63 results about "PEO-PPO-PEO" patented technology

3,4-Dihydroxyphenyl-L-alanine (DOPA) is an unusual amino acid found in mussel adhesive proteins (MAPs) that form tenacious bonds to various substrates under water. DOPA is believed to be responsible for the adhesive characteristics of MAPs. This invention relates to a route for the conjugation of DOPA moieties to various polymeric systems, including but not limited to poly(ethylene glycol) or poly(alkylene oxide) systems such as poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers.

The invention discloses a hollow mesoporous silica microsphere with hollow core and adjustable mesopore and penetrating through a shell, preparation method and application thereof. The hollow mesoporous silica microsphere is obtained by the following steps: under the condition of acid or alkaline solution, taking hexadecyl trimethyl ammonium bromide or PEO-PPO-PEO triblock copolymer as template, adding non-polar solvent, stirring at a certain temperature, emulsifying, then adding silica source, after hydrolysis and condensation, filtering, drying, and roasting to remove the template. The preparation method has simple technique and short time, easy operation and low cost, the prepared microsphere comprises both macropore and mesopore structures, the mesopore penetrates through the shell, the aperture thereof is larger than 5nm and is adjustable within the range of 5-20nm, and by relatively large mesopore channel, internal and external transmissions of large guest molecules can be realized. The microsphere can be used as drug carrier, the drug loading amount can exceed 50% (mass percentage), and the drug release can be controlled by adjusting aperture of the mesopore and dissolutionrate of indissolvable drug can be improved.

The invention relates to preparation of a mesoporous carbon nanosheet and application of the mesoporous carbon nanosheet as an electrode material in a super capacitor. According to the method, a porous magnesium oxide nanosheet is used as a template, dopamine is used as a carbon precursor, a carbon source is uniformly coated on the surface of the magnesium oxide nanosheet to form a complex, the complex is carbonized at a high temperature, and the magnesium oxide of the template is removed with excess sulfuric acid solution to obtain a two-dimensional carbon nanosheet. Triblock copolymer PEO-PPO-PEO (Polyethylene Oxide-Polyphenylene Oxide-Polyethylene Oxide) added in a preparation process is used as a structure directing agent to form a mesoporous structure, so that the specific surface area and the pore capacity of the carbon nanosheet are improved and transmission and diffusion of electrolyte ions are facilitated to improve the electric capacity of the material. The coating thickness of the carbon source on the surface of the template can be effectively controlled by adjusting the mass ratio of the template to the carbon source and the polymerization reaction time of the dopamine, and correspondingly the carbon nanosheets with different thicknesses are obtained, so that the electrochemical performance of the carbon nanosheet is affected.

The invention discloses a hydrophilic polyvinylidene fluoride hollow fiber composite membrane and a preparation method. The aperture of the membrane is 0.01 to 0.1 micron; the porosity of the membrane is 60 to 80 percent; a polyvinylidene fluoride (PVDF) film is coated on the outer surface of a hollow woven fiber pipe; the thickness of the coating is 0.1 to 0.4 millimeter; the outer diameter of the membrane is 1.5 to 2.5 millimeters; and the PVDF film comprises the following components in percentage by mass: 80 to 95 percent of polyvinylidene fluoride, and 5 to 20 percent of amphiphilic copolymer, namely polyoxyethylene / polyoxypropylene / polyoxyethylene (PEO-PPO-PEO). The preparation method sequentially comprises the following steps of: preparing film casting solution, coating the hollow woven fiber pipe, forming a coagulating bath, cleaning, drying and the like. The hollow fiber composite membrane prepared by the method is stable and long-lasting in structure; the hydrophily of the membrane can be obviously improved; and the production cost is reduced and mass production is easy to realize by the method.

A composition for copper plating and associated methods, a method of forming a copper wiring including forming an insulation layer having a recessed portion on a substrate, and forming a copper layer on the insulation layer to fill the recessed portion by performing an electroplating process using a composition that includes an aqueous electrolyte solution containing a copper ion and at least one of a disulfide compound represented by Formula 1, a betaine compound represented by at least one of Formulae 3 and 4, and a triblock copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) having a weight average molecular weight of about 2,500 to about 5,000 g / mol and an ethylene oxide content (EO %, w / w) of about 30% to about 60%.

