Method for preparing block polymer micelle freeze-drying preparation carrying docetaxel

A technology of block polymer and docetaxel, which is applied in the field of medicine and chemical industry, can solve the problems of inconvenient, unsolved, low drug safety, etc. in clinical medicine, prolong the residence time in the body, and is suitable for clinical application. , the effect of increasing solubility
CN101732234AInactive Publication Date: 2010-06-16SHANDONG UNIV
0 Cites 21 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2010-06-16
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for preparing a block polymer micelle freeze-drying preparation carrying docetaxel, which uses a PEO-PPO-PEO block polymer as a micelle carrier to wrap the docetaxel inside the micelle and comprises the following steps: (1) dissolving the carrier and the docetaxel into an organic solvent to make the PEO-PPO-PEO block polymer and the docetaxel fully dissolved in the organic solvent, and then preparing aqueous solution of the docetaxel micelle by using the PEO-PPO-PEO block polymer as the carrier; and (2) adding a freeze-drying protective agent into the aqueous solution of the PEO-PPO-PEO block polymer carrying micelle, and filtering, sterilizing and freeze-drying the mixture to obtain freeze-drying preparation of the carrier micelle system. The block polymer micelle freeze-drying preparation carrying the docetaxel can increase the dissolubility, metabolic stability and in vivo circulation time of the docetaxel, reduce the toxicity and improve the bioavailability, and is more suitable for clinical application.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a preparation method of a docetaxel-loaded block polymer micelle freeze-dried preparation, which belongs to the technical field of medicine and chemical industry. Background technique

[0002] At present, effective measures to conquer cancer include surgery, radiotherapy, chemotherapy, etc., but they all have their limitations. For example, radiotherapy and chemotherapy generally have toxic side effects such as killing healthy red and white blood cells, liver and kidney toxicity, and nervous system damage. Therefore, the development of effective anticancer drugs has become a long-term key research topic in the world's medical circles.

[0003] Docetaxel is a paclitaxel antineoplastic drug that has been approved by the U.S. Food and Drug Administration as a cancer treatment drug. It plays an antitumor role by interfering with the microtubule network necessary for cell mitosis and interphase cell functions. Docetaxel can bind to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More