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Modified humic acid degradation product, preparation method and composition patch thereof

A humic acid and degradant technology, applied in the chemical field, can solve the problems of low drug efficacy, large side effects, and poor safety of diabetes drugs, and achieve the effects of promoting glycogen synthesis and decomposition, preventing hypoglycemia, and high safety factor

Inactive Publication Date: 2012-07-04
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Therefore, the technical problem to be solved in the present invention is to provide a drug for treating or preventing diabetes and its preparation method and intermediates, which are low in cost and good in safety, aiming at the shortcomings of diabetes drugs such as low drug efficacy, large side effects, and poor safety. , no drug resistance

Method used

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  • Modified humic acid degradation product, preparation method and composition patch thereof
  • Modified humic acid degradation product, preparation method and composition patch thereof
  • Modified humic acid degradation product, preparation method and composition patch thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 natural humic acid degradation products

[0027] 1000g of natural air-dried Yunnan Shiping natural peat with a humic acid content of 59% (Wt) was pulverized into 20nm particles in an ultra-high-speed pulverizer with a linear speed of 200m / s. Add 0.3mg of Penicillium (300IU), white rot fungus (1500IU), and add 100ml of water. Reaction at room temperature for 216 hours, biodegradation, and peat humic acid degradation product. Centrifuge for solid-liquid separation and take the liquid. The molecular weight of humic acid degradation product was 330 detected by freezing point depression method and capillary electrophoresis.

Embodiment 2

[0028]The synthesis of embodiment 2 organoboron intermediates

[0029] Get 1800g boric acid, 150g diethanolamine, 0.5g quaternary ammonium salt [(CH 3 ) 3 N + Cl - CH 2 COOCH 2 CH 3 ], add 10g of water, and react at 90°C for 3hr to form ethanolamine borate in an equimolar amount. Add 100 mL of 50% (wt) aqueous glycol solution, and react at a temperature of 30° C. for 25 hours to obtain the reaction product organoboron. The infrared spectrum analysis chart of the reaction product is shown in figure 1 .

Embodiment 3

[0030] The organoboron modification of embodiment 3 natural humic acid degradation product

[0031] Take 100ml of the natural humic acid degradation product liquid prepared in Example 1 and 100ml of the reaction product obtained in Example 2, and react at 85°C for 3 hours. The reaction product was filtered, dried and dehydrated by a rotary evaporator to obtain white crystals. The infrared spectrum analysis chart of the crystal is shown in figure 2 , it can be seen that it is the natural humic acid degradation product that has completed organic boron modification.

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Abstract

The invention discloses a modified humic acid degradation product, a preparation method and a composition patch thereof. The preparation method comprises the following steps: (1) pulverizing the raw material of humic acid, and adding microorganisms to carry out biodegradation, thereby obtaining the humic acid degradation product; (2) in water or organic solvent, under the action of catalyzer, carrying out reaction between boric acid and hydroxyl amine to form hydramine borate; (3) in water or organic solvent, carrying out ester exchange between hydroxyl amine and glycol to form organoboron; and (4) in water, carrying out reaction between the humic acid degradation product obtained in step (1) and the organoboron obtained in step (3) to form an organoboron modified humic acid degradation product. The modified humic acid degradation product can be made into a patch which is applied to the dantian of a patient with Type 2 diabetes; when the patient have meals, the modified humic acid degradation product can stimulate the secretion of insulin, promote the insulin to quickly secrete after meals, and enables the insulin between two meals to be independently regulated to the foundation level; and the regulating range of the blood sugar index reaches + / -20%. The invention has the advantages of high safety factor and favorable social and economic benefits.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a modified humic acid degradation product, a preparation method and a composition thereof. Background technique [0002] Impaired glucose tolerance and diabetes mellitus are metabolic diseases with multiple etiologies, characterized by chronic hyperglycemia, accompanied by relative and absolute lack of insulin in the bloodstream, resulting in disorders of sugar, fat and protein metabolism. For insulin-dependent (type I) diabetics, long-term subcutaneous injections of insulin are required, making the treatment poorly tolerated. For people with non-insulin-dependent (type II) diabetes, kidney disease, heart disease, eye disease, etc. may develop concurrently if not treated effectively. According to the latest survey of the Chinese Medical Association in 2009, the number of diabetic patients in China reached 92.4 million, accounting for 9.7% of the total urban adults. Accordin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/02A61K47/46A61K9/70A61P3/10C07G99/00C08H99/00C07F5/02
Inventor 周霞萍张义超张世万班卫静余文风曾宪成
Owner EAST CHINA UNIV OF SCI & TECH
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