Polymers which comprise polymer chains of terpolymer type which are constituted by poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) of PEO-PPO-PEO form, which are modified at their termini by groups which can essentially be other chains of PEO-PPO-PEO, acid segments, amine groups or PEOs, these chains being linked to the terpolymer chains via chemical bridges which are constituted by urethane bridges, urea bridges, allophanate bridges and biuret bridges, and which comprise more than 80% by weight of said PEO-PPO-PEO.Thermoreversible physical gels of high viscosification index, which contain these polymers, and their uses.Preparation of these polymers and of these gels.

The present invention provides a safe hyaluronic acid base material that is suitable for use in practical hyaluronic acid pharmaceutical preparations capable of distribution at room temperature and having such a low viscosity that injection is easy. The hyaluronic acid pharmaceutical preparations can reside in a joint cavity for a prolonged period of time while exhibiting analgesic effects. More specfically, there is provide a hyaluronic acid modification product in which hyaluronic acid and / or a pharmaceutically acceptable salt thereof is bounded to a block polymer selected from PEO-PPO-PEO, PPO-PEO-PPO, PEO-PLGA-PEO, PLGA-PEO-PLGA, PEO-PLA-PEO and PLA-PEO-PLA. The hyaluronic acid modification product, despite capability of distribution at room temperature and ease in handling because of the low viscosity, can have its viscoelasticity rapidly increased after injection into a living body, so that it is highly useful in treatment of joint diseases, aid in surgical operation, repair of tissue, etc. as a main ingredient of novel and practical hyaluronic acid pharmaceutical preparations.

The invention relates to a preparation method for nanoscale transition metal nitride / carbon composite material, the chemical formula of nanoscale transition metal nitride / carbon composite material is MeN / C (Me is one or a mixture of more of organic compounds such as titanium, vanadium, chromium, nickel, manganese, molybdenum and the like; N and C are respectively nitrogen and carbon); the anoscale transition metal nitride / carbon composite material is obtained by the following methods: a tri-block copolymer P123 of PEO-PPO-PEO is taken as a template, the tri-block copolymer P123 and the urea resin, melamine resin or carbon nitride polymer are mixed and heated so as to obtain mesoporous carbon nitride, then the mesoporous carbon nitride is added into a metal organic compound or an ethanol solution of various mixtures of the metal organic compound, the removal of air in holes by decompression after ultrasonic vibration is carried out on the mixture, and finally the nanoscale transition metal nitride / carbon composite is obtained after the mixture undergoes ethanol pumping filtration, is scrubbed, dried and processed at high temperature under the protection of inert gas; and the product is uniform and is environmental friendly.

Polymers which comprise polymer chains of terpolymer type which are constituted by poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) of PEO-PPO-PEO form, which are modified at their termini by groups which can essentially be other chains of PEO-PPO-PEO, acid segments, amine groups or PEOs, these chains being linked to the terpolymer chains via chemical bridges which are constituted by urethane bridges, urea bridges, allophanate bridges and biuret bridges, and which comprise more than 80% by weight of said PEO-PPO-PEO. Thermoreversible physical gels of high viscosification index, which contain these polymers, and their uses. Preparation of these polymers and of these gels.

The present invention provides a safe hyaluronic acid base material that is suitable for use in practical hyaluronic acid pharmaceutical preparations capable of distribution at room temperature and having such a low viscosity that injection is easy. The hyaluronic acid pharmaceutical preparations can reside in a joint cavity for a prolonged period of time while exhibiting analgesic effects. More specfically, there is provide a hyaluronic acid modification product in which hyaluronic acid and / or a pharmaceutically acceptable salt thereof is bounded to a block polymer selected from PEO-PPO-PEO, PPO-PEO-PPO, PEO-PLGA-PEO, PLGA-PEO-PLGA, PEO-PLA-PEO and PLA-PEO-PLA. The hyaluronic acid modification product, despite capability of distribution at room temperature and ease in handling because of the low viscosity, can have its viscoelasticity rapidly increased after injection into a living body, so that it is highly useful in treatment of joint diseases, aid in surgical operation, repair of tissue, etc. as a main ingredient of novel and practical hyaluronic acid pharmaceutical preparations.

