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Ovarian tumor serum marker

A technology for serum markers and ovarian tumors, applied in measuring devices, instruments, scientific instruments, etc., can solve the problem of low sensitivity, achieve the effect of expanding the screening range and avoiding simple repeated competition

Inactive Publication Date: 2010-09-15
THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV +5
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NMR technology has the characteristics of rapidity and unbiasedness, but its sensitivity is too low compared with other technologies; other methods, such as CE / LIF technology, have high detection sensitivity, but they are selective detection, so chromatography-mass spectrometry is currently the A commonly used detection method that can better balance sensitivity and unbiasedness

Method used

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  • Ovarian tumor serum marker
  • Ovarian tumor serum marker
  • Ovarian tumor serum marker

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Experimental program
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Effect test

Embodiment 1

[0040] 1. Collection of serum samples from patients with various types of ovarian tumors

[0041] 362 cases of normal control group, 281 cases of benign group, 51 cases of borderline group and 305 cases of malignant group were collected.

[0042] 2. Use the selected metabolomics method based on mass spectrometry-chromatography to complete the screening of differentially expressed molecules in samples.

[0043] A Metabolomic Analysis Model for Biomarker Profile Discovery of Ovarian Cancer Malignancy was Established. Including malignant ovarian tumor group and healthy control group, benign ovarian tumor and healthy control group, borderline ovarian tumor and healthy control group, healthy control group and benign and malignant ovarian tumor, healthy control group and benign, malignant and borderline ovarian tumor The metabolic profile model of the whole serum components; the characteristic biomarker profile was found by multivariate statistical analysis method, and the characte...

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Abstract

The invention belongs to the technical field of biology, and particularly relates to an ovarian tumor serum marker. The serum of a patient is subjected to multi-level analysis with high flux and large scale by adopting color spectrum and mass spectrum technology so as to screen serum differential expression molecules, and the serum of the ovarian tumor patient is subjected to metabonomics and polypeptide spectrum analysis of different levels to determine a small molecular metabolism spectrum so as to find a plurality of groups of characteristic biomarkers related with benignant, borderline and malignant ovarian tumor. The invention is possible to provide a simple method for screening the ovarian tumor of different stages in large scale, and also can provide valuable reference for differential diagnosis of related clinical patients.

Description

technical field [0001] The invention belongs to the field of biological technology, and in particular relates to a serum marker for ovarian tumors. Background technique [0002] Studies have revealed that ovarian cancer is one of the three major malignant tumors in gynecology, and its mortality rate ranks first among malignant tumors of the female reproductive system. At present, there are still many difficulties in clinical early diagnosis of ovarian cancer. General physical examination and imaging examinations are of limited use. By the time they can be discovered and diagnosed, they are often in the middle or late stage, lacking early warning value. Commonly used serum markers such as: cancer antigen 125 (CA125) can suggest malignant ovarian tumors, but they are still easily confused with changes caused by inflammation and benign tumors, thus easily causing misdiagnosis (70%-80% accuracy) . In order to meet the increasing sensitivity and specificity requirements of clin...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72
Inventor 徐丛剑路鑫许国旺曹锐张晓燕陈静房国良康玉何以丰程明军万小平吴晓华赵素敏
Owner THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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