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Water-soluble monodisperse iron-nickel magnetic nanoparticles and application thereof

A magnetic nanoparticle, monodisperse technology, applied in the direction of nuclear magnetic resonance / magnetic resonance imaging contrast agent, emulsion delivery, drug delivery, etc., to achieve the effect of good water solubility, low price and strong relaxation ability

Inactive Publication Date: 2011-11-09
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of further research and development, there are many areas to be improved for MRI contrast agents, such as paramagnetic efficiency (including T1 and T2), dosage, preparation cost, toxicity and stability, distribution in vivo, metabolism and pharmacological issues

Method used

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  • Water-soluble monodisperse iron-nickel magnetic nanoparticles and application thereof
  • Water-soluble monodisperse iron-nickel magnetic nanoparticles and application thereof
  • Water-soluble monodisperse iron-nickel magnetic nanoparticles and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh NiCl 2 .6H 2 O (2.377g, 10mmol) was dissolved in 10ml of water, then acetylacetone (4.1ml, 40mmol) was added to the reaction solution, under room temperature, magnetically stirred, after 15min, the stirring was stopped, and 3ml of triethylamine was added to the reaction solution. A large green precipitate will appear, filter.

[0036] Then prepare a mixed solution of ethanol and water (the volume ratio of ethanol and water is 8: 2), add the obtained green solid to the solution, stir at a temperature of 90°C until it is completely dissolved, then cool at room temperature, and find that Green flaky crystals, filtered, the green flaky crystals obtained are the desired product Ni(acac) 2 .

Embodiment 2

[0038] Weigh FeCl 3 (1.62g, 10mmol) was dissolved in 10ml of water, then added acetylacetone (6.15ml, 60mmol) in the reaction solution, under the condition of room temperature, magnetic stirring, stop stirring after 15min, add 3ml triethylamine, the reaction solution will A large amount of red precipitate appeared and was filtered.

[0039] Then prepare a mixed solution of ethanol and water (the volume ratio of ethanol to water is 7:3), add the obtained red solid to this solution, stir at a temperature of 80°C until it is completely dissolved, then cool at room temperature, and filter to obtain The red granular crystal is the desired product Fe(acac) 3 .

Embodiment 3

[0041] Take the prepared Fe(acac) of embodiment 1 and 2 3 (0.75mmol, 0.2647g) and Ni(acac) 2 (2.25mmol, 0.5775g), was added to a 100ml three-necked flask, and oil amine (20mL, 75.5%) was added to a 100ml three-necked flask.

[0042] Under the condition of magnetic stirring, first heated to 130°C with N 2 Drain the water and air in the reaction solution, maintain the nitrogen protection state, heat for 0.5h; then raise the temperature to 300°C and reflux for 1h; stop stirring, cool to room temperature, centrifuge, and use absolute ethanol and cyclohexane with a volume ratio of 1: The mixed solution of 1 (can be mixed in any volume ratio) was washed 3 to 5 times to obtain a black substance, which was dried in vacuum. This black substance is oil-soluble FeNi whose surface is oleylamine 3 magnetic nanoparticles.

[0043] Tested by JEOL JEM-2100 High Resolution Transmission Electron Microscope (HR-TEM), the obtained Transmission Electron Microscope (TEM) photos and High Resolut...

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Abstract

The invention discloses water-soluble monodisperse iron-nickel magnetic nanoparticles, which are prepared by a method comprising the following steps of: firstly, using oleyl amine as a solvent and a reducing agent to perform pyrolysis on iron acetylacetonate and nickel acetylacetonate so as to obtain oil-soluble iron-nickel magnetic nanoparticles; secondly, using a ligand exchange method to skillfully transform the oil-soluble iron-nickel magnetic nanoparticles into water-soluble nanoparticles; and thirdly, coupling the water-soluble nanoparticles with water-soluble biological macromolecules to obtain monodisperse magnetic nanoparticles with good biocompatibility. The preparation method has low requirements on equipment and has convenient operational processes, the needed raw materials have low prices, and byproducts are nuisance-less. Finally, magnetic resonance imaging experimental tests show that the water-soluble monodisperse iron-nickel magnetic nanoparticles can be used as a good magnetic resonance imaging contrast agent. The invention provides an economical and practical new method for the synthesis and the preparation of nano magnetic resonance imaging contrast agent materials, and provides reference values for human body clinical trials.

Description

technical field [0001] The invention relates to a nano-magnetic resonance contrast agent material and a preparation method thereof, in particular to the synthesis and functionalization research of ferromagnetic iron-nickel nanoparticles. Background technique [0002] Magnetic resonance imaging uses different tissues of the organism to produce different resonance signals under the influence of an external magnetic field. The strength of the signal depends on the water content in the tissue and the relaxation time of the protons in the water molecules. Since Lauterbur first applied magnetic resonance imaging (MRI) to human diagnosis in 1973, this technology has developed rapidly and been widely used in the fields of biology and medicine. This technology has been widely used in the angiography of the head, nervous system, abdomen and blood vessels of the human body. It is particularly effective in detecting tissue necrosis, local ischemia and various malignant lesions, and can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24A61K49/06A61K49/18
Inventor 杨仕平李雪健杨红周宏刘刚
Owner SHANGHAI NORMAL UNIVERSITY
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