The invention provides a moldable bone repairing material for bone repairing. The material is prepared from the following raw materials in parts by weight: 20-90 parts of alpha-calcium sulfate hemihydrate and hydroxyapatite, 20-40 parts of bioactive mineral powder, 10-80 parts of autologous bone powder particles or DBM (demineralized bone matrix) particles, and hydrogel, wherein the ratio of hydrogel to the total usage of the raw materials is 1:0.5-1:15, the hydrogel is optimally PEO-PPO-PEO (polyoxyethylene-polyoxypropylene-polyoxyethylene) segmented copolymer solution. The prepared moldable bone repairing material for bone repairing is applicable to in-situ curing after wound injection and in-vitro quick curing for bone repairing, wherein all components are proved to be degradable materials with excellent biocompatibility.

The invention discloses a method for preparing a block polymer micelle freeze-drying preparation carrying docetaxel, which uses a PEO-PPO-PEO block polymer as a micelle carrier to wrap the docetaxel inside the micelle and comprises the following steps: (1) dissolving the carrier and the docetaxel into an organic solvent to make the PEO-PPO-PEO block polymer and the docetaxel fully dissolved in the organic solvent, and then preparing aqueous solution of the docetaxel micelle by using the PEO-PPO-PEO block polymer as the carrier; and (2) adding a freeze-drying protective agent into the aqueous solution of the PEO-PPO-PEO block polymer carrying micelle, and filtering, sterilizing and freeze-drying the mixture to obtain freeze-drying preparation of the carrier micelle system. The block polymer micelle freeze-drying preparation carrying the docetaxel can increase the dissolubility, metabolic stability and in vivo circulation time of the docetaxel, reduce the toxicity and improve the bioavailability, and is more suitable for clinical application.

The invention discloses a legume-shaped carbon-coated manganese oxide core-shell structure composite material and a preparation method and application thereof. The preparation method comprises the following steps: firstly, with a triblock copolymer polyethylene oxide-polypropylene oxide-polyethylene oxide PEO-PPO-PEO (P123) and polyvinyl pyrrolidone (PVP) as surfactants and potassium permanganate as a manganese source, carrying out hydrothermal reaction so as to obtain a precursor nano wire of manganese; then with dopamine as a carbon source, uniformly wrapping a layer of thin polydopamine on the surface of the precursor, and carbonizing for a certain period at a high temperature so as to prepare the legume-shaped carbon-coated manganese oxide core-shell structure composite material. Due to the wrapping of the carbon layer, the electron conductivity of the manganese oxide is improved; due to the large space among the manganese oxide active material, the volume expansion in the repeated charging and discharging process is effectively buffered; and the electrochemical test result shows that the material serving as a lithium ion battery cathode material has excellent multiplying power and circulation property, and the material is expected to be widely applied to the field of lithium ion batteries.

A rigid gas permeable lens care composition. The composition includes a disinfecting amount of at least one biguanide antimicrobial agent and a straight chain polyether surfactant based upon PEO-PPO-PEO, PPO-PEO-PPO and combinations thereof. In one embodiment, the straight chain polyether surfactant has an HLB value of less than or equal to 15 and an average molecular weight value of between about 5000 and 7000. Preferably, no rubbing is required to disinfect the rigid gas permeable contact lenses is required. Methods of making and using the same are also described.

The invention belongs to the technical field of advanced porous materials, and particularly relates to mesoporous P25 titanium dioxide microspheres and a preparation method thereof. By a solvent evaporation-induced self-assembly method, a commercial amphiphilic triblock copolymer PEO-PPO-PEO is used as a templating agent, organic titanium is used as a titanium source, inorganic acid is used as a titanium dioxide skeleton crystal modifier, a rutile-anatase coexistent skeleton with uniform spherical morphology and divergent mesoporous channels is formed during solvent evaporation, and after the templating agent is removed by roasting, the mesoporous P25 titanium dioxide microspheres are obtained. The mesoporous P25 titanium dioxide microspheres have a large specific surface area and large pore volume; in the skeleton, rutile and anatase are closely packed and the ratio is adjustable, so that the separation efficiency of photogenerated charges and photogenerated holes of a material is significantly improved, and thus the photoelectric conversion efficiency and the efficiency of a reaction for producing hydrogen through photocatalytic water decomposition are greatly improved. The preparation method is simple, a wet preparation process is adopted, raw materials are easy to obtain, and the preparation method is suitable for large-scale production and has a wide application prospect in the fields of environment, energy resources and catalysis and many other fields.

