High-efficiency liquid-phase preparation device of axial pressurizing chromatographic column
A technology of axial pressurization and high-efficiency liquid phase, applied in the direction of solid adsorbent liquid separation, chemical instruments and methods, separation methods, etc., can solve the problems of reducing column operating pressure, increasing column operating pressure, and low column efficiency, achieving High column efficiency, good reproducibility, short time effect
Active Publication Date: 2012-03-21
LIAOCHENG WANHE IND MFR
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Problems solved by technology
Choosing cheap coarse packing can reduce the operating pressure of the column, and using a cheaper low-pressure pump can meet the operating requirements, but its column efficiency is also low
On the contrary, if you choose a smaller and uniform solid phase packing, you can get a higher column efficiency, but this usually requires an increase in the operating pressure of the column
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[0023] like Figure 1 to Figure 4 As shown, an axially pressurized chromatographic column device for HPLC preparative chromatography includes a main frame 1, an axially pressurized chromatographic column 2, a loading cylinder 3 and a pressurized hydraulic station, and also includes a chromatographic column Column oscillating mechanism, hydraulic accumulator; the axially pressurized chromatography column 2 is connected to the main frame 1 through the oscillating mechanism; the hydraulic accumulator is installed in the hydraulic circuit between the loading cylinder and the pressurized hydraulic station Together, they form a hydraulic control circuit. Since the loading cylinder and the pressurized hydraulic station are connected through a hydraulic circuit, the pressurized hydraulic station can be installed in any suitable position.
[0024] The structure of the main frame 1 is all welded by rectangular tube stainless steel, and a platform for standing people and a ladder for ge...
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The invention provides an axial pressurizing chromatographic column device for a high performance liquid preparation chromatography, relates to the technical field of chromatography liquid-phase preparation. The invention comprises a main frame, an axial pressurizing chromatographic column body, a loading oil cylinder and a pressurizing hydraulic station. The invention is characterized by also comprising a chromatographic column oscillating mechanism. The axial pressurizing chromatographic column body is connected to the main frame through the chromatographic column oscillating mechanism. A hydraulic energy accumulator is also arranged on a hydraulic loop between the loading oil cylinder and the pressurizing hydraulic station. The axial pressurizing chromatographic column body comprises a chromatographic column shell, an upper end cover and a piston body assembly, and the lower end of the chromatographic column is connected with the loading oil cylinder through a flange assembly. The invention greatly improves the yield and the purity of a product, prolongs the service life of the chromatographic column, and can automatically and repeatedly fill, thereby saving the production cost.
Description
technical field [0001] The invention relates to the technical field of chromatography liquid phase preparation, in particular to an axially pressurized chromatography column device for high performance liquid phase preparation chromatography. Background technique [0002] High-performance liquid chromatography is a separation method that utilizes the small difference in adsorption or distribution coefficients of substances in two phases to achieve the purpose of separation. When the substance moves relatively between the two phases, the measured substance is distributed in the two phases for many times, so that the original small distribution difference has an amplified effect, so as to achieve the purpose of separation, analysis and determination of some physical and chemical constants. [0003] The chromatographic column is the core device in the preparation process of high performance liquid chromatography. The main index to measure the column efficiency is the height of ...
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IPC IPC(8): B01D15/22
Inventor 周建民王其新
Owner LIAOCHENG WANHE IND MFR