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Medium pressure chromatogram purification column

A chromatographic purification and purification column technology, which is applied in the design and filling field of medium-pressure chromatographic purification columns, and can solve the problems of mobile phase leakage sealing device, high manufacturing cost and use cost, shedding, etc.

Inactive Publication Date: 2010-06-02
天津博纳艾杰尔科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the existing medium-pressure chromatographic purification columns are disposable purification separation columns, which have the disadvantages of high manufacturing cost and high use cost
Other detachable and reusable purification columns often have mobile phase leakage or even the sealing device falls off during use

Method used

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Examples

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Embodiment Construction

[0023] figure 1 A schematic diagram showing the structure of a medium-pressure chromatographic purification column. The medium-pressure chromatographic purification column with a cylindrical structure includes a column body 1 molded with an outlet pipe 11 and a reinforcing rib 13 , a sealed inner plug molded with an inlet pipe 21 and a perforated gland 3 . During operation, the mobile phase flows from the inlet pipe 21 into the medium-pressure chromatographic purification column, and flows through the packing material to the outlet pipe 11 .

[0024] figure 2 The medium-pressure chromatographic purification column is shown to include 5 parts in turn: a column body 1 molded with an outlet pipe 11, a molded diversion groove 12, an external thread 14 and a reinforcing rib 13; an inlet pipe 21, a molded A sealing inner plug 2 with a distribution groove 23 and a groove 22; a perforated gland 3 with a through hole 31 and an internal thread 32; an inlet filter 4; an outlet filter ...

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Abstract

The invention discloses a medium pressure chromatogram purification column, consisting of three parts: a column body connected with an outlet pipe, a sealing inner plug connected with an inlet pipe and a perforation gland. Two filtering sheets are respectively arranged at an outlet end and an inlet end in the column body so as to prevent the filler in the column from overflowing under pressure. The port of the inlet end of the column body is hermetically connected with a groove of the sealing inner plug. The perforation gland can be screwed on the column body by hands so as to realize the sealing. The invention has reasonable structure, convenient industrial production and strong bearing capacity. The process of mounting and dismounting is simple and can be used repeatedly. The medium pressure chromatogram purification column can be used as a disposable object because of low cost.

Description

technical field [0001] The invention belongs to the technical field of chromatographic separation, and relates to a design and filling method of a reusable medium-pressure chromatographic purification column with simple manufacture, good sealing performance, strong pressure bearing capacity. It is mainly used for separation and purification of substances in organic synthesis and pharmaceutical industry. Background technique [0002] Medium pressure chromatographic purification column is a widely used analytical chromatographic technique. The principle is that when the components dissolved in the mobile phase pass through the stationary phase, due to the different sizes and strengths of the interactions (adsorption, distribution, ion attraction, exclusion, affinity) with the stationary phase, the residence time in the stationary phase is different. Different, thus successively flow out from the stationary phase, to achieve the purpose of separation. [0003] At present, mos...

Claims

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Application Information

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IPC IPC(8): B01D15/22
Inventor 汪群杰张北京许平
Owner 天津博纳艾杰尔科技有限公司
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