Polymer/amphoterics/aqueous two-phase system, preparation method and application thereof

A surfactant, two-phase system technology, applied in separation methods, chemical instruments and methods, solvent extraction, etc., can solve problems such as high viscosity and unfavorable operation, and achieve good phase-forming effect, stable phase behavior, and phase-forming. fast effect

Inactive Publication Date: 2010-06-09
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the high viscosity of the traditional polymer / polymer two-phase system, which is not conducive to operation, and the large amount of inorganic salt introduced by the polymer / inorganic salt system will cause environmental problems, therefore, in recent years, biodegradable The degraded organic salt and surfactant system have attracted the attention of scholars, but the two-phase aqueous system composed of polyethylene glycol and two-phase surfactant has not been reported at home and abroad.

Method used

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  • Polymer/amphoterics/aqueous two-phase system, preparation method and application thereof
  • Polymer/amphoterics/aqueous two-phase system, preparation method and application thereof
  • Polymer/amphoterics/aqueous two-phase system, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Add a certain amount of known concentration of polyethylene glycol (polyethylene glycol molecular weight is 20000, i.e. PEG20000) and cocamidopropyl betaine (Cocamidopropyl Betaine) in a 10ml glass centrifuge tube, add water to make the total weight of the system approx. 10g, turn it upside down and mix well, put it in a temperature-controlled centrifuge (25°C, 3000rpm, 30min), and put the centrifuged system in a 25°C constant temperature water bath for 24 hours to ensure the balance of the system and form Polyethylene glycol / cocamidopropyl betaine / water two-phase system, then take it out, record the volume of the two phases, and take out the upper and lower phases respectively.

[0018] Use an elemental analyzer (vario EL) to analyze the mass fractions of C, H, and N elements in the two-phase aqueous system: use the elemental composition of betaine molecules and polyethylene glycol molecules in the system to calculate the composition of the two phases , the results are...

Embodiment 2

[0023] The two-phase phase equilibrium result of macrogol 10000 / cocamidopropyl betaine / water system, experimental procedure is exactly the same as embodiment 1, and the results are shown in Table 2 and figure 2 . The data in the figure and the table are all mass percentages.

[0024] Table 2 Phase equilibrium data of polyethylene glycol 10000 / cocamidopropyl betaine / water system, 25℃

[0025]

Embodiment 3

[0027] The two-phase phase equilibrium result of macrogol 2000 / cocamidopropyl betaine / water system, experimental procedure is exactly the same as embodiment 1, and the results are shown in Table 3 and image 3 . The data in the figure and the table are all mass percentages.

[0028] Table 3 Phase equilibrium data of polyethylene glycol 2000 / cocamidopropyl betaine / water system, 25℃

[0029]

[0030]

[0031] The phase diagram of the polyethylene glycol / cocamidopropyl betaine / water system of the present invention can be divided into a single-phase region, a two-phase region and a liquid-solid phase region. When the molecular weight of polyethylene glycol is greater than 10,000, the mutual solubility of the two phase-forming substances is small, and the connecting line is symmetrical, which is similar to the usual high polymer-high polymer type aqueous two-phase system.

[0032] In the polyethylene glycol / cocamidopropyl betaine / water two-phase aqueous system in the above-...

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Abstract

The invention discloses a polymer/amphoterics/aqueous two-phase system, belonging to the technical field of aqueous two-phase systems. In the polymer/amphoterics/aqueous two-phase system, the polymer is polyethylene glycol, the amphoterics is cocamidopropyl betaine and the formed aqueous two-phase system is polyethylene glycol/ocamidopropyl betaine/ aqueous two-phase system comprising 0-30 percent by weight of polyethylene glycol, 0-40 percent by weight of cocamidopropyl betaine and the balance of water by mass ratio. The aqueous two-phase system is formed without restriction of the adding order, has high phase-forming speed, good phase-forming effect, wider temperature operation range, stable phase behavior and little influence by temperature. The aqueous two-phase system is a novel separation method under moderate separation environment and is applicable to separation of biological matter or other high value-added products.

Description

technical field [0001] The invention belongs to the technical field of two-phase aqueous systems, in particular to a polymer / amphophoteric surfactant / water two-phase aqueous system and its preparation method and application. Background technique [0002] As an important chemical process, the separation process is indispensable in many fields such as petroleum refining, natural product extraction, pharmaceutical industry, and biochemical industry. The two-phase aqueous system has the advantages of avoiding the use of a large amount of organic solvents, easy operation, and less impact on the environment. Since its discovery, it has been widely used in the separation and purification of biomolecules, cells, and ions. Currently developed systems include polymer / polymer two-phase aqueous systems (such as polyethylene glycol / dextran), high polymer / inorganic salt two-phase aqueous systems (such as polyethylene glycol / sodium phosphate), Recently, more popular studies include anioni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/00
Inventor 秦炜游晓艳黄焱戴猷元
Owner TSINGHUA UNIV
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