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Improving disinfection efficacy of lens care regimen for rigid gas permeable contact lenses

A breathable, lens technology, applied in chemical instruments and methods, detergent compositions, chemistry, etc.

Inactive Publication Date: 2009-04-01
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Still, it is more challenging to obtain a system that demonstrates effective cleaning and disinfection of contact lenses, especially RGP lenses, without requiring a wiping or rinsing regimen, or at least extrinsically or always requiring wiping and rinsing, for acceptable performance. Rinse, which is also desirable

Method used

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  • Improving disinfection efficacy of lens care regimen for rigid gas permeable contact lenses
  • Improving disinfection efficacy of lens care regimen for rigid gas permeable contact lenses
  • Improving disinfection efficacy of lens care regimen for rigid gas permeable contact lenses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-14

[0061] Examples 1-14 contain PHMB HCl and Composition of P123 biocidal individual test

[0062] Evaluation by Antimicrobial efficacy of solutions prepared with P123 and PHMB HCl for chemical disinfection of contact lenses using 10% organic contaminants. The solution components are listed in Tables 1 to 14 below.

[0063] Microbial challenge inoculum prepared with Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6538), Serratia marcescens (ATCC 13880), Candida albicans (ATCC 10231) and Fusarium solani (ATCC 36031) . Grow test organisms on appropriate agar and harvest the culture using sterile Dulbecco's Phosphate Buffered Saline plus 0.05% w / v Polysorbate 80 (DPBST) or a suitable diluent and transfer to a suitable container middle. The spore suspension was filtered through sterile glass wool to remove mycelial fragments. As appropriate, filter S. marcescens through a 1.2 micron filter to clarify the suspension. After harvesting, the suspension was cen...

Embodiment 15-32

[0097] Embodiment 15-32 adopts PHMB HCl: Alexidine 2HCl and Combination of P123 single test for biocidal

[0098] Experiments were carried out to investigate the use of Microbial killing effect of solutions prepared with P123 and a combination of PHMB HCl and alexidine 2HCl on 10%, 50% and 100% organic pollutants. The test solutions are identified in Tables 15-32 below. The antimicrobial efficacy of each chemical used to disinfect contact lenses was evaluated according to the methods outlined in Examples 1-14.

[0099] Microbial reductions using 10% organic pollutants are calculated at specific time points and recorded in the records listed below in Tables 15-28. Microbial reductions using 100% organic pollutants were calculated at specific time points and recorded in the records listed in Tables 29-30 below. Microbial reductions using 50% organic pollutants were calculated at specific time points and recorded in the records listed in Tables 31 to 32 below.

[010...

Embodiment 33

[0136] Example 33 - Preparation of Formulations

[0137] Table 33 lists the components of the base formulations used in the examples.

[0138] Table 33: Base formulations

[0139]

[0140] Table 34 lists the actual surfactant concentrations for Formulations I-IV. All formulations were prepared by mixing respective amounts of base formulation, surfactant and water. The formulation is then filtered.

[0141] Table 34: Composition of Formulations I-IV

[0142]

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PUM

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Abstract

A rigid gas permeable lens care composition. The composition includes a disinfecting amount of at least one biguanide antimicrobial agent and a straight chain polyether surfactant based upon PEO-PPO-PEO, PPO-PEO-PPO and combinations thereof. In one embodiment, the straight chain polyether surfactant has an HLB value of less than or equal to 15 and an average molecular weight value of between about 5000 and 7000. Preferably, no rubbing is required to disinfect the rigid gas permeable contact lenses is required. Methods of making and using the same are also described.

Description

technical field [0001] The present invention relates to a composition and method for disinfecting rigid gas permeable (RGP) contact lenses. In particular, the present invention relates to a composition and method for disinfecting RGP contact lenses that do not require a lens wiping step. Background technique [0002] Contact lenses in use today fall into three general categories: rigid lenses formed from materials prepared by the polymerization of acrylates, such as polymethylmethacrylate (PMMA); Rigid gas permeable (RGP) lenses formed from silicone methacrylate; and soft types such as gels and hydrogels. Because hard and rigid types of lenses have low vapor diffusion and absorb only small amounts of aqueous fluids, they have a lower tendency to bind active ingredients used in contact lens care solutions. In contrast, soft types of lenses have a higher tendency to bind active ingredients used in contact lens care solutions. Therefore, developing solutions for use as soft-...

Claims

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Application Information

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IPC IPC(8): A61L12/14C11D3/00
Inventor 夏尔宁J·C·萨拉莫内D·M·安蒙R·N·博拉兹亚尼
Owner BAUSCH & LOMB INC
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