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Technology for producing injection-grade terramycin

A production process, oxytetracycline technology, applied in the field of injection-grade oxytetracycline production process, can solve the problems of high impurities, low absorption, unqualified methanol solubility, etc., and achieve the effect of low impurity content, simple production process and qualified solubility

Active Publication Date: 2010-08-25
CHIFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing technology is to produce oxytetracycline by fermentation method. In the post-process of oxytetracycline production by fermentation method, the product quality is improved by optimizing the process conditions; but the obtained product has problems such as unqualified solubility in methanol, many impurities, and low absorption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: (1) Add 50kg of oral grade oxytetracycline to a mixed solvent of 2600L methanol and 400L purified water, then add 15L reagent hydrochloric acid to dissolve it at a temperature of 40°C; then add in turn to dissolve with a small amount of purified water 0.8kg of yellow blood salt and 0.7kg of zinc sulfate, stirred for 30 minutes, filtered through 8222 nylon filter cloth, and then filtered through 0.2um microporous membrane; (2) Cool the above filtrate to 18°C, add 10% ammonia water to adjust When the pH value is 4.5, crystallization occurs; the crystallization solution is separated by a centrifuge after standing for 30 minutes, and the filter cake is washed with purified water until the pH value of the outlet water is 7; the wet product is produced after continuing to be separated by a centrifuge for 2 hours; (3) wet product Dry in a vacuum dryer at a temperature of 80-90° C. and a vacuum of 0.08 MPa for 5 hours to obtain injection-grade oxytetracycline.

Embodiment 2

[0015] Example 2: (1) Add 42kg of oral grade oxytetracycline to a mixed solvent of 2500L methanol and 380L purified water, then add 16L reagent hydrochloric acid to dissolve it at a temperature of 45°C; then add in turn to dissolve with a small amount of purified water 0.7kg yellow blood salt and 0.6kg zinc sulfate, after stirring for 30 minutes, filter through 8222 nylon filter cloth, and then filter through 0.2um microporous membrane; (2) cool the above filtrate to 16 ° C, add 10% ammonia water to adjust When the pH value is 4.5, crystallization occurs; the crystallization solution is separated by a centrifuge after standing for 30 minutes, and the filter cake is washed with purified water until the pH value of the outlet water is 7; the wet product is produced after continuing to be separated by a centrifuge for 2 hours; (3) wet product Dry in a vacuum dryer at a temperature of 80-90° C. and a vacuum of 0.08 MPa for 5 hours to obtain injection-grade oxytetracycline.

Embodiment 3

[0016] Example 3: (1) Add 56kg of oral grade oxytetracycline to a mixed solvent of 2700L methanol and 420L purified water, then add 18L reagent hydrochloric acid to dissolve it at a temperature of 42°C; then add in turn and dissolve with a small amount of purified water 0.9kg yellow blood salt and 0.8kg zinc sulfate, after stirring for 30 minutes, filter through 8222 nylon filter cloth, and then filter through 0.2um microporous membrane; (2) cool the above filtrate to 15°C, add 10% ammonia water to adjust When the pH value is 4.5, crystallization occurs; the crystallization solution is separated by a centrifuge after standing for 30 minutes, and the filter cake is washed with purified water until the pH value of the outlet water is 7; the wet product is produced after continuing to be separated by a centrifuge for 2 hours; (3) wet product Dry in a vacuum dryer at a temperature of 80-90° C. and a vacuum of 0.08 MPa for 5 hours to obtain injection-grade oxytetracycline.

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PUM

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Abstract

The invention discloses technology for producing injection-grade terramycin, which comprises the following steps of: adding oral terramycin into a mixed solvent of methanol and purified water, and then adding a reagent hydrochloric acid for dissolution; adding yellow prussiate of potash and zinc sulfate in turn, stirring and filtering; adding ammonia water to regulate the pH value to between 4.5 and 5.0 for crystallization; separating crystalline liquid to obtain wet products by using a centrifugal machine; performing purified water washing and vacuum drying on the wet products to obtain the injection-grade terramycin. The technology for producing the injection-grade terramycin has the advantages of simple process and low cost; the solubility of the injection-grade terramycin in methanol is qualified, the impurity content is low and the absorbance is high.

Description

technical field [0001] The invention belongs to the technical field of medicine manufacturing, in particular to an injection-grade oxytetracycline production process. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic, and it is mainly used in animals. With the rapid development of animal husbandry, the administration method of Oxytetracycline is also changing, and the demand for injection-grade Oxytetracycline is increasing. [0003] The existing technology is to produce oxytetracycline by fermentation method. In the post-process of oxytetracycline production by fermentation method, the product quality is improved by optimizing the process conditions; but the obtained product has problems such as unqualified solubility in methanol, many impurities, and low absorption. Contents of the invention [0004] The purpose of the present invention is to overcome the shortcoming of prior art, provide a kind of injection-grade oxytetracycline production pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/26C07C231/24
Inventor 何瑞娟张红玉景文华
Owner CHIFENG PHARMA CO LTD
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