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Detection method and system based on GMR spin valve immune-electrochemical sensor

A technology of biosensors and detection methods, applied in instruments, measuring devices, scientific instruments, etc., can solve the problems of increasing system costs and failing to meet the needs of applications, and achieve cost-saving effects

Inactive Publication Date: 2012-01-04
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The biggest shortcoming of the existing technology is that its detection accuracy can only meet the requirements of qualitative detection, which is far from meeting the needs of the application, and an additional reference GMR spin valve chip is required to give the reference resistance value, which increases the cost of the system

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  • Detection method and system based on GMR spin valve immune-electrochemical sensor
  • Detection method and system based on GMR spin valve immune-electrochemical sensor
  • Detection method and system based on GMR spin valve immune-electrochemical sensor

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Embodiment 1

[0040]This embodiment provides a detection method based on a GMR spin valve immunobiological sensor, which is used for quantitative detection of immunomagnetic beads, thereby indirectly reflecting the concentration or specific quantity of the antigen, germ, and virus to be tested. Its purpose is to accurately convert the magnetic signal of the immune magnetic beads acting on the GMR spin valve sensor into an electrical signal, and through algorithm processing, the electrical signal strength can have a clear quantitative correspondence with the immune magnetic beads, that is, the immune magnetic beads quantitative detection.

[0041] In the method, the GMR spin valve immune biosensor is placed in a continuously changing composite scanning magnetic field, and the multiple outputs of the GMR spin valve immune biosensor are processed by an orthogonal vector algorithm to find the maximum value and Composite magnetic field offset corresponding to the maximum value, calculate the dif...

Embodiment 2

[0058] This embodiment provides a detection system based on the GMR spin valve immune biosensor using the method of the invention. The system is used for quantitative detection of immunomagnetic beads, thereby indirectly reflecting the concentration or specific quantity of the antigen, germ, and virus to be tested.

[0059] Such as Figure 4 As shown, the system includes: a GMR spin valve immune biosensor group, a constant current source connected to the GMR spin valve immune biosensor group and providing a constant current for the sensor group, and the GMR spin valve immune biosensor group A signal amplification module connected to the sensor group and used to amplify its output signal, a multiplex gate module connected to the GMR spin valve immune biosensor group and used to gate the corresponding GMR spin valve immune biosensor, for placing The solenoid of the GMR spin valve immune biosensor group, the composite magnetic field generation module connected to the solenoid an...

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Abstract

The invention discloses a detection method and system based on a GMR spin valve immune-electrochemical sensor; wherein the GMR spin valve immune-electrochemical sensor is arranged in a compound scanning magnetic field, difference of magnetic field offset corresponding to a magnetic sensitive point before and after immune magnetic beads are dropwise added on the surface of the sensor is measured, and quantity of the immune magnetic beads is calculated. The detection system based on the GMR spin valve immune-electrochemical sensor comprises a GMR spin valve immune-electrochemical sensor group, a constant flow source connected with the sensor group, a signal amplifying module and a multichannel strobe module, a solenoid used for containing the sensor group, a compound magnetic field generating module connected with the solenoid and a system control and algorithm processing module connected with the signal amplifying module, the compound magnetic field generating module and the multichannel strobe module. The invention indirectly reflects concentration or concrete quantity of antigen, pathogenic bacteria and virus to be detected by quantitative detection on the immune magnetic beads, precision is high and cost is lower.

Description

technical field [0001] The invention relates to a biological immune detection method and system, in particular to a biological immune detection method and system based on a GMR spin valve immune biosensor. Background technique [0002] In the prior art, the principle structure and working method of the GMR spin valve immune biosensor are as follows: figure 1 shown. In the figure, 1 is a non-testing organism, and a multilayer GMR spin valve immune biosensor device 7 is usually prepared on a single crystal silicon substrate 8, and then a protective layer 6 is made on the sensor device, such as nitrogen Silica, silicon dioxide, etc., and at the same time make a support layer (for better connection with biomolecules) or a biological immobilization layer 5, and finally fix the immune antibody 4 of the pathogen to be tested by the biological immobilization layer 5. When the pathogen 3 (antigen) in the sample to be tested flows through the surface of the sensor, it will generate ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/72G01N33/569
Inventor 王自鑫何振辉陈弟虎张嘉鹏胡庆荣
Owner SUN YAT SEN UNIV
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