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Lotus leaf extract, monomer component and application thereof

A kind of use, technology of lotus leaf base, applied in the field of medicine

Inactive Publication Date: 2011-03-30
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, no lotus leaf alkaloids and their monomer components have been reported to inhibit the activity of acetylcholinesterase

Method used

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  • Lotus leaf extract, monomer component and application thereof
  • Lotus leaf extract, monomer component and application thereof
  • Lotus leaf extract, monomer component and application thereof

Examples

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Embodiment Construction

[0009] The present invention relates to a lotus leaf extract and its monomer components and its application. The effective monomer components of the lotus leaf extract and its monomer components are aporphine alkaloids, and its monomers are: compound 1 is 2 -Hydroxy-1-methoxyaporphine; Compound 2 is Nuciferine; Compound 3 is N-Norciferine. Its use is acetylcholinesterase inhibitor.

[0010] The effective monomer components of the total alkaloid extract of the present invention are mainly aporphine alkaloids, specifically comprising compound 1 as 2-hydroxy-1-methoxy aporphine (2-hydroxy-1-methoxy- aporphine), compound 2 is nuciferine (nuciferine), compound 3 is N-nornuciferine (N-nornuciferine), and the compound structure is as follows, wherein the skeleton numbering sequence of compounds 1-3 is the same:

[0011]

[0012] Compound 1 (2-Hydroxy-1-methoxyapo

[0013]

[0014] Compound 2 (nuciferine)

[0015]

[0016] Compound 3 (N-norciferine)

[0017] like figure ...

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Abstract

The invention relates to a lotus leaf extract, a monomer component and application thereof. An active monomer component of the extract is aporphine alkaloid and comprises 2-hydroxy-1-methoxy-aporphine, nuciferine and N-nornuciferine. The lotus leaf extract and the monomer component have good inhibition to acetylcholinesterase, and can be developed into medicaments for treating the diseases such as Alzheimer's disease, glaucoma, asthenic bulbar paralysis, intestinal obstruction and the like.

Description

technical field [0001] The present invention relates to the field of medicine. Background technique [0002] Acetylcholinesterase is a key enzyme in biological nerve transmission. In the cholinergic synapse, the enzyme degrades acetylcholine, terminates the excitatory effect of neurotransmitters on the postsynaptic membrane, and ensures the normal transmission of nerve signals in the organism. . If the activity of this enzyme is inhibited, a cholinergic effect can be produced. Acetylcholinesterase inhibitors are mainly used to prevent and treat Alzheimer's disease (Alzheimer disease is senile dementia, referred to as AD), and also have a good effect on the treatment of glaucoma, myasthenia gravis, intestinal obstruction and other diseases (Jin You Yu. Pharmacology (Fifth Edition), 2001; 54-55.). [0003] Alzheimer's disease (AD) is a degenerative brain disease characterized by progressive dementia, which seriously affects the cognitive function, memory function, personal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D221/18C07G5/00A61K31/473A61K36/62A61P25/28A61P27/06A61P1/00A61P21/04
Inventor 杨中铎张旭杨明俊张东博任晋
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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