The invention discloses injectable hydrogel as well as a preparation method and application thereof. The hydrogel comprises a hyaluronic acid derivative HA-ADH modified by hydrazide groups, an aldehyde bi-functionalized hyaluronic acid derivative A-HA-Dop modified by catechol in a side chain as well as an aldehyde group terminated polyoxyethylene-polypropylene oxide-polyoxyethylene triblock copolymer A-PEO-PPO-PEO-A. On one hand, the aldehyde group terminated A-PEO-PPO-PEO-A can be self-assembled into micelle, and a first network of hydrogel can be constructed by use of the characteristic of thermosensitive sol-gel conversion; and on the other hand, aldehyde groups on the surface of the A-PEO-PPO-PEO-A micelle and aldehyde groups on the A-HA-Dop can form acylhydrazone bonds with hydrazidegroups on the HA-ADH in a physiological environment to construct second and third crosslinked networks of hydrogel. By physical acting force and reversible dynamic covalent bond acting force, the injectable multi-network crosslinked hydrogel (HA-Dop / PF) which has dual response to pH and temperature and is rapid in self-healing, high in stability, high in adhesion and easy to extend and compress isobtained, and the hydrogel can be applied to biomedicine fields of tissue repair materials and drug controlled release.

The invention relates to a preparation method of an alpha-FeOOH nano rod with uniform appearance, which belongs to the technical field of inorganic nonmetal nano material preparation. The preparation method of the alpha-FeOOH nano rod provided by the invention comprises the steps of: adding ethanol and the triblock copolymer of polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO-PPO-PEO) into the mixed aqueous solution of Fe<3> and Fe<2+>, then adding an NaOH solution until the pH of the mixed solution is 10-11, stirring and aging the mixed solution for 24 hours at room temperature to obtain a suspension, filtering or centrifugalizing the suspension to obtain solid precipitate, washing and then drying the precipitate at 30-50 DEG C to obtain the alpha-FeOOH nano rod. The alpha-FeOOH nano rod has uniform appearance, diameter of 20nm and length of 200-300nm, and can be used in the fields of dyeing, catalysis, gas detection, magnetic record, and the like. The preparation method which is simple and accessible can be implemented at normal temperature and normal pressure, thus remarkably reducing production cost.

PEO-PPO-PEO polymers and vinyl monomers are used to prepare several block copolymers via consecutive atom transfer radical polymerization (ATRP). The block copolymers provide good delivery characteristics and can be used as a gene / drug delivery carrier for therapy and diagnosis.

Biocompatible particles, according to the present invention, have encapsulated nanoparticles comprising a liposome including a drug therein, and comprise a PEO-PPO-PEO copolymer which is associated on a surface of the liposome. The biocompatible particles, according to the present invention, can flexibly control a drug release rate regardless of the solubility unique to the drug due to increased stability in an aqueous solution, thereby exhibiting continuous drug release. Also, the present invention exists stably in a powder form, thereby providing convenience for storage and administration. Therefore, the biocompatible particles according to the present invention can be useful as a drug delivery carrier.

The invention relates to the technical field of well drilling fluid lubricants, and especially relates to a thermo-sensitive and controllable-release lubricant used for a well drilling fluid and a preparation method for the lubricant. According to the lubricant, an interface synergistic effect of a composite surfactant and nano particles is adopted to control emulsion stability, a thermo-sensitive polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer (PEO-PPO-PEO block copolymer) is added to control the release speed of the lubricant, and the lubricant has the characteristics of high lubricating performance, persistent usage, a temperature controllable release and the like. The thermo-sensitive and controllable-release lubricant used for the well drilling fluid comprises the following components, in percent by mass: 15-25% of white oil, 10-20% of oleamide, 3-6% of the PEO-PPO-PEO block copolymer, 2-5% of nano calcium carbonate, 3-5% of polyoxyethylene sorbitan fatty acid ester, 1-3% of sorbitan fatty acid ester, 0.1-0.5% of an antifoaming agent, and the balance of water.

