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Triblock copolymer PEO-PPO-PEO/calcium phosphate nanometer composite material and preparation method thereof

A technology of PEO-PPO-PEO and nano-composite materials, which is applied in the directions of non-active medical preparations, inorganic non-active ingredients, pharmaceutical formulations, etc., and can solve the problem that the triblock copolymer PEO-PPO-PEO is not much and so on. , to achieve the effect of broad use, convenient operation and small particle size

Inactive Publication Date: 2009-12-30
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many relevant reports on the application of the triblock copolymer PEO-PPO-PEO

Method used

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  • Triblock copolymer PEO-PPO-PEO/calcium phosphate nanometer composite material and preparation method thereof
  • Triblock copolymer PEO-PPO-PEO/calcium phosphate nanometer composite material and preparation method thereof
  • Triblock copolymer PEO-PPO-PEO/calcium phosphate nanometer composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: Preparation of triblock copolymer PEO-PPO-PEO / calcium phosphate nanocomposite material

[0043] Prepare P123 dispersion solution with a concentration of 2.5g / L and CaCl with a concentration of 0.5mol / L 2 aqueous solution and 0.5mol / L (NH 4 ) 3 PO 4 aqueous solution.

[0044] At room temperature, 0.100 g of P123 was added into 40 ml of water, stirred and dissolved at room temperature to obtain a uniformly dispersed solution. Add 1.5 ml of CaCl with a concentration of 0.5 mol / L to the solution 2 aqueous solution, and then add 0.9 ml of 0.5 mol / L (NH 4 ) 3 PO 4 aqueous solution to obtain a homogeneously dispersed suspension. After the reaction was complete, the product was separated by centrifugation, washed with water three times, and dried in air at 60° C. to obtain a P123-calcium phosphate nanocomposite material. Analysis shows that the morphology of the product is a porous structure, and the particle size is less than 100 nanometers. The prepara...

Embodiment 2

[0048] Example 2: Preparation of triblock copolymer PEO-PPO-PEO / calcium phosphate nanocomposite

[0049] At room temperature, 0.100 g of P123 was added into 40 ml of water, stirred and dissolved at room temperature to obtain a uniformly dispersed solution. Add 2.5 ml of Ca(NO 3 ) 2 aqueous solution, followed by the addition of 1.5 mL of Na at a concentration of 0.5 mol / L 3 PO 4 aqueous solution to obtain a homogeneously dispersed suspension. After the reaction is complete, the product is taken out, separated by centrifugation, washed with water three times, and dried in air at 60° C. to obtain a P123-calcium phosphate nanocomposite material. Analysis shows that the morphology of the product is a porous structure, and the particle size is less than 100 nanometers.

Embodiment 3

[0050] Example 3: Preparation of triblock copolymer PEO-PPO-PEO / calcium phosphate nanocomposite

[0051] At room temperature, 0.100 g of F127 was added into 20 ml of water, stirred and dissolved at room temperature to obtain a uniformly dispersed solution. Add 1.5 ml of 0.5 mol / L Ca(CH 3 COO) 2 aqueous solution, and then add 0.9 ml of 0.5 mol / L (NH 4 ) 2 HPO 4 aqueous solution to obtain a homogeneously dispersed suspension. After the reaction is complete, the product is taken out, separated by centrifugation, washed with water three times, and dried in air at 60° C. to obtain F127-calcium phosphate nanocomposite material. Analysis shows that the morphology of the product is a porous structure, and the particle size is less than 100 nanometers.

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Abstract

The invention relates to the nanometer biomaterial field, in particular to a triblock copolymer PEO-PPO-PEO / calcium phosphate nanometer composite material and a preparation method thereof. The microscopic particles of the nanometer composite material have calcium phosphate coated triblock copolymer PEO-PPO-PEO structure; wherein, the weight percent of triblock copolymer PEO-PPO-PEO is 5-40% of the total weight of the nanometer composite material and the weight percent of calcium phosphate is 60-95% thereof. The nanometer composite material of the invention can be used as drug carrier, has higher drug-loading rate and excellent slow release performance on water-insoluble drugs and has good application prospect in the Biomedical field; the preparation method is characterized of simple process, convenient operation, lower cost and environmentally friendly and can be operated at room temperature.

Description

technical field [0001] The invention belongs to the field of nano biological materials, in particular to a triblock copolymer PEO-PPO-PEO / calcium phosphate nanocomposite material and its preparation. Background technique [0002] A nanocomposite material is a composite material composed of two or more solid phases at least in one dimension at the nanoscale (1-100nm). These solid phases can be amorphous, semicrystalline, crystalline, or both, and can be inorganic, organic, or both. Nanocomposite materials can also refer to composite materials with one dimension of the dispersed phase less than 100nm. The composition of the dispersed phase can be inorganic compounds or organic compounds. Inorganic compounds usually refer to ceramics, metals, etc., and organic compounds usually refer to organic high molecular material. When the nanomaterial is the dispersed phase and the organic polymer is the continuous phase, it is a polymer-based nanocomposite. [0003] Nanocomposite mate...

Claims

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Application Information

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IPC IPC(8): C08L71/02C08K3/32C08L71/08C08F283/06A61K47/32A61K47/02
Inventor 朱英杰曹少文
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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