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Application of super maduramycin in the preparation of drugs for preventing and treating poultry coccidiosis

A technology for livestock and poultry coccidiosis and maduramycin, applied in the field of livestock and poultry medicines, can solve problems such as increased technical difficulty, restrictions on the use and application range of maduramycin, chicken poisoning, etc., and achieve the effect of expanding the scope of application

Active Publication Date: 2016-04-27
河南孟成生物药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although maduramycin has the advantages of remarkable application effect, outstanding effect of preventing and treating coccidiosis, and small dosage, it also has the following defects: 1) The target range of use is narrow, and it is only used for the prevention and treatment of chicken coccidiosis, not for chicken coccidiosis. The use of most livestock and poultry such as ducks, pigs, cattle, sheep, etc.
2) The measurement range of product usage is small
When using it, it is necessary to accurately control the addition of medicines. If the dose is too low, a good anti-coccidial effect will not be achieved; but if the dose exceeds 5ppm, the chickens will be poisoned and cause a large number of deaths.
In this way, when the above-mentioned products are used, the technical difficulty of accurate addition and feed mixing in the feed increases, and the difficulty of mixing is increased, resulting in that high-quality products cannot be used effectively and rationally.
Because it is not easy to evenly and accurately mix 5ppm of medicine in the feed, especially for some small-scale feed mills, which limits the use and application range of the United States and domestic maduramycin

Method used

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  • Application of super maduramycin in the preparation of drugs for preventing and treating poultry coccidiosis
  • Application of super maduramycin in the preparation of drugs for preventing and treating poultry coccidiosis
  • Application of super maduramycin in the preparation of drugs for preventing and treating poultry coccidiosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Super Maduramycin, its structural formula is as follows:

[0026] .

[0027] The synthetic method of above-mentioned super maduramycin, it comprises the following steps:

[0028] Accurately weigh 50g of maduramycin and 80ml of glacial acetic acid into a 1000ml three-neck flask, mix and stir for 2min at room temperature, and slowly add 116ml of acetic anhydride at a temperature of 5°C within 5min. Another 0.5ml of MSA was diluted with 8ml of glacial acetic acid and added to the three-necked flask within 10min. The temperature was raised to 60°C and the reaction was stirred for 50 minutes. After the reaction is over, pour the product into deionized water while stirring (the volume ratio of product to deionized water is 1:10), filter, wash the filter cake with deionized water to remove residual impurities and MSA, and then vacuum at 60°C After drying to constant weight, 51.3 g of white super maduramycin crystals were obtained.

Embodiment 2

[0030] Super Maduramycin, its structural formula is as follows:

[0031] .

[0032] The synthetic method of above-mentioned super maduramycin, it comprises the following steps:

[0033] Accurately weigh 50g of maduramycin and 80ml of glacial acetic acid into a 1000ml three-neck flask, mix and stir for 2min at room temperature, and slowly add 116ml of acetic anhydride at a temperature of 5°C within 5min. Another 0.5ml of MSA was diluted with 8ml of glacial acetic acid and added to the three-necked flask within 10min. The temperature was raised to 65°C and the reaction was stirred for 60 minutes. After the reaction, the product was poured into deionized water while stirring (the volume ratio of product to deionized water was 1:10), filtered, the filter cake was washed with deionized water, and then vacuum-dried at 60°C to constant weight to obtain 53.6g white super maduramycin crystals.

Embodiment 3

[0035] Super Maduramycin, its structural formula is as follows:

[0036] .

[0037] The synthetic method of above-mentioned super maduramycin, it comprises the following steps:

[0038] Accurately weigh 50g of maduramycin and 80ml of glacial acetic acid into a 1000ml three-neck flask, mix and stir for 2min at room temperature, and slowly add 116ml of acetic anhydride at a temperature of 5°C within 5min. Another 1ml of MSA was diluted with 8ml of glacial acetic acid and added to the three-necked flask within 10min. The temperature was raised to 65°C and the reaction was stirred for 60 minutes. After the reaction, the product was poured into deionized water while stirring (the volume ratio of product to deionized water was 1:10), filtered, the filter cake was washed with deionized water, and then vacuum-dried at 60°C to constant weight to obtain 52.4g white super maduramycin crystals.

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PUM

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Abstract

The invention belongs to the technical field of drugs for livestock and poultry, and particularly relates to a super maduramicin of which the structural formula is shown below. The invention also discloses a synthesis method of the super maduramicin and application of the super maduramicin in preparation of drugs for controlling coccidiosis of livestock and poultry. The super maduramicin has favorable coccidiosis resistance effect, and even excess can not cause poisoning of livestock and poultry; and the super maduramicin has a wide application range, and can be used for controlling coccidiosis of various livestock and poultry such as chickens, ducks, quails, pigs, cows, sheep, horses or the like.

Description

technical field [0001] The invention belongs to the technical field of medicines for livestock and poultry, and in particular relates to a super maduramycin, a synthesis method and its application in the preparation of medicines for preventing and treating coccidiosis of livestock and poultry. Background technique [0002] Maduramycin (Ammonium), the structural formula is as follows: it is a secondary metabolite produced by Actinomyces madurai, and it is the most potent ion-carrying polyether antibiotic found in the world. Anticoccidial antibiotics. Maduramycin was first developed and produced by the U.S. cyanamide company under the trade name "CYGRO". It entered the veterinary drug market in my country in 1990. All units that have used and tested it are satisfied with the anti-coccidial effect of "CYGRO". . However, due to the high price of imported drugs, the production cost of feed is increased when using them. At present, there are also manufacturers producing maduramy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P33/02C07H17/04C07H1/00
Inventor 任发强梁建平陶蕾孟军虎徐灵芝赵凤舞张贺义贾忠
Owner 河南孟成生物药业股份有限公司
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