Method for extracting and purifying resveratrol from polygonum cuspidatum

A technology of resveratrol and Polygonum cuspidatum, applied in the chemical field, can solve the problems of high equipment cost, excessive ash content of products, poor filtration, etc., and achieve the effects of reducing production cost, shortening production time, and reducing extraction steps.

Inactive Publication Date: 2010-05-19
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This scheme overcomes the shortcomings of using toxic organic solvents in production engineering, but it has the disadvantages of large amount of water, high pressure of subsequent treatment equipment, and high energy consumption; in addition, the temperature control of the process is too high and the range is too wide, which is easy to cause oxidative decomposition of the product ; Sodium hydroxide is used to extract the alkali, and the viscosity of the extraction solution is relatively large, which can easily lead to poor filtration; the method of directly filtering the precipitation in the aqueous solution to obtain the product will cause a large amount of resveratrol to remain in the water, resulting in a decline in the yield; the process does not consider Inorganic metal ions such as Ca 2+ removal, resulting in excessive ash content of the product
In the reports whose publication numbers are CN1513822A and CN1513823A, it is reported that microwave and supercritical CO 2 To extract the method of resveratrol, these methods equipment cost is high, is difficult for industrialized production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Crush the rhizome of Polygonum cuspidatum until it passes through a 14-mesh sieve to obtain Polygonum cuspidatum powder; weigh 4 parts of 100kg of Polygonum cuspidatum powder, place them in tank-type dynamic countercurrent extraction equipment respectively, add 15kg of ferrous sulfate and 8kg of calcium oxide each, and add 400kg of each at a concentration of 60% The ethanol aqueous solution was stirred and extracted at 40°C in batches, the primary solution was 60 minutes, the secondary solution was 50 minutes, the third solution was 40 minutes, the fourth solution was 30 minutes, and the extract was filtered by a plate and frame filter press with a filter cloth specification of 300 mesh; the extract was obtained with 001× 14.5 Cationic resin at a flow rate of 3BV h -1 , diameter-to-height ratio of 1:4 under the conditions of desalination to obtain desalted extract; the desalted extract at 40 ℃, vacuum degree -0.075MPa to recover ethanol to obtain a purified extract; the ...

Embodiment 2

[0027] The rhizome of Polygonum cuspidatum is crushed to pass through a 14-mesh sieve to obtain Polygonum cuspidatum powder; 4 parts of 100kg of Polygonum cuspidatum powder are weighed, placed in tank group dynamic countercurrent extraction equipment respectively, 17.5kg of ferric sulfate and 9kg of calcium hydroxide are added respectively, and 500kg of concentration 65 % ethanol aqueous solution, 45°C stirring and extracting in batches, the primary solution is 62min, the secondary solution is 52min, the third solution is 42min, the fourth solution is 32min, and the extract is filtered by a plate and frame filter press with a filter cloth specification of 400 mesh; the extract is obtained with 001 ×16 cationic resin at a flow rate of 4BV·h -1 , diameter-to-height ratio of 1:5.5 under the conditions of desalination to obtain desalted extract; the desalted extract at 45 ℃, vacuum degree of -0.08MPa to recover ethanol to obtain purified extract; the purified extract filled with CO...

Embodiment 3

[0029] The rhizome of Polygonum cuspidatum is crushed to pass through a 14-mesh sieve to obtain Polygonum cuspidatum powder; 4 parts of 100kg of Polygonum cuspidatum powder are weighed, placed in tank group dynamic countercurrent extraction equipment respectively, 20kg of polyferric sulfate and 10kg of calcium hydroxide are added, and 600kg of concentration 70 % ethanol aqueous solution, 50 ℃ stirring and extracting in batches, the primary solution is 65min, the secondary solution is 55min, the third solution is 45min, the fourth solution is 35min, and the extract is filtered by a plate and frame filter press with a filter cloth specification of 500 mesh; the extract is obtained with 001 ×16 cationic resin at a flow rate of 5BV·h -1 , diameter-to-height ratio of 1:7 under the conditions of desalination to obtain desalted extract; the desalted extract at 50 ° C, vacuum -0.085MPa conditions to recover ethanol to obtain purified extract; purified extract diluted hydrochloric acid ...

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Abstract

The invention discloses a method for extracting and purifying resveratrol from polygonum cuspidatum, ethanol, iron salt and alkali are used as extraction media in the method, a multi-stage dynamic countercurrent extraction technology is adopted, and the steps of desalination, purification, acidification, enzymatic hydrolysis, concentration, impurity removal and the like are sequentially carried out extraction liquid, thereby preparing a resveratrol product. The method has the advantages of simple process, short operation time, low production cost, high extraction efficiency, no organic solvent and easy industrial production.

Description

technical field [0001] The invention relates to a purification method in the chemical field, in particular to a method for extracting and purifying resveratrol from Polygonum cuspidatum. Background technique [0002] Resveratrol (Res for short) is a natural stilbene polyphenol produced in plants, and is a non-flavonoid polyphenol compound containing a stilbene structure. Resveratrol is a type of phytoalexin with special medical and health care functions and significant effects on human health. Because of its obvious effects on inhibiting cancer cells, lowering blood lipids, preventing and treating cardiovascular diseases, anti-oxidation, and delaying aging, it has become a It is another new green anti-cancer drug after paclitaxel, and is considered to be one of the most promising new anti-cancer and anti-cancer drugs for contemporary humans. At present, this substance has been widely used in food, medicine and health products and other industries, and the market demand is l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/21C07C37/68
Inventor 张强华石莹莹熊清平李东
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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