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Components of compound formula of Chinese medicament active parts, preparation process thereof and anti-diabetic use thereof

A technology of effective parts and effective components, applied in the field of compound prescription composition, preparation process and anti-diabetic application of effective parts of traditional Chinese medicine

Inactive Publication Date: 2010-09-22
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prescription composition of the new compound of the active part, the pharmacological effects of improving insulin resistance and treating type 2 diabetes have not been reported

Method used

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  • Components of compound formula of Chinese medicament active parts, preparation process thereof and anti-diabetic use thereof
  • Components of compound formula of Chinese medicament active parts, preparation process thereof and anti-diabetic use thereof
  • Components of compound formula of Chinese medicament active parts, preparation process thereof and anti-diabetic use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1. Coptis Rhizoma Alkaloid Extract

[0040] 1.1 1.25kg Coptidis rhizome coarse powder, add 20L 70% ethanol each time to reflux for 1 hour, extract 2 times in total, combine the extracts, concentrate at 60°C to a relative density of 1.24 (60°C) concentrate, add appropriate amount of water to dilute the concentrate to 3.5L, add concentrated hydrochloric acid dropwise to the aqueous solution until no precipitation occurs (about 65ml of concentrated hydrochloric acid is required), shake well, and let it stand overnight; filter, and wash the solid powder with twice the amount (volume / weight, ml / g) of water twice , drained; the solid powder was dried under reduced pressure at 60° C. to obtain 98 g of Coptidis rhizome alkaloid extract with a yield of 7.84%.

[0041]1.2 Coptidis Coptidis powder 1.25kg, add 6.25L 80% ethanol each time to reflux for 1 hour, extract twice in total, combine the extracts, concentrate at 56°C to a relative density of 1.20 (56°C) concentrate, ...

Embodiment 2

[0044] Example 2. Astragalus saponin extract

[0045] 2.1 Astragalus powder 3.0kg, add 30L of 70% ethanol to reflux for 2 hours each time, extract 3 times in total, combine the extracts, concentrate at 60°C until there is no alcohol smell, add 5 times the amount (volume / volume) of water to dissolve, filter, The filtrate was passed through a prepared D4020 macroporous adsorption resin column (1.4kg), washed with water until it was colorless, and then eluted with 80% ethanol until the eluate was free of saponin. The eluate was combined and concentrated at 60°C Concentrate to a relative density of 1.3 (60° C.); dried under reduced pressure into powder to obtain 43.5 g of astragaloside extract with a yield of 1.45%.

[0046] 2.2 Astragalus coarse powder 3.0kg, add 15L of 80% ethanol to reflux for 2 hours each time, extract 3 times in total, combine the extracts, concentrate at 60°C until there is no alcohol smell, add 5 times the amount (volume / volume) of water to dissolve, filter...

Embodiment 3

[0049] Embodiment 3. Honeysuckle polyol extract

[0050] 3.1 Honeysuckle coarse powder 1.5kg, add 30L water to decoct for 0.5 hours each time, extract twice in total, combine the extracts, concentrate at 60°C to a relative density of 1.0 (60°C) concentrate, add an equal volume of 95% ethanol while stirring , placed overnight; filtered, the precipitate was washed with dilute alcohol, the washing liquid was combined with the filtrate, concentrated at 60°C to a relative density of 1.0 (60°C), and passed through a pre-served AB-8 macroporous adsorption resin column (1.8 kg), washed with water until the eluate was evaporated to dryness without residue, the eluate was combined, concentrated at 60°C to a concentrated solution with a relative density of 1.0 (60°C); then spray-dried into powder, and 372.3g of polyol was obtained; the yield was 24.82%.

[0051] 3.2 Honeysuckle coarse powder 1.5kg, add 30L water to decoct for 0.5 hours each time, extract twice in total, combine the extr...

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Abstract

The invention discloses Chinese medicament compound active parts, which comprises 5 to 10 weight parts of golden thread alkaloid extract, 2 to 10 weight parts of astragaloside II extract and 5 to 15 weight parts of honeysuckle flower polyalcohol extract. The invention also discloses the preparation methods of the golden thread alkaloid extract, the astragaloside II extract and honeysuckle flower polyalcohol extract, a medicinal composition containing the Chinese medicament compound active parts and the use of the Chinese medicament compound active parts in the preparation of medicaments for improving insulin resistance and resisting diabetes.

Description

technical field [0001] The invention relates to a Chinese medicine compound effective part composed of coptis alkaloid extract, astragalus saponin extract and honeysuckle polyol extract, and a preparation method of coptis alkaloid extract, astragaloside extract and honeysuckle polyol extract, comprising The pharmaceutical composition of the effective part of the compound Chinese medicine and the application of the effective part of the compound Chinese medicine in the preparation of drugs for improving insulin resistance and antidiabetes belong to the technical field of traditional Chinese medicine. Background technique [0002] In recent years, the research on anti-diabetic western medicine has made considerable progress, breaking the pattern of two major oral hypoglycemic drugs, sulfonylureas and biguanides. Sensitizers and non-sulfonylurea insulin secretagogues were launched, making great contributions to the treatment of diabetes. There are also some side effects and un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P5/48A61P3/10
Inventor 申竹芳谢明智冯孝章王爱国孙素娟陈跃腾刘泉苏亚伦王欣聂万达高松朱晓丹刘伟
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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