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Method and device for preparing nanoparticles of effective components of traditional Chinese medicine by supercritical technology

A technology of active ingredients and nanoparticles, which is applied in the field of direct preparation of active ingredient nanoparticles preparation technology and its device, can solve the problems of complex nanoparticle preparation technology, achieve the effects of simple operation, complex preparation technology and simple development process

Inactive Publication Date: 2010-07-21
NAT INST OF METROLOGY CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The problem to be solved by the present invention is the complex problem of nanoparticle preparation technology of the active ingredients of traditional Chinese medicinal materials

Method used

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  • Method and device for preparing nanoparticles of effective components of traditional Chinese medicine by supercritical technology
  • Method and device for preparing nanoparticles of effective components of traditional Chinese medicine by supercritical technology

Examples

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Embodiment 1

[0065] Supercritical fluid technology for directly preparing carnosic acid from rosemary

[0066] ①Open the cooling tank to reduce the cooling temperature to about -10℃;

[0067] ②Check and ensure that the inlet valve of the thermostat is closed;

[0068] ③ Turn on the main power of the thermostat and set the outlet valve temperature about 15-20 minutes before operation;

[0069] ④Turn on the compressor to increase the pressure and observe the pressure gauge to confirm that the pressure meets the requirements;

[0070] ⑤Open CO 2 Cylinder valve, increase the pressure to about 6MPa, open the thermostat inlet valve, and vent a little to confirm CO 2 The gas path is unobstructed, then close the inlet valve;

[0071] ⑥ Put the autoclave filled with experimental materials into the thermostat holder and connect the connecting pipe (note the thread direction and sealing), and clamp the thermocouple rod; when filling the rosemary material, put glass on both ends of the autoclave Cotton to preve...

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Abstract

The invention relates to a method and a device for preparing nanoparticles of effective components of traditional Chinese medicine by a supercritical technology. In the method of the invention, a supercritical fluid extraction technology and a supercritical fluid quick expansion fluid technology are coupled and carried out in the same process. The effective components of the traditional Chinese medicine are treated by supercritical fluid extraction, and then directly form nanoparticles by supercritical quick expansion. The method of the invention has high selectivity, is suitable for low-polar or non-polar effective components, couples the supercritical fluid extraction technology and the supercritical quick expansion technology, has the advantages of simple and quick operation, easy developing process, and the like, and solves the limit of the current preparation technology of nanoparticles of the effective components of the traditional Chinese medicinal materials.

Description

Technical field [0001] The invention relates to a method and equipment for extracting active ingredients of traditional Chinese medicines using chemical separation and nanotechnology, in particular to a preparation process and a device for directly preparing active ingredient nanoparticles from traditional Chinese medicinal materials using supercritical fluid technology. Background technique [0002] The technical terms involved in the present invention are as follows: [0003] Supercritical state: refers to the state where the fluid is above its critical temperature and critical pressure. Supercritical fluids have many excellent properties, such as low viscosity relative to liquids, large diffusion coefficients, and exceptional thermal conductivity in the near-critical region. The typical area of ​​supercritical fluid extraction, ie 0.95<T r <1.2, 1<P r <5, CO 2 It exhibits high compressibility in this area, and the density is sensitive to temperature or pressure chan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/16A61J3/00B01J2/06B01D11/02
Inventor 刘军全灿黄挺
Owner NAT INST OF METROLOGY CHINA