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Application of composition of total saponins of astragalus and total paeony glycoside in systemic inflammatory response syndrome

A technology of total saponins of astragalus and total glucosides of paeony, which is applied in the direction of drug combinations, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the problems of slow progress in treatment, and achieve simple operation, cost reduction, and high drug quality. Stable and controllable effect

Inactive Publication Date: 2010-06-23
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, scientists from various countries have not found specific drugs to fight SIRS, and the progress of treatment is very slow

Method used

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  • Application of composition of total saponins of astragalus and total paeony glycoside in systemic inflammatory response syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The best examples are given below to further illustrate the present invention, but not to limit the present invention.

[0022] Method 1: In the GMP purification workshop, after mixing the above-mentioned total saponins of astragalus and total glucosides of paeony with suitable excipients, granulate according to the capsule preparation standard of the Chinese Pharmacopoeia, and divide into capsules with an automatic capsule filling machine to make capsules dose, each capsule contains 0.1-0.3 grams of medicine, and the patient takes 1-4 capsules each time, 2-3 times a day.

[0023] Method 2: In the GMP purification workshop, after mixing the above-mentioned total saponins of astragalus and total glucosides of paeony with suitable excipients, granulate according to the tablet standard of Chinese Pharmacopoeia, compress tablets with an automatic tablet machine, and make tablets. Each tablet contains 0.1-0.3 grams of medicine, and the patient takes 1-4 tablets each time, 2-...

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a composition of total saponins of astragalus and total paeony glycoside and an application thereof in a systemic inflammatory response syndrome. The composition is characterized in that the effective-part total saponins of astragalus and total paeony glycoside obtained from the traditional Chinese medicine of astragalus and red peony root are in compatibility according to certain proportion and added with pharmaceutical excipients to form and prepare preparations such as injection, powder injection, tablet and capsule having the function of treating the systemic inflammatory response syndrome. The pharmacological test result shows that the composition of the total saponins of astragalus and total paeony glycoside has synergistic therapeutical effect for the systemic inflammatory response syndrome.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing effective parts of traditional Chinese medicines Radix Astragali and Radix Paeoniae Rubra for preventing and treating systemic inflammatory response syndrome, in particular a pharmaceutical composition composed of total saponins of Radix Astragali and total glycosides of Radix Paeoniae Rubra. Background technique [0002] Despite the emergence of new clinical antibiotics, bacterial infectious diseases are still the main cause of death in ICU patients. In addition to the problem of drug resistance, the main problem is not that antibiotics cannot deal with bacteria or viruses, but that the use of antibiotics causes bacteria to be killed and release a large amount of endotoxin in the human body. A large amount of endotoxin will cause a strong inflammatory reaction process of systemic self-destruction, which will further lead to disseminated vascular coagulation, severe shock, or complication...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P29/00A61P31/00
Inventor 徐先祥戴岳高兴华
Owner CHINA PHARM UNIV