Medicinal composition of cefotetan disodium
A technology of cefotetan disodium and composition, which is applied in the field of pharmaceutical compositions of cefotetan disodium, can solve the problems of unqualified products, inability to use, process difficulties and the like, and achieves the advantages of enhanced stability and improved stability. Effect
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Embodiment 1
[0022] In this example, the specific content of each component of the pharmaceutical composition of cefotetan disodium is shown in Table 1 below.
[0023] The composition component one of table 1 cefotetan disodium
[0024] components
dose (mg)
Per cent of the total mass of the composition
Ratio (%)
500
50
glucose
500
50
[0025] According to the above components, the 500mg / bottle of cefotetan disodium for injection was prepared by freeze-drying technology. The specific process is: dissolving cefotetan disodium in the aqueous solution of glucose, adding activated carbon for needles and stirring, and filtering to remove the activated carbon, then performing sterile filtration, filling, and then placing it in a freeze dryer to freeze-dry to make a finished product .
[0026] After dosing according to the prescription, filter the filtrate to detect related substances, and compare it wit...
Embodiment 2
[0028] In this example, the specific content of each component of the pharmaceutical composition of cefotetan disodium is shown in Table 2 below.
[0029] The composition component two of table 2 cefotetan disodium
[0030] components
dose (mg)
Per cent of the total mass of the composition
Ratio (%)
500
60
[0031] glucose
333
40
[0032] According to the above components, 500 mg / bottle of cefotetan disodium for injection was obtained by using freeze-drying technology. The specific process is: dissolving cefotetan disodium in the aqueous solution of glucose, adding activated carbon for needles and stirring, and filtering to remove the activated carbon, then performing sterile filtration, filling, and then placing it in a freeze dryer to freeze-dry to make a finished product .
[0033] After dosing according to the prescription, filter the filtrate to detect related substanc...
Embodiment 3
[0035] In this example, the specific content of each component of the pharmaceutical composition of cefotetan disodium is shown in Table 3 below.
[0036] Table 3 Composition Component Three of Cefotetan Disodium
[0037] components
dose (mg)
Per cent of the total mass of the composition
Ratio (%)
Cefotetan Disodium
500
65
glucose
233
35
[0038] According to the above components, 500 mg / bottle of cefotetan disodium for injection was obtained by using freeze-drying technology. The specific process is: dissolving cefotetan disodium in the aqueous solution of glucose, adding activated carbon for needles and stirring, and filtering to remove the activated carbon, then performing sterile filtration, filling, and then placing it in a freeze dryer to freeze-dry to make a finished product .
[0039] After dosing according to the prescription, filter the filtrate to detect related substances, and compare it wi...
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