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Bionic enzymatic product of animal medicament and application thereof

A technology of enzymatic hydrolysis products and bionic enzymolysis, applied in the field of bionic enzymatic hydrolysis products, can solve the problems of waste of medicinal materials, waste of medicinal materials, reduction of curative effect, etc.

Inactive Publication Date: 2010-02-17
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional raw powder is taken directly. Only a small amount of macromolecular protein in the raw drug powder is decomposed in the gastrointestinal tract in the body and becomes small molecular oligopeptides to be absorbed. The interference of oral administration of other foods results in incomplete hydrolysis, less active ingredients are absorbed and utilized, resulting in a waste of a large amount of medicinal materials and a greatly reduced curative effect
The extraction process of water extraction makes most of the protein insoluble in water removed by filtration, resulting in a lot of waste of medicinal materials, and the curative effect is also greatly reduced

Method used

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  • Bionic enzymatic product of animal medicament and application thereof
  • Bionic enzymatic product of animal medicament and application thereof
  • Bionic enzymatic product of animal medicament and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Take 500g of dog bone, crush it into fine powder, add 10 times the amount of water to homogenate, adjust the pH to 2.0, add 1% of the amount of dog bone pepsin, keep it at 40°C for 2 hours, adjust the pH to 8.0, add dog bone A certain amount of 1% trypsin was incubated at 50° C. for 4 hours, spray-dried, added appropriate amount of powdered sugar and dextrin, granulated, dried, and sized to make granules.

Embodiment 2

[0046] Take 500g of pork bones, crush them into fine powder, add 8 times the amount of water to homogenate, adjust the pH to 2.6, add 2% of the amount of pig bones, pepsin, incubate at 37°C for 3 hours, adjust the pH to 7.5, add pork bones A certain amount of 2% trypsin was incubated at 40° C. for 6 hours, spray-dried, added an appropriate amount of microcrystalline cellulose, granulated, dried, sized, and pressed into tablets.

Embodiment 3

[0048] Take 500g of yak bone, crush it into fine powder, add 15 times the amount of water to homogenate, adjust the pH to 3.0, add 5% pepsin of yak bone, keep it at 40°C for 2 hours, adjust the pH to 8.5, add yak bone A certain amount of 5% trypsin was incubated at 45° C. for 5 hours, spray-dried, added appropriate amount of powdered sugar and dextrin, granulated, dried and sized to make granules.

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Abstract

The invention discloses a bionic enzymatic product of animal bones and application thereof, which belong to the field of Chinese medicament. The bionic enzymatic product is characterized in that a bionic enzymatic method is adopted, and comprises the following steps: taking animal bones; grinding the bones into fine powders; adding water into the fine powders; evenly stirring the mixture; under appropriate condition, performing heat preservation by using pepsin, and then performing heat preservation by using pancreatin or trypsase; and preparing obtained zymolyte into preparations according todifferent preparation requirements. The product of the invention has good effects in the aspects of treating fracture, wind-damp impediment pain, lassitude in loin and legs, and osteoporosis.

Description

technical field [0001] The invention relates to a biomimetic enzymatic hydrolysis product of traditional Chinese medicine animal bone and its application in treating fractures, rheumatic arthralgia, soreness of the waist and knees and osteoporosis. It belongs to the field of traditional Chinese medicine. Background technique [0002] Animal bone has been used as a traditional Chinese medicine for a long time, and its clinical application is very extensive. Tiger bone is recorded in the 77th edition of the Chinese Pharmacopoeia to strengthen muscles and bones, dispel rheumatism, and relieve pain. It is used to treat joint pain, waist and leg weakness, etc. Tiger bone first appeared in the form of medicinal wine in "Waitai Miyao" Volume 15 reproduced by Xu Wen of the Southern Qi Dynasty Bofang’s tiger bone wine, since then most of the prescriptions have contained tiger bone wine recipes, initially for single use, and gradually compounded. There are 74 tiger bone wine recipes ...

Claims

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Application Information

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IPC IPC(8): A61K35/32A61P19/08A61P19/10A61P29/00C12P21/00A61K35/57
Inventor 刘国飞周小明
Owner 北京凯瑞创新医药科技有限公司
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