Stable albumins lipid medicine carrying system and preparation method thereof

A drug-loading system and albumin technology, applied in the field of stable albumin lipid drug-loading system and its preparation, can solve the problems of inability to realize industrial production, complicated preparation process, and low drug binding rate

Inactive Publication Date: 2010-03-17
苏州世林医药技术发展有限公司
View PDF2 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Searched domestic and foreign patents and found a pharmaceutical composition for treating cancer (application number 200510053892.2), which is a liposome combined with anti-tumor active drugs, polyethylene glycol and albumin. The drug prepared by the method used in this patent is chemically synthesized The method combines albumin on phospholipids, and polyethylene glycol is also combined with phospholipids by chemical methods. The preparation process of this composition is too complicated and the cost is very high, and it is impossible to realize industrial production and make clinically usable preparations; patent (application number 03108361.7) discloses a paclitaxel-albumin conjugate. It is found that the drug binding rate prepared by this patent is low, and it is difficult for the powdered paclitaxel to be completely combined with albumin during the preparation process.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stable albumins lipid medicine carrying system and preparation method thereof
  • Stable albumins lipid medicine carrying system and preparation method thereof
  • Stable albumins lipid medicine carrying system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0040] 1. Paclitaxel / docetaxel albumin-lipid conjugate

[0041] Take paclitaxel / docetaxel 100mg, egg yolk lecithin 3g, cholesterol 1g, albumin 1.0g, add 50ml of chloroform and stir to dissolve paclitaxel / docetaxel, egg yolk lecithin, cholesterol, remove chloroform by distillation under reduced pressure with a rotary evaporator, add 5 grams of sucrose, PH6-7 citric acid buffer salt to a total volume of 100ml, homogenized by a high-pressure homogenizer until the particle size is 50-200nm, passed through a 0.22 filter membrane and sealed in a jar.

[0042] If a freeze-dried preparation is prepared, 2-3% phenylalanine by weight of the system is added to the above liquid and freeze-dried according to a conventional process.

[0043] If the product is to be prepared, the environment, heat source, sterility, etc. need to be completed in accordance with the requirements of mass production.

[0044] 2. Epothilone B albumin lipid conjugate

[0045] Take 50 mg of epothilone B, 1 g of e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a stable albumins lipid medicine carrying system and a preparation method thereof. The method is to combine the albumins with the lipid cysts by using ultrasonic, high-pressure homogenization or micro-streaming technology, and thus can significantly improve the stability of the lipid cysts and the encapsulation efficiency of medicaments in the lipid cysts.

Description

technical field [0001] A stable albumin lipid drug-carrying system and a preparation method thereof, in which albumin is bound to lipid vesicles by ultrasonic waves, high-pressure homogenization or microfluidization techniques, which can significantly improve the stability of lipid vesicles and improve the Encapsulation efficiency of drug in lipid vesicles. Background technique [0002] Lipid vesicles are a preparation formed by encapsulating drug molecules in vesicles formed by embedding cholesterol in phospholipid bilayers. Phospholipids are the main chemical components of lipid vesicles, and the most representative one is lecithin. Lecithin mainly comes from egg yolks and soybeans, has low preparation cost, stable properties, and belongs to neutral phospholipids. Phosphatidylcholine is the main component of many cell membranes and the main raw material for the preparation of lipid vesicles. Cholesterol is also another important component of lipid vesicles. It is an impor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/24A61K47/28A61K45/00A61K9/127A61P35/00
Inventor 张文芳
Owner 苏州世林医药技术发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap