Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Applications of andrographolide derivatives in preparing anti-HIV medicines

A technology of andrographolide and deoxyandrographolide, applied in antiviral agents, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of anti-HIV activity of andrographolide derivatives not seen

Inactive Publication Date: 2010-09-15
CHINA PHARM UNIV
View PDF5 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report about the anti-HIV activity of andrographolide derivatives in the existing literature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Applications of andrographolide derivatives in preparing anti-HIV medicines
  • Applications of andrographolide derivatives in preparing anti-HIV medicines
  • Applications of andrographolide derivatives in preparing anti-HIV medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Cytotoxicity test and cytopathic inhibition test of andrographolide and its derivatives

[0046] I. Materials and methods

[0047] 1. Determination of Drugs and Compounds

[0048] Test samples andrographolide and its derivatives 1-22#. Positive control compound zidovudine

[0049] (3'-Azido-3'-deoxythymidine, AZT) was purchased from Sigma. The sample to be tested was dissolved in DMSO, the concentration of the stock solution was 25mg / ml, and the storage condition was: 4°C; AZT was dissolved in RPMI-1640 complete medium, sterilized by 0.22μm filter membrane, and stored at -20°C after aliquoting.

[0050] 2. Reagents and solutions

[0051] (1) Reagent

[0052] HEPES(N-2(2-Hydroxyethyl)piperazine-N'-(2-ethanesufonic acid), MTT(3,(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide), DMF(N , N'-Dimethylformamine), penicillin (Penicillin), streptomycin sulfate (Streptomycin sulfate), glutamine (Glutamine) were all purchased from Sigma Company; 2-mercap...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to applications of andrographolide derivatives A1-4, B1-2, C1-2 and D1-13 in preparing anti-HIV medicines.

Description

technical field [0001] The invention relates to the medical use of andrographolide derivatives, specifically refers to the use of andrographolide derivatives in the preparation of anti-HIV drugs, and belongs to the field of medicinal chemistry. Background technique [0002] AIDS, also known as acquired immunodeficiency syndrome (AIDS), is an infectious disease caused by human immunodeficiency virus (human immunodeficiency virus, HIV) and characterized by severe damage to the systemic immune system. So far, no AIDS vaccine has come out, and anti-HIV drugs are still the main means of AIDS prevention and treatment. Highly active antiretroviral therapy (HAART) is currently widely used clinically for the treatment of AIDS, but this therapy is expensive, has high toxicity and side effects, cannot completely eliminate HIV in the human body, and easily causes the virus to mutate and drug resistance. Therefore, searching for novel drugs with new targets, anti-drug resistance, low p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4015A61K31/365A61P31/18
Inventor 黄文龙张惠斌王彬钱海李晶罗荣华郑永唐
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com