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Pharmaceutical-grade zinc chloride bulk drug and preparation method thereof

A zinc chloride, pharmaceutical-grade technology, applied in the field of medicine, to achieve the effect of qualified alkali metal and alkaline earth metal content

Pending Publication Date: 2021-09-17
合肥市未来药物开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the specifications of zinc chloride used in domestic trace element preparations are all analytical reagents, not pharmaceutical grade, and there is no production and sales of zinc chloride with pharmaceutical grade specifications

Method used

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  • Pharmaceutical-grade zinc chloride bulk drug and preparation method thereof
  • Pharmaceutical-grade zinc chloride bulk drug and preparation method thereof
  • Pharmaceutical-grade zinc chloride bulk drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Put 300.00g of purified water and 100.00g of zinc oxide into a 1L four-neck flask (kettle) equipped with a mechanical stirring device, turn on the mechanical stirring device, and mix the zinc oxide and water to obtain a suspension;

[0034] Then 261.24g mass fraction of 36% hydrochloric acid is added in the constant pressure dropping funnel, the molar ratio of zinc oxide and hydrochloric acid is controlled to be 1:2.1, slowly open the valve of the constant pressure dropping funnel, let the hydrochloric acid slowly Drop in the four-necked flask (still), because the reaction exothermic is obvious, therefore need to control the temperature in the four-necked flask (still) below 80 ℃, after the hydrochloric acid drops, record the temperature in the four-necked flask (still), Stir and react until the system is clear and transparent to obtain the first reaction solution;

[0035] Add 20g of zinc powder to the four-necked flask (still) containing the first reaction solution, t...

Embodiment 2

[0039] Put 300.00g of purified water and 100.00g of zinc oxide into a 1L four-neck flask (kettle) equipped with a mechanical stirring device, turn on the mechanical stirring device, and mix the zinc oxide and water to obtain a suspension;

[0040] Then 236.36g mass fraction of 36% hydrochloric acid is added to the constant pressure dropping funnel, the molar ratio of zinc oxide and hydrochloric acid is controlled to be 1:1.9, the valve of the constant pressure dropping funnel is slowly opened, and the hydrochloric acid is slowly Drop in the four-necked flask (still), because the reaction exothermic is obvious, therefore need to control the temperature in the four-necked flask (still) below 70 ℃, after the hydrochloric acid drops, record the temperature in the four-necked flask (still), Stir and react until the system is clear and transparent to obtain the first reaction solution;

[0041] Add 19g of zinc powder to the four-necked flask (still) filled with the first reaction so...

Embodiment 3

[0045] Put 300.00g of purified water and 100.00g of zinc oxide into a 1L four-neck flask (kettle) equipped with a mechanical stirring device, turn on the mechanical stirring device, and mix the zinc oxide and water to obtain a suspension;

[0046]Then 248.80g mass fraction of 36% hydrochloric acid is added to the constant pressure dropping funnel, the molar ratio of zinc oxide and hydrochloric acid is controlled to be 1:2.0, the valve of the constant pressure dropping funnel is slowly opened, and the hydrochloric acid is slowly Drop in the four-necked flask (still), because the reaction exothermic is obvious, therefore need to control the temperature in the four-necked flask (still) below 80 ℃, after the hydrochloric acid drops, record the temperature in the four-necked flask (still), Stir and react until the system is clear and transparent to obtain the first reaction solution;

[0047] Add 20g of zinc powder to the four-necked flask (still) containing the first reaction solu...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a pharmaceutical-grade zinc chloride bulk drug, the preparation method comprises the following steps: mixing zinc oxide with water to obtain a turbid liquid; dropwise adding hydrochloric acid into the turbid liquid, and stirring to react until the system is clear and transparent, so as to obtain a first reaction liquid; adding zinc powder into the first reaction liquid, and then performing heating reaction to obtain second reaction liquid; filtering the second reaction solution to obtain a first filtrate; and adjusting the pH value of the first filtrate, and then concentrating and drying to obtain the pharmaceutical-grade zinc chloride bulk drug. The preparation method disclosed by the invention is simple to operate and relatively low in cost, and the prepared zinc chloride bulk drug product has very high safety.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a zinc chloride raw material medicine and a preparation method thereof. Background technique [0002] Zinc is one of the essential trace elements for the human body and plays an extremely important role in the growth and development of the human body. Zinc exists in many enzyme systems, such as respiratory enzymes, lactate dehydrogenase, superoxide dismutase, DNA and RNA polymerase, etc., and is an essential substance for the synthesis of nucleic acids, proteins, carbohydrates and the utilization of vitamin A. Zinc deficiency will not only affect the immune function of the human body and the normal metabolism of sugar, amino acid and vitamin A, but also affect the synthesis, degradation and energy metabolism of related proteins; in addition, zinc deficiency will also affect children's intelligence, growth and development, affect reproductive function. Therefore, pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G9/04
CPCC01G9/04C01P2006/80
Inventor 赵立军彭松徐国义肖垒朱巍张春辉
Owner 合肥市未来药物开发有限公司
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