry all over the world every year. [0003] At present, there are many kinds of drugs for the treatment of coccid...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61K31/426A61K9/08A61J3/00A61P33/02
Inventor 胡功政李凌峰
Owner HENAN SOAR VETERINARY PHARMA
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