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Preparation method of copper ion chelation adsorption medium for treating Wilson's disease

A Wilson's disease, chelation adsorption technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, drug combinations, etc. and other problems, to achieve the effect of low preparation cost, low price and easy preparation

Inactive Publication Date: 2012-02-01
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because human serum albumin is derived from human plasma, it is not only expensive, but also has limited sources, which affects its wide application in the treatment of Wilson's disease

Method used

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  • Preparation method of copper ion chelation adsorption medium for treating Wilson's disease
  • Preparation method of copper ion chelation adsorption medium for treating Wilson's disease
  • Preparation method of copper ion chelation adsorption medium for treating Wilson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of Immobilized Triethylenetetramine Adsorption Media and Evaluation of Static Adsorption of Copper Ions

[0032] (1) Preparation of polytrimethylolpropane trimethacrylate-glycidyl methacrylate porous polymer microspheres [Poly(Trimethylolpropane trimethacrylate-co-glycidalmethacrylate), Poly(TRIM-co-GMA)]

[0033] The preparation of Poly(TRIM-co-GMA) porous polymer microspheres adopts the seed emulsion swelling polymerization method, and the preparation scheme includes the preparation of expanded polystyrene seed polymer microspheres and the absorption of trimethylolpropane by polystyrene seed microspheres. Poly(TRIM-co-GMA) was prepared in two stages by emulsion swelling polymerization of methacrylate, glycidyl methacrylate monomer and porogen.

[0034] (i) Preparation of Polystyrene Seed Polymer Microspheres

[0035] Dissolve 0.624g of polyvinylpyrrolidone and 290mg of azobisisobutylcyanide in 32mL of 95% (v / v) ethanol aqueous solution, add 8mL of styrene...

Embodiment 2

[0046] Preparation of Immobilized Tetraethylenepentamine Adsorption Media and Evaluation of Static Adsorption of Copper Ions

[0047] (1) The preparation method of polytrimethylolpropane trimethacrylate-glycidyl methacrylate porous polymer microspheres [Poly(TRIM-co-GMA)] is the same as that of Example 1.

[0048] (2) Preparation of immobilized tetraethylenepentamine adsorption medium

[0049] Add 3.8g Poly(TRIM-co-GMA) microspheres to 40mL tetraethylenepentamine, and react at 90°C for 24 hours. The prepared immobilized tetraethylenepentamine adsorption medium was washed three times successively with acetone, absolute ethanol and pure water, and then dried at 70°C for 24 hours for later use. The scanning electron microscope pictures of immobilized tetraethylenepentamine are as follows: figure 2 shown.

[0050] (3) Immobilized tetraethylenepentamine adsorption medium for static adsorption of copper ions in solution

[0051] The process of the adsorption experiment was the s...

Embodiment 3

[0053] Preparation of Immobilized Triethylenetetramine Adsorption Media and Evaluation of Dynamic Adsorption of Copper Ions

[0054] (1) The preparation method of polytrimethylolpropane trimethacrylate-glycidyl methacrylate porous polymer microspheres [Poly(TRIM-co-GMA)] is the same as that of Example 1.

[0055] (2) The preparation method of the immobilized triethylenetetramine adsorption medium is the same as that in Example 1.

[0056] (3) Performance evaluation of immobilized triethylenetetramine adsorption medium for dynamic adsorption of copper ions

[0057] Accurately weigh 75 mg of 3 parts of immobilized triethylenetetramine adsorption media, fill them into 2.5mL disposable medical polymer syringes, and seal both ends with polytetrafluoroethylene membranes to make immobilized triethylenetetramine At room temperature, 15mL of the 50mM copper ion solution prepared in Example 1 was passed through the adsorption column under the action of gravity, and the filtrate was rec...

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Abstract

The invention relates to a preparation method for copper ion chelate adsorbing medium used for curing Wilson's disease) in blood purification therapy, which obtains the copper ion chelate adsorbing medium by further bonding a copper ion sorbitol trine or tetraethylpentam through an ring-opening reaction between the epoxide groups on a polymer microsphere. The preparation method is simple to be operated, is easy to be realized and has a low preparation cost. The immobilized trine or tetraethylpentam adsorbing medium obtained through preparation has quick absorbing characteristic (reaching absorbing balance in 0.5 hour) and ideal absorbing effect (the absorbing amount can reach 80.4 plus or minus 2.8mg of copper ion / g of absorbing medium) to the copper ions. The immobilized trine or tetraethylpentam adsorbing medium obtained through the preparation method has excellent application prospect in curing Wilson's disease.

Description

technical field [0001] The invention relates to a preparation method of an adsorption medium used for blood purification, in particular to a preparation method of a copper ion chelation adsorption medium used for treating Wilson's disease. Background technique [0002] Wilson's disease is a disorder of copper ion metabolism with genetic characteristics, which leads to the accumulation of copper ion content in human organs, resulting in damage to various organs, especially damage to the liver and brain. The worldwide incidence of the disease is about 1 / 30000. Wilson's disease has a variety of clinical manifestations, the most common of which is chronic hepatitis or fulminant liver failure, and other symptoms include neurological or psychiatric symptoms, hemolytic anemia, endocrine disorders, and kidney stones. The diagnosis of Wilson's disease is usually based on the following criteria: (1) the presence or absence of Keyser-Fleischer rings in the eyes; (2) the amount of ceru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61P7/08A61P3/00A61K31/131A61K47/59
Inventor 邹汉法于志远吴仁安
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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