Method utilizing alkoxy or aryloxy rare earth catalyst to synthesize polypeptide

Abstract

The invention discloses a method utilizing an alkoxy or aryloxy rare earth catalyst to synthesize polypeptide. An N-carboxyl anhydride monomer and the rare earth catalyst are polymerized to obtain the polypeptide. The N-carboxyl anhydride monomer is glutamic acid-gamma-dimethrin- N-carboxyl anhydride and / or N-epsilon-benzoxy carbonyl-L-lysine-N-carboxyl anhydride. The rare earth catalyst can adopt alkoxy rare earth or aryloxy rare earth. The structures of the alkoxy rare earth and the aryloxy rare earth are respectively shown in formulas (1) and (2). In the formulas (1) and (2), Ln stands forrare-earth metal elements and is anyone of Sc, Y, La to Lu, R stands for alkyl, and R` and R`` stand for hydrogen atoms or the alkyl. The characteristics of the method in the invention are as follows: the alkoxy rare earth or the aryloxy rare earth is adopted as the catalyst for the first time to carry out ring-opening polymerization on the N-carboxyl anhydride monomer so as to generate the polypeptide; the catalyst not only is usually low in price and high in activity, but also is easily obtained; the polypeptide with HMW (high molecular weight) can be prepared, and the MWD (molecular weightdistribution) of the polypeptide is narrow (smaller than or equal to 1.4); moreover, copolymerization among different polypeptides can be realized.

Description

technical field The invention relates to two novel rare earth metal catalysts: an aryloxy rare earth catalyst and an alkoxy rare earth catalyst, and a synthesis method of a polypeptide. Background technique Many polymer materials, such as polylactone, polylactide, polycarbonate, polyanhydride, polyamino acid, polyphosphazene, etc., have been increasingly used in biomedical research. Studies have shown that the most commonly used polyester materials degrade after implantation into products with carboxyl groups, and these degradation products can cause inflammation, so they are not ideal biomedical materials. Polyamino acids, namely polypeptide materials, are made from natural amino acids. Its raw materials are rich in sources and are not limited to petroleum resources. After being degraded in the body, the amino acids necessary for the human body can be obtained without causing Inflammatory response, known as the best biocompatible material. At this stage, more and more rep...

AI Technical Summary

Problems solved by technology

So far, these two types of compounds have not been used to catalyze the polymerization of N-carboxy anhydrides.