Method for structuring model for culturing genital tubercle organ for urethra ectogenesis

A technology for in vitro development and organ culture, applied in the fields of artificial cell constructs, biochemical equipment and methods, measurement/testing of microorganisms, etc., can solve the problems of complex mechanism, shortage, inconvenience, etc., and achieve a reasonable and easy-to-operate Effect
CN101712946AInactive Publication Date: 2010-05-26AFFILIATED HOSPITAL OF NANTONG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
AFFILIATED HOSPITAL OF NANTONG UNIV
Publication Date
2010-05-26
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a method for structuring a model for culturing genital tubercle organ for urethra ectogenesis, comprising the following steps of acquiring a mouse with accurate preggnancy, identifying embryo sex, cutting and culturing the genital tubercles, identifying the cultured genital tubercles, and the like. The invention has the advantages of reasonable route and easy operation andprovides an effective tool for further researching penile urethra development mechanism and genitalia malformation pathogenesis.
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Description

Technical field:

[0001] The invention relates to a method for constructing a urethral in vitro development model of genital tuberculosis organ culture. Background technique:

[0002] The pathogenesis of hypospadias is multifactorial and the mechanism is complicated. Genetic factors are one of the reasons for the occurrence of hypospadias. However, in recent years, the increase of endocrine disrupting chemicals in the environment, especially the increase of estrogen intake is considered to be the reason for the incidence of hypospadias. A key factor of the increase, we have successfully established an animal model of estrogen-induced hypospadias to study the relationship between some endocrine disrupting chemicals and penile development, especially revealing the mechanism is crucial for the prevention and treatment of hypospadias , but there is currently a lack of relevant tools for the study of penis development. Animal model studies are effective but inconvenient. The devel...

Claims

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