Preparation method of composite hyaluronic acid-sulfadiazine silver gel

A technology of acid sulfadiazine and silver sulfadiazine is applied in the field of preparation of compound hyaluronic acid silver sulfadiazine gel, which can solve the problems of short retention time, inability to achieve continuous antibacterial and anti-inflammatory and the like

Inactive Publication Date: 2010-03-31
上海建华精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Silver sulfadiazine is excreted in many ways in the body, but the retention time in the bod

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 0.5g of hyaluronic acid fine powder with a molecular weight of 2 million Daltons in a container filled with 100ml of medicinal sterile pure water, and stir and mix for 3 hours;

[0019] During the stirring process, keep the hyaluronic acid dissolving temperature at about 70°C to form a hyaluronic acid solution;

[0020] Then add 0.8g silver sulfadiazine, stir and mix for 2 hours;

[0021] During the stirring process, keep the hyaluronic acid dissolving temperature at about 70°C to form a silver sulfadiazine hyaluronic acid solution.

[0022] Wherein, the final concentration of hyaluronic acid is 0.005g / ml. Filled and subjected to flow-through steam sterilization (105°C, 30 minutes).

Embodiment 2

[0024] Put 0.8 g of hyaluronic acid fine powder with a molecular weight of 2.5 million Daltons in a container filled with 100 ml of medicinal sterile pure water, and stir and mix for 43 hours;

[0025] During the stirring process, keep the hyaluronic acid dissolving temperature at about 75°C to form a hyaluronic acid solution;

[0026] Then add 0.9g silver sulfadiazine, stir and mix for 2 hours;

[0027] During the stirring process, keep the hyaluronic acid dissolving temperature at about 75°C to form a silver sulfadiazine hyaluronic acid gel.

[0028] Wherein, the final concentration of hyaluronic acid is 0.008g / ml. Filled and subjected to flow-through steam sterilization (115°C, 30 minutes).

Embodiment 3

[0030] Put 0.6g of hyaluronic acid fine powder with a molecular weight of 3 million Daltons in a container filled with 100ml of pharmaceutical sterile pure water, and stir and mix for 4 hours;

[0031] During the stirring process, keep the hyaluronic acid dissolving temperature at about 80°C to form a hyaluronic acid solution;

[0032] Then add 0.7g silver sulfadiazine, stir and mix for 2 hours;

[0033] During the stirring process, keep the hyaluronic acid dissolving temperature at about 80° C. to form a silver sulfadiazine hyaluronic acid solution.

[0034] Wherein, the final concentration of hyaluronic acid is 0.006g / ml. Filled and subjected to flow-through steam sterilization (121° C., 15 minutes).

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Abstract

The invention provides a preparation method of composite hyaluronic acid-sulfadiazine silver gel. The preparation comprises hyaluronic acid and sulfadiazine silver and the preparation is prepared by dissolving hyaluronic acid at high temperature and adding the dissolved hyaluronic acid in sulfadiazine silver. The composite hyaluronic acid-sulfadiazine silver gel of the invention has good biocompatibility and long half-life, thus being applicable to all kinds of antipyrotic and antibacterial situations.

Description

technical field [0001] The invention relates to a preparation method of compound hyaluronic acid sulfadiazine silver gel. Background technique [0002] Hyaluronic Acid (HA) gel is widely used in ophthalmology, orthopedics, gynecology, plastic surgery and other fields. It has been in clinical practice for more than ten years, and its safety and effectiveness have been recognized by all medical circles. generally accepted. Natural exogenous hyaluronic acid has a molecular weight of about 100,000 to 5 million Daltons, and its retention time in the body is about 3 to 15 days, which largely limits its application in certain fields. For example, it is used for tissue filling to improve facial wrinkles and creases, improve lip shape and correct facial contours, etc.; or for bone and joint lubrication, the effect duration is too short and continuous injection is required. [0003] Silver sulfadiazine has the effect of both sulfadiazine and silver salt, has broad-spectrum antimicro...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/505A61K47/36A61P31/00
Inventor 任彩霞孔淑静侯永泰
Owner 上海建华精细生物制品有限公司
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