Stable albumins lipid medicine carrying system and preparation method thereof
A drug-loading system and albumin technology, applied in the field of stable albumin lipid drug-loading system and its preparation, can solve the problems of inability to realize industrial production, complicated preparation process, and low drug binding rate
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[0040] 1. Paclitaxel / docetaxel albumin-lipid conjugate
[0041] Take paclitaxel / docetaxel 100mg, egg yolk lecithin 3g, cholesterol 1g, albumin 1.0g, add 50ml of chloroform and stir to dissolve paclitaxel / docetaxel, egg yolk lecithin, cholesterol, remove chloroform by distillation under reduced pressure with a rotary evaporator, add 5 grams of sucrose, PH6-7 citric acid buffer salt to a total volume of 100ml, homogenized by a high-pressure homogenizer until the particle size is 50-200nm, passed through a 0.22 filter membrane and sealed in a jar.
[0042] If a freeze-dried preparation is prepared, 2-3% phenylalanine by weight of the system is added to the above liquid and freeze-dried according to a conventional process.
[0043] If the product is to be prepared, the environment, heat source, sterility, etc. need to be completed in accordance with the requirements of mass production.
[0044] 2. Epothilone B albumin lipid conjugate
[0045] Take 50 mg of epothilone B, 1 g of e...
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