Application of carbon monoxide-releasing molecules and heparin in preparing medicament for treating sepsis

Abstract

The invention provides application of carbon monoxide-releasing molecules and heparin in preparing a medicament for treating sepsis. The carbon monoxide-releasing molecules are combined with the ultramicro heparin to improve the coagulation defects of the sepsis, the control of the concentration of the carbon monoxide-releasing molecules and the heparin is relatively easy and correct, the carbon monoxide-releasing molecules and the heparin can be conveniently added when used for a long time, simultaneously the consumption and side effect of the heparin are reduced, and the carbon monoxide-releasing molecules and the heparin can meet the requirement of clinical application. The carbon monoxide-releasing molecules are combined with the ultramicro heparin to improve the coagulation defects of the sepsis, the control of the concentration of the carbon monoxide-releasing molecules and the heparin is relatively easy and correct, the carbon monoxide-releasing molecules and the heparin can beconveniently added when used for a long time, and the carbon monoxide-releasing molecules and the heparin can meet the requirement of clinical application.

Description

Technical field [0001] The present invention relates to a new use of carbon monoxide releasing molecules and heparin, in particular to a kind of carbon monoxide releasing molecules combined with ultrafine dose heparin, and early application of drugs for treating blood coagulation dysfunction in sepsis. Background technique [0002] Sepsis is a common complication after severe trauma, shock and infection. Further development can lead to septic shock and multiple organ dysfunction syndrome (MODS). Even in the modern era where basic and clinical medical research and intensive care methods are highly developed, Clinical treatment still has little effect, and the mortality rate remains high. Studies have shown that the mortality rate of important organ failure, especially multiple organ failure after severe sepsis, is very high. Once multiple organ failure occurs, it is difficult to reverse it with existing treatment measures, so it is particularly important to prevent or reduce orga...

AI Technical Summary

Problems solved by technology

However, single use of large doses of heparin in sepsis can cause greater damage to coagulation function

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