The invention provides a three-dimensional (3D) multi-stage structure VS2 hydrogen evolution electrocatalyst and a preparation method thereof. The electrocatalyst has a ball-flower-like spherical structure formed by stacking VS2 nanosheets. The preparation method comprises the steps of soaking a conductive carbon base in dispersoid containing Na3VO4.12H2O, CH3CSNH2 and a polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer (PEO-PPO-PEO) which have a molar ratio of (1-3) to (4-6) to (0.1-0.4), and carrying out a hydrothermal reaction to obtain the 3D multi-stage structure VS2 hydrogen evolution electrocatalyst. The nanosheets prepared by the method grow on a carbon cloth substrate so as to form a nano-flower with a 3D multi-stage structure. The 3D multi-stage structure nano-flower is very beneficial to free in and out of ions so as to expose more active sites, thus improving the electro-catalysis hydrogen evolution performance.

The invention discloses a manganese sesquioxide nano-structure with a hollow cone shape and a preparation method thereof. The cavity of a hollow cone has the diameter being 60-100nm and the wall thickness being 20-30nm. The preparation method comprises the following steps of: with a tri-block copolymer PEO-PPO-PEO (P123) as a structure-directing agent, dissolving the structure-directing agent in an aqueous solution, then adding co-reducer carbon powder and manganese nitrate, dispersing and mixing, adding potassium permanganate, stirring for a period of time, carrying out hydro-thermal treatment at a certain temperature, washing to obtain manganese dioxide hollow cone / carbon composite material; and baking the manganese dioxide hollow cone / carbon composite material for a period of time in 550 DEG C-air to obtain a manganese sesquioxide hollow nanometer cone with high purity. The preparation method disclosed by the invention is simple in a reaction process and easy to control. The manganese sesquioxide structure is novel in structure and has good application prospect in fields of energy storage, catalysis and the like.

The invention relates to the nanometer biomaterial field, in particular to a triblock copolymer PEO-PPO-PEO / calcium phosphate nanometer composite material and a preparation method thereof. The microscopic particles of the nanometer composite material have calcium phosphate coated triblock copolymer PEO-PPO-PEO structure; wherein, the weight percent of triblock copolymer PEO-PPO-PEO is 5-40% of the total weight of the nanometer composite material and the weight percent of calcium phosphate is 60-95% thereof. The nanometer composite material of the invention can be used as drug carrier, has higher drug-loading rate and excellent slow release performance on water-insoluble drugs and has good application prospect in the Biomedical field; the preparation method is characterized of simple process, convenient operation, lower cost and environmentally friendly and can be operated at room temperature.

A rigid gas permeable lens care composition. The composition includes a disinfecting amount of at least one biguanide antimicrobial agent and a straight chain polyether surfactant based upon PEO-PPO-PEO, PPO-PEO-PPO and combinations thereof. In one embodiment, the straight chain polyether surfactant has an HLB value of less than or equal to 15 and an average molecular weight value of between about 5000 and 7000. Preferably, no rubbing is required to disinfect the rigid gas permeable contact lenses is required. Methods of making and using the same are also described.

The invention discloses a preparation method for an iron-loading mesoporous carbon material, as well as a product and application thereof. In the condition of no alkali, a soft template method is adopted to synthesize the iron-loading ordered mesoporous carbon material in one step; polyoxyethylene-polyphenyl ether-polyoxyethylene triblock copolymer PEO-PPO-PEO(F127) is taken as a template; 1,3,5-trimethylbenzene, resorcinol and hexamine are added to synthesize ordered mesoporous polymer intermediate, and then, ferric citrate is added to prepare the iron-loading ordered mesoporous carbon material. The iron-loading mesoporous carbon material prepared with the preparation method has the advantages of high specific surface area, uniform aperture and good magnetism, and shows a good adsorptionfunction on the aspect of organic pollutant adsorption, and pollutants can be quickly separated.

The invention discloses a special epoxy resin potting adhesive The special epoxy resin potting adhesive for ignition coils comprises a component A and a component B in a mass ratio of 5:1. The component A comprises the following ingredients in parts by mass: 100 parts of bisphenol A epoxy resin, 0.1-0.2 part of PEO-PPO-PEO (polyoxyethylene-polypropylene oxide-polyoxyethylene) triblock copolymer, 20-25 parts of carboxy-terminated liquid nitrile-butadiene rubber, 10-20 parts of micro silicon powder, 5-10 parts of aluminum hydroxide and 5-10 parts of ethylene glycol diglycidyl ether. The component B comprises the following ingredients in parts by mass: 100 parts of liquid methyltetrahydrophthalic acid, 0.5-1 part of PEO-PPO-PEO triblock copolymer and 20-25 parts of calcium carbonate. The special epoxy resin potting adhesive has the effect of lowering water absorptivity.

A composition for plating copper includes an electrolyte solution, an accelerator, a suppressor and a leveler. The electrolyte solution includes a soluble copper salt, sulfuric acid and hydrochloric acid. The accelerator includes about 20 to about 60 ppm of a disulfide compound. The suppressor includes about 40 to about 100 ppm of a polyethyleneoxide (PEO)-polypropyleneoxide (PPO)-polyethyleneoxide (PEO) triblock copolymer. The PEO-PPO-PEO triblock copolymer has a weight average molecular weight of about 300 to about 10,000. The leveler includes about 0.01 to about 100 ppm of arylated polyethyleneimine.

The invention discloses a method for the carboxylation of a polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer. The method comprises the following steps: allowing the addition reaction of an unsaturated nitrile compound and PEO-PPO-PEO block polymer in an aqueous solution in the presence of alkaline catalysts, hydrolyzing nitrile groups contained in the addition reaction product under alkaline or acidic conditions, extracting the crude product of carboxyl PEO-PPO-PEO block polymer from the hydrolysate by using organic solvents, and purifying by ether precipitation method to obtain a purified carboxyl PEO-PPO-PEO block polymer. The method has mild conditions and avoids the cleavage of ether bonds in PEO-PPO-PEO block polymer. Corresponding chemical bonds can be introduced to the original polymer structure during the carboxylation process as required so as to produce a modified product with uniform structure and stable performance. Furthermore, the method is suitable for mass preparation and industrial production.

The invention discloses a preparation method of an aldehyde-free modified soybean protein adhesive. The preparation method comprises the following steps of (1) mixing defatted soybean protein powder,urea, calcium dihydrogen phosphate, sodium chloride and water, stirring for reacting at 45-52 DEG C for 9-12 hr, and naturally cooling to room temperature; (2) putting premixed zinc carbonate, nicotinamide and a P123 type PEO-PPO-PEO embedded segment copolymer into a reaction system of step (1), stirring for reacting at 65-72 DEG C for 1-3hr, naturally cooling to room temperature, wherein the massratio of defatted soy protein powder, urea, calcium dihydrogen phosphate, sodium chloride, water, zinc carbonate, niacinamide to the P123 type PEO-PPO-PEO embedded segment copolymer is 40-50:4-5:0.5-1.0:0.2-0.3:100:1-2:2-3:7-9; the water-resistant bonding strength is improved.

An intravenous delivery system may have a plurality of components with interior surfaces that cooperate to define a fluid pathway through which fluid flows into a body of a patient. One or more anticoagulant coatings may reside on one or more of the interior surfaces to restrict blood clot formation in the fluid pathway. Manufacture of the intravenous delivery system may commence with provision of the components and preparation of an anticoagulant solution. The one or more interior surfaces may be exposed to the anticoagulant solution to form the anticoagulant coating. The anticoagulant coating may be caused to adhere to the one or more interior surfaces. The anticoagulant solution may be prepared by dissolving a triblock copolymer, such as PEO-PPO-PEO or PEO-PBD-PEO, in water. Irradiation may be applied to the anticoagulant coatings and interior surfaces to form covalent bonds.