Inhibition of degradation of extracellular matrix

An extracellular matrix and cell technology, applied in the field of heparanase inhibitors, can solve problems such as islet function loss
CN101588808AInactive Publication Date: 2009-11-25AUSTRALIEN NAT UNIV
1 Cites 6 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AUSTRALIEN NAT UNIV
Publication Date
2009-11-25
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

This application realtes to a method of inhibiting the degradation of an extracellular matrix associated with islet beta cells, the method comprising contacting the extracellular matrix with an effective amount of a heparanase inhibitor.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] Cross references to related patent applications

[0002] This application claims priority based on Australian Provisional Patent Application No. 2006905854 filed on October 20, 2006, which is hereby incorporated by reference in its entirety. technical field

[0003] The present invention relates to the use of heparanase inhibitors in the treatment of disorders associated with degradation of the extracellular matrix, such as insulitis or autoimmune type 1 diabetes. In particular, the present invention relates to improvements in the efficacy of transplantation for the treatment of insulitis or type 1 diabetes. Background technique

[0004] Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing beta cells of the pancreatic islets are destroyed. In humans, the disease has a dramatic impact on lifestyle, and imperfect control of hyperglycemia by exogenous insulin therapy inevitably leads to microvascular disease. This complication may eventually